IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Funda Ulusu

Makale detayları

IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Yazarlar:

Funda Ulusu

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Information Modelling | Management and Ontologies

Dergi:

Journal of Scientific Reports-A Issue 054, pp.338-352

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293058

pISSN:

2687-6167

Anahtar kelimeler:

Özet:

 The objective of this investigation was to assess the total phenolic and flavonoid content within acetone and water extracts derived from Erica manipuliflora, Ferula communis, and Stevia rebaudiana plants. Additionally, the in vitro antioxidant and cytotoxic effects of these extracts were evaluated using the human cervical cancer HeLa cell line as a model. Among the three plant species examined, the highest concentrations of total phenols and flavonoids were found in the acetone extract of E. manipuliflora, measuring 365.29 mg GAEg DW and 105.42 mg QEg DW, respectively. Acetone and water extracts of E. manipuliflora showed higher DPPH scavenging activities IC50: 37.57 and 33.27 µgmL, respectively compared to other plants. furthermore, E. manipuliflora acetone extract IC50: 97.35 µgmL exhibited the highest inhibition in the HeLa cell line treated with the extracts, thus being the most effective extract on this cell line. As a result of the analyzes, it has been shown that F. communis and S. rebaudiana and especially E. manipuliflora are important natural antioxidant sources with their strong radical scavenging effects, as well as the anticancer potential of these plants.

 The objective of this investigation was to assess the total phenolic and flavonoid content within acetone and water extracts derived from Erica manipuliflora, Ferula communis, and Stevia rebaudiana plants. Additionally, the in vitro antioxidant and cytotoxic effects of these extracts were evaluated using the human cervical cancer HeLa cell line as a model. Among the three plant species examined, the highest concentrations of total phenols and flavonoids were found in the acetone extract of E. manipuliflora, measuring 365.29 mg GAEg DW and 105.42 mg QEg DW, respectively. Acetone and water extracts of E. manipuliflora showed higher DPPH scavenging activities IC50: 37.57 and 33.27 µgmL, respectively compared to other plants. furthermore, E. manipuliflora acetone extract IC50: 97.35 µgmL exhibited the highest inhibition in the HeLa cell line treated with the extracts, thus being the most effective extract on this cell line. As a result of the analyzes, it has been shown that F. communis and S. rebaudiana and especially E. manipuliflora are important natural antioxidant sources with their strong radical scavenging effects, as well as the anticancer potential of these plants.

 The objective of this investigation was to assess the total phenolic and flavonoid content within acetone and water extracts derived from Erica manipuliflora, Ferula communis, and Stevia rebaudiana plants. Additionally, the in vitro antioxidant and cytotoxic effects of these extracts were evaluated using the human cervical cancer HeLa cell line as a model. Among the three plant species examined, the highest concentrations of total phenols and flavonoids were found in the acetone extract of E. manipuliflora, measuring 365.29 mg GAEg DW and 105.42 mg QEg DW, respectively. Acetone and water extracts of E. manipuliflora showed higher DPPH scavenging activities IC50: 37.57 and 33.27 µgmL, respectively compared to other plants. furthermore, E. manipuliflora acetone extract IC50: 97.35 µgmL exhibited the highest inhibition in the HeLa cell line treated with the extracts, thus being the most effective extract on this cell line. As a result of the analyzes, it has been shown that F. communis and S. rebaudiana and especially E. manipuliflora are important natural antioxidant sources with their strong radical scavenging effects, as well as the anticancer potential of these plants.

 The objective of this investigation was to assess the total phenolic and flavonoid content within acetone and water extracts derived from Erica manipuliflora, Ferula communis, and Stevia rebaudiana plants. Additionally, the in vitro antioxidant and cytotoxic effects of these extracts were evaluated using the human cervical cancer HeLa cell line as a model. Among the three plant species examined, the highest concentrations of total phenols and flavonoids were found in the acetone extract of E. manipuliflora, measuring 365.29 mg GAEg DW and 105.42 mg QEg DW, respectively. Acetone and water extracts of E. manipuliflora showed higher DPPH scavenging activities IC50: 37.57 and 33.27 µgmL, respectively compared to other plants. furthermore, E. manipuliflora acetone extract IC50: 97.35 µgmL exhibited the highest inhibition in the HeLa cell line treated with the extracts, thus being the most effective extract on this cell line. As a result of the analyzes, it has been shown that F. communis and S. rebaudiana and especially E. manipuliflora are important natural antioxidant sources with their strong radical scavenging effects, as well as the anticancer potential of these plants.

Makale detayları

IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Yazarlar:

Funda Ulusu

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Information Modelling | Management and Ontologies

Dergi:

Journal of Scientific Reports-A Issue 054, pp.338-352

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293058

pISSN:

2687-6167

Erica manipuliflora

Ferula communis

Stevia rebaudiana

Antioxidant

Cytotoxic Activities

Phenolic Content

Sayı

Makale detayları

IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Yazarlar: Funda Ulusu

Yayıncı: Kütahya Dumlupinar University

Ana Başlıklar: Information Modelling | Management and Ontologies

Dergi: Journal of Scientific Reports-A Issue 054, pp.338-352

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293058

pISSN: 2687-6167

Erica manipuliflora

Ferula communis

Stevia rebaudiana

Antioxidant

Cytotoxic Activities

Phenolic Content

Sayı

Yazarlar:

Funda Ulusu

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Information Modelling | Management and Ontologies

Dergi:

Journal of Scientific Reports-A Issue 054, pp.338-352

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293058

pISSN:

2687-6167