Effect of Non-surgical Periodontal Therapy on Interleukin 17 in Gingival Crevicular Fluid and Serum of Coronary Artery Disease Patients with Periodontitis

Selva Keşir; Ebru Olgun; Üçler Kısa; Ezel Berker

Makale detayları

Effect of Non-surgical Periodontal Therapy on Interleukin 17 in Gingival Crevicular Fluid and Serum of Coronary Artery Disease Patients with Periodontitis

Yazarlar:

Selva Keşir | Ebru Olgun | Üçler Kısa | Ezel Berker

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.264-271

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352317

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: The role of proinflammatory cytokines in chronic periodontitis P and coronary artery diseases CAD is currently under investigation. Interleukin 17 IL 17 may play a role in the bidirectional pathogenesis of both conditions. The aim of the study is to explore the effect of non-surgical periodontal therapy on the gingival crevicular fluid GCF and serum levels of IL 17 in stable CAD patients with P. Methods: Sixty-one individuals were enrolled in the study including 32 chronic periodontitis 16 periodontitis CAD-P, 16 coronary artery disease with periodontitis CADP and 29 periodontally healthy subjects 15 CAD-P- and 14 patients with coronary artery disease CADP-. GCF and serum samples were obtained and probing pocket depth PPD, clinical attachment level CAL, plaque index PI and gingival index GI were recorded at baseline and three months post-treatment. GCF and serum IL 17 levels were analyzed by enzyme-linked immunosorbent assay ELISA. Results: We observed significant improvements in the whole mouth and sample tooth periodontal parameters both with p  .001 and as well as a reduction in GCF volume p  .05 following periodontal treatment in periodontitis groups CAD-P and CADP. Serum IL 17 levels significantly decreased in CADP group following the periodontal therapy baseline: 24.39 13.04 pgml; 3rd month 19.16 15.07 pgml, p  .05 while no significant alterations were observed in GCF samples. Conclusion: IL 17 is linked to proinflammatory response in atherosclerosis. Its post-treatment decrease in CADP group suggests IL 17 might be a useful biomarker for CAD-periodontitis relationship.

 Objective: The role of proinflammatory cytokines in chronic periodontitis P and coronary artery diseases CAD is currently under investigation. Interleukin 17 IL 17 may play a role in the bidirectional pathogenesis of both conditions. The aim of the study is to explore the effect of non-surgical periodontal therapy on the gingival crevicular fluid GCF and serum levels of IL 17 in stable CAD patients with P. Methods: Sixty-one individuals were enrolled in the study including 32 chronic periodontitis 16 periodontitis CAD-P, 16 coronary artery disease with periodontitis CADP and 29 periodontally healthy subjects 15 CAD-P- and 14 patients with coronary artery disease CADP-. GCF and serum samples were obtained and probing pocket depth PPD, clinical attachment level CAL, plaque index PI and gingival index GI were recorded at baseline and three months post-treatment. GCF and serum IL 17 levels were analyzed by enzyme-linked immunosorbent assay ELISA. Results: We observed significant improvements in the whole mouth and sample tooth periodontal parameters both with p  .001 and as well as a reduction in GCF volume p  .05 following periodontal treatment in periodontitis groups CAD-P and CADP. Serum IL 17 levels significantly decreased in CADP group following the periodontal therapy baseline: 24.39 13.04 pgml; 3rd month 19.16 15.07 pgml, p  .05 while no significant alterations were observed in GCF samples. Conclusion: IL 17 is linked to proinflammatory response in atherosclerosis. Its post-treatment decrease in CADP group suggests IL 17 might be a useful biomarker for CAD-periodontitis relationship.

