Evaluation of Patients in a Region with Low Brucellosis Incidence

Melike Nur Özçelik; Esra Zerdali; İnci Yılmaz Nakir; Filiz Pehlivanoglu

Makale detayları

Evaluation of Patients in a Region with Low Brucellosis Incidence

Yazarlar:

Melike Nur Özçelik | Esra Zerdali | İnci Yılmaz Nakir | Filiz Pehlivanoglu

Yayıncı:

Harran University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.462-467

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352407

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: Brucellosis is the most common zoonotic disease in the worldwide. In the study aimed to evaluate 117 patients diagnosed with brucellosis in a province where the incidence of brucellosis is low. Materials and Methods: In the study, demographic characteristics, clinical findings, possible routes of transmission, treatment regimens, complication data and relapse rates of the patients who applied to infectious diseases outpatient clinic at a training and research hospital between 2014 and 2023 and were treated with a diagnosis of brucellosis were retrospectively examined. Results: The study included a total of 117 participation, of which 67 47.8 were female and 50 53.2 were men. The mean age of the patients was 48.3 18-77. The most common route of trans-mission was the consumption of unpasteurized milk and dairy products, particularly fresh cheese 61.5. The most common clinical symptoms were fatigue 57.2, myalgia 56.4 and fever 54.7. When the laboratory findings of the cases were evaluated, the most common findings were C-reactive protein increase 64.1, erythrocyte sedimentation rate increase 63.2 and lymphomo-nocytosis 38.6. The most common complications of brucellosis was hematological 64.1, osteo-articular 29.9 and hepatobiliary 19.6. Epididymoorchitis was detected in three patients 2.5, while endocarditis and meningitis were each identified in one patient 0.8 as rare complications. The most commonly used treatment was rifampicindoxycycline combination 72.6. Relapse was observed in 12 10.2 patients included in the study during the one-year follow-up after treatment. Conclusions: Brucellosis has significant effects on public health in endemic countries. It can present with very different clinical symptoms. Even in patients admitted to hospital in a region where the incidence of brucellosis is low, brucellosis should always be taken into consideration if the countryis endemic. The treatment approach should be individualized based on the complications that develop.

 Background: Brucellosis is the most common zoonotic disease in the worldwide. In the study aimed to evaluate 117 patients diagnosed with brucellosis in a province where the incidence of brucellosis is low. Materials and Methods: In the study, demographic characteristics, clinical findings, possible routes of transmission, treatment regimens, complication data and relapse rates of the patients who applied to infectious diseases outpatient clinic at a training and research hospital between 2014 and 2023 and were treated with a diagnosis of brucellosis were retrospectively examined. Results: The study included a total of 117 participation, of which 67 47.8 were female and 50 53.2 were men. The mean age of the patients was 48.3 18-77. The most common route of trans-mission was the consumption of unpasteurized milk and dairy products, particularly fresh cheese 61.5. The most common clinical symptoms were fatigue 57.2, myalgia 56.4 and fever 54.7. When the laboratory findings of the cases were evaluated, the most common findings were C-reactive protein increase 64.1, erythrocyte sedimentation rate increase 63.2 and lymphomo-nocytosis 38.6. The most common complications of brucellosis was hematological 64.1, osteo-articular 29.9 and hepatobiliary 19.6. Epididymoorchitis was detected in three patients 2.5, while endocarditis and meningitis were each identified in one patient 0.8 as rare complications. The most commonly used treatment was rifampicindoxycycline combination 72.6. Relapse was observed in 12 10.2 patients included in the study during the one-year follow-up after treatment. Conclusions: Brucellosis has significant effects on public health in endemic countries. It can present with very different clinical symptoms. Even in patients admitted to hospital in a region where the incidence of brucellosis is low, brucellosis should always be taken into consideration if the countryis endemic. The treatment approach should be individualized based on the complications that develop.

