Correlation between increased urinary serotonin levels and coronary artery disease in cigarette smoking patients

Necat YILMAZ¹; Yakup MERMERDAŞ; Esin EREN; Ayşenur YEĞİN¹; Emine NAMIDURU

Makale detayları

Correlation between increased urinary serotonin levels and coronary artery disease in cigarette smoking patients

Yazarlar:

Necat YILMAZ¹ | Yakup MERMERDAŞ | Esin EREN | Ayşenur YEĞİN¹ | Emine NAMIDURU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 4, pp.531-536

Belge Tipi:

Makale

Yayın Tarihi:

3/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755000

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Platelets secrete serotonin (5-hydroxytryptamine), which has several effects on the vascular wall and promotes thrombogenesis, mitogenesis, and the proliferation of smooth muscle cells. We therefore measured excreted levels of 5-hydroxytryptamine (5-HT) concentrations in urine as a means of assessing vascular lesions in patients with coronary artery disease ( CAD).   Materials and methods: Subjects who underwent coronary angiography were classified into 2 groups according to their diagnosis. The CAD group consisted of 33 patients with coronary artery stenosis, whereas the healthy control group consisted of 30 subjects. An isocratic high-performance liquid chromatographic (HPLC) system with an electrochemical detector was used for the HPLC analysis of serotonin in urine.   Results: The mean urine 5-HT concentration was significantly (P < 0.01) higher in CAD patients than in the healthy control patients. Interestingly, the excretion of the urinary 5-HT levels in CAD patients were positively associated with cigarette smoking (r = 0.411, P < 0.01), serum hs-CRP levels (r = 0.198, P < 0.05), and age (r = 0.132, P < 0.05).  Conclusion: The increase in the amount of serotonin in urine in correlation with cigarette smoking, age, and hs-CRP may be important for future treatment strategies.

 

Platelets secrete serotonin (5-hydroxytryptamine), which has several effects on the vascular wall and promotes thrombogenesis, mitogenesis, and the proliferation of smooth muscle cells. We therefore measured excreted levels of 5-hydroxytryptamine (5-HT) concentrations in urine as a means of assessing vascular lesions in patients with coronary artery disease ( CAD).   Materials and methods: Subjects who underwent coronary angiography were classified into 2 groups according to their diagnosis. The CAD group consisted of 33 patients with coronary artery stenosis, whereas the healthy control group consisted of 30 subjects. An isocratic high-performance liquid chromatographic (HPLC) system with an electrochemical detector was used for the HPLC analysis of serotonin in urine.   Results: The mean urine 5-HT concentration was significantly (P < 0.01) higher in CAD patients than in the healthy control patients. Interestingly, the excretion of the urinary 5-HT levels in CAD patients were positively associated with cigarette smoking (r = 0.411, P < 0.01), serum hs-CRP levels (r = 0.198, P < 0.05), and age (r = 0.132, P < 0.05).  Conclusion: The increase in the amount of serotonin in urine in correlation with cigarette smoking, age, and hs-CRP may be important for future treatment strategies.

Makale detayları

Correlation between increased urinary serotonin levels and coronary artery disease in cigarette smoking patients

Yazarlar:

Necat YILMAZ¹ | Yakup MERMERDAŞ | Esin EREN | Ayşenur YEĞİN¹ | Emine NAMIDURU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 4, pp.531-536

Belge Tipi:

Makale

Yayın Tarihi:

3/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755000

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Smoking

serotonin

5-HT

urine

coronary

platelet

Sayı

Makale detayları

Correlation between increased urinary serotonin levels and coronary artery disease in cigarette smoking patients

Yazarlar: Necat YILMAZ¹ | Yakup MERMERDAŞ | Esin EREN | Ayşenur YEĞİN¹ | Emine NAMIDURU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 4, pp.531-536

Belge Tipi: Makale

Yayın Tarihi: 3/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000755000

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Smoking

serotonin

5-HT

urine

coronary

platelet

Sayı

Yazarlar:

Necat YILMAZ¹ | Yakup MERMERDAŞ | Esin EREN | Ayşenur YEĞİN¹ | Emine NAMIDURU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 4, pp.531-536

Belge Tipi:

Makale

Yayın Tarihi:

3/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755000

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144