Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Özlem ÖZMEN; Ezgi OGUS

doi:https://doi.org/10.24880/maeuvfd.481960

Makale detayları

Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Yazarlar:

Özlem ÖZMEN | Ezgi OGUS

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Veterinary Journal of Mehmet Akif Ersoy University 2018 Vol.3 Issue 2, pp.106-110

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000555806

Sıklık:

Üç Yıllık

eISSN:

2148-6239

DOI:

https://doi.org/10.24880/maeuvfd.481960

Özet:

 





Transmissible venereal
tumor (TVT) is a sexually transmitted, naturally occurring tumor of the canine
family and often occurs in tropical and subtropical countries. The matrix metalloproteinases
(MMPs) are endogenous proteases accountable for the degradation of
extracellular matrix (ECM) components, such as collagen and other proteins including
the basement membrane. MMPs play a vital role in the tumor metastasis and
angiogenesis. Both MMP-2 and -7 strongly associated with the invasion and
metastasis of different cancer types. This study aims to investigate the MMP-2
and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemical
methods. Immunohistochemically, we observed increased MMP-2 and -7 expressions in
tumor cells. In addition, a positive correlation was determined between the tumor
size and immunoexpressions of the markers indicating
that both MMP-2 and -7 participate in the
TVT pathogenesis.




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Makale detayları

Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Yazarlar: Özlem ÖZMEN | Ezgi OGUS

Yayıncı: Burdur Mehmet Akif Ersoy University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Veterinary Journal of Mehmet Akif Ersoy University 2018 Vol.3 Issue 2, pp.106-110

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000555806

Sıklık: Üç Yıllık

eISSN: 2148-6239

DOI: https://doi.org/10.24880/maeuvfd.481960

Sayı

Yazarlar:

Özlem ÖZMEN | Ezgi OGUS

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Veterinary Journal of Mehmet Akif Ersoy University 2018 Vol.3 Issue 2, pp.106-110

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000555806

Sıklık:

Üç Yıllık

eISSN:

2148-6239

DOI:

https://doi.org/10.24880/maeuvfd.481960