 Objective: The role of proinflammatory cytokines in chronic periodontitis P and coronary artery diseases CAD is currently under investigation. Interleukin 17 IL 17 may play a role in the bidirectional pathogenesis of both conditions. The aim of the study is to explore the effect of non-surgical periodontal therapy on the gingival crevicular fluid GCF and serum levels of IL 17 in stable CAD patients with P. Methods: Sixty-one individuals were enrolled in the study including 32 chronic periodontitis 16 periodontitis CAD-P, 16 coronary artery disease with periodontitis CADP and 29 periodontally healthy subjects 15 CAD-P- and 14 patients with coronary artery disease CADP-. GCF and serum samples were obtained and probing pocket depth PPD, clinical attachment level CAL, plaque index PI and gingival index GI were recorded at baseline and three months post-treatment. GCF and serum IL 17 levels were analyzed by enzyme-linked immunosorbent assay ELISA. Results: We observed significant improvements in the whole mouth and sample tooth periodontal parameters both with p  .001 and as well as a reduction in GCF volume p  .05 following periodontal treatment in periodontitis groups CAD-P and CADP. Serum IL 17 levels significantly decreased in CADP group following the periodontal therapy baseline: 24.39 13.04 pgml; 3rd month 19.16 15.07 pgml, p  .05 while no significant alterations were observed in GCF samples. Conclusion: IL 17 is linked to proinflammatory response in atherosclerosis. Its post-treatment decrease in CADP group suggests IL 17 might be a useful biomarker for CAD-periodontitis relationship.

 Objective: The role of proinflammatory cytokines in chronic periodontitis P and coronary artery diseases CAD is currently under investigation. Interleukin 17 IL 17 may play a role in the bidirectional pathogenesis of both conditions. The aim of the study is to explore the effect of non-surgical periodontal therapy on the gingival crevicular fluid GCF and serum levels of IL 17 in stable CAD patients with P. Methods: Sixty-one individuals were enrolled in the study including 32 chronic periodontitis 16 periodontitis CAD-P, 16 coronary artery disease with periodontitis CADP and 29 periodontally healthy subjects 15 CAD-P- and 14 patients with coronary artery disease CADP-. GCF and serum samples were obtained and probing pocket depth PPD, clinical attachment level CAL, plaque index PI and gingival index GI were recorded at baseline and three months post-treatment. GCF and serum IL 17 levels were analyzed by enzyme-linked immunosorbent assay ELISA. Results: We observed significant improvements in the whole mouth and sample tooth periodontal parameters both with p  .001 and as well as a reduction in GCF volume p  .05 following periodontal treatment in periodontitis groups CAD-P and CADP. Serum IL 17 levels significantly decreased in CADP group following the periodontal therapy baseline: 24.39 13.04 pgml; 3rd month 19.16 15.07 pgml, p  .05 while no significant alterations were observed in GCF samples. Conclusion: IL 17 is linked to proinflammatory response in atherosclerosis. Its post-treatment decrease in CADP group suggests IL 17 might be a useful biomarker for CAD-periodontitis relationship.

Makale detayları

Effect of Non-surgical Periodontal Therapy on Interleukin 17 in Gingival Crevicular Fluid and Serum of Coronary Artery Disease Patients with Periodontitis

Yazarlar:

Selva Keşir | Ebru Olgun | Üçler Kısa | Ezel Berker

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.264-271

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352317

pISSN:

2459-1459

Interleukin 17

Periodontal disease

Coronary artery disease

Inflammation

Sayı

Makale detayları

Effect of Non-surgical Periodontal Therapy on Interleukin 17 in Gingival Crevicular Fluid and Serum of Coronary Artery Disease Patients with Periodontitis

Yazarlar: Selva Keşir | Ebru Olgun | Üçler Kısa | Ezel Berker

Yayıncı: Marmara University

Ana Başlıklar: Periodontics

Dergi: Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.264-271

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001352317

pISSN: 2459-1459

Interleukin 17

Periodontal disease

Coronary artery disease

Inflammation

Sayı

Yazarlar:

Selva Keşir | Ebru Olgun | Üçler Kısa | Ezel Berker

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.264-271

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352317

pISSN:

2459-1459