A Study on the Evaluation of the Cytotoxicity of Al2O3, Nb2O5, Ta2O5, TiO2 and ZrO2

A Study on the Evaluation of the Cytotox AlO

Makale detayları

A Study on the Evaluation of the Cytotoxicity of Al2O3, Nb2O5, Ta2O5, TiO2 and ZrO2

Yazarlar:

A Study on the Evaluation of the Cytotox AlO

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Engineering and Environmental Sciences 2004 Vol.28 Issue 1, pp.49-54

Belge Tipi:

Makale

Yayın Tarihi:

12/2003

Belge Dili:

İngilizce

Document ID (Org No.):

2000745107

Sıklık:

Üç Yıllık

eISSN:

1303-6157

pISSN:

1300-0160

Özet:

 

Nearly all metals used in implants are pure or alloys  composed of transition elements forming spontaneously passive layers  on the surface in electrolytes in a wide pH region.  The  biocompatibility of these metals used in implants is tested before  surgical implantation.  Determining the biocompatibility of these  metals is implemented firstly by the testing of their cytotoxicity.   The first step consists of evaluating the cell morphology and  proliferation.  In this study, glass slices were coated with Al2O3,  Nb2O5, Ta2O5, TiO2 and ZrO2 using the sol-gel technique.  Then  Vero fibroblast cells were inoculated with these slices and the  influence of metal oxides on cell proliferation and morphology was  observed.  Metal oxides did not affect the cell morphology.  However,  the cell counts varied compared to those of the uncoated glass slices  (control): cell numbers decreased 30% with Al2O3 and Nb2O5, by  45% with Ta2O5 and by 58% with ZrO2.  There was no change in cell  numbers with TiO2.  These results might give an idea about the  cytotoxicity of the metal oxides tested.  However, the application of  other cytotoxicity tests and the testing of the samples with several  other cell types seem to be necessary.

 

Nearly all metals used in implants are pure or alloys  composed of transition elements forming spontaneously passive layers  on the surface in electrolytes in a wide pH region.  The  biocompatibility of these metals used in implants is tested before  surgical implantation.  Determining the biocompatibility of these  metals is implemented firstly by the testing of their cytotoxicity.   The first step consists of evaluating the cell morphology and  proliferation.  In this study, glass slices were coated with Al2O3,  Nb2O5, Ta2O5, TiO2 and ZrO2 using the sol-gel technique.  Then  Vero fibroblast cells were inoculated with these slices and the  influence of metal oxides on cell proliferation and morphology was  observed.  Metal oxides did not affect the cell morphology.  However,  the cell counts varied compared to those of the uncoated glass slices  (control): cell numbers decreased 30% with Al2O3 and Nb2O5, by  45% with Ta2O5 and by 58% with ZrO2.  There was no change in cell  numbers with TiO2.  These results might give an idea about the  cytotoxicity of the metal oxides tested.  However, the application of  other cytotoxicity tests and the testing of the samples with several  other cell types seem to be necessary.

Makale detayları

A Study on the Evaluation of the Cytotoxicity of Al2O3, Nb2O5, Ta2O5, TiO2 and ZrO2

Yazarlar: A Study on the Evaluation of the Cytotox AlO

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Engineering and Environmental Sciences 2004 Vol.28 Issue 1, pp.49-54

Belge Tipi: Makale

Yayın Tarihi: 12/2003

Belge Dili: İngilizce

Document ID (Org No.): 2000745107

Sıklık: Üç Yıllık

eISSN: 1303-6157

pISSN: 1300-0160

Sayı

Yazarlar:

A Study on the Evaluation of the Cytotox AlO

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Engineering and Environmental Sciences 2004 Vol.28 Issue 1, pp.49-54

Belge Tipi:

Makale

Yayın Tarihi:

12/2003

Belge Dili:

İngilizce

Document ID (Org No.):

2000745107

Sıklık:

Üç Yıllık

eISSN:

1303-6157

pISSN:

1300-0160