 Background: Brucellosis is the most common zoonotic disease in the worldwide. In the study aimed to evaluate 117 patients diagnosed with brucellosis in a province where the incidence of brucellosis is low. Materials and Methods: In the study, demographic characteristics, clinical findings, possible routes of transmission, treatment regimens, complication data and relapse rates of the patients who applied to infectious diseases outpatient clinic at a training and research hospital between 2014 and 2023 and were treated with a diagnosis of brucellosis were retrospectively examined. Results: The study included a total of 117 participation, of which 67 47.8 were female and 50 53.2 were men. The mean age of the patients was 48.3 18-77. The most common route of trans-mission was the consumption of unpasteurized milk and dairy products, particularly fresh cheese 61.5. The most common clinical symptoms were fatigue 57.2, myalgia 56.4 and fever 54.7. When the laboratory findings of the cases were evaluated, the most common findings were C-reactive protein increase 64.1, erythrocyte sedimentation rate increase 63.2 and lymphomo-nocytosis 38.6. The most common complications of brucellosis was hematological 64.1, osteo-articular 29.9 and hepatobiliary 19.6. Epididymoorchitis was detected in three patients 2.5, while endocarditis and meningitis were each identified in one patient 0.8 as rare complications. The most commonly used treatment was rifampicindoxycycline combination 72.6. Relapse was observed in 12 10.2 patients included in the study during the one-year follow-up after treatment. Conclusions: Brucellosis has significant effects on public health in endemic countries. It can present with very different clinical symptoms. Even in patients admitted to hospital in a region where the incidence of brucellosis is low, brucellosis should always be taken into consideration if the countryis endemic. The treatment approach should be individualized based on the complications that develop.

 Amaç: Bruselloz, dünyada en yaygın görülen zoonotik hastalıktır. Bu çalışmada, bruselloz insidansının düşük olduğu bir ilde bruselloz tanısı konulan 117 hastanın değerlendirilmesi amaçlanmıştır. Materyal ve metod: Çalışmada bir eğitim ve araştırma hastanesinin enfeksiyon hastalıkları polikliniğine 2014-2023 yılları arasında başvuran ve bruselloz tanısı alarak tedavi edilen hastaların demografik özellikleri, klinik bulguları, olası bulaş yolları, uygulanan tedavi rejimleri, gelişen komplikasyonlar ve relaps oranları retrospektif olarak incelenmiştir. Bulgular: Çalışmaya dahil edilen 117 hastanın 67si 57,2 kadın, 50si 42,8 erkek olup yaş ortala-ması 48,3 18-77 yıldı. En sık bulaş yolu, başta taze peynir tüketimi olmak üzere pastörize edilmemiş süt ve süt ürünleri tüketimiydi 61,5. Hastaların en sık başvuru semptomları halsizlik 57,2, miyalji 56,4 ve ateş 54,7 olarak tespit edildi. Laboratuvar bulguları değerlendirildiğinde en sık C-reaktif protein yüksekliği 64,1, eritrosit sedimantasyon hızı artışı 63,2 ve lenfomonositoz 38,6 sap-tandı. Brusellozun en sık görülen tutulum bölgeleri hematolojik 64,1, osteoartiküler 29,9 ve hepatobiliyer 19,6 sistemlerdi. Nadir komplikasyonlar arasında üç hastada epididimoorşit 2,5, bir hastada endokardit 0,8 ve bir hastada menenjit 0,8 görüldü. En yaygın uygulanan tedavi rejimi doksisiklin ve rifampisin kombinasyonu olup hastaların 72,6sında tercih edildi. Tedavi sonrası bir yıllık izlemde 12 hastada 10,2 relaps geliştiği gözlendi. Sonuç: Bruselloz, endemik bölgelerde halk sağlığı üzerinde önemli etkilere sahiptir ve geniş bir klinik spektrum ile ortaya çıkabilir. Bruselloz insidansının düşük olduğu bölgelerde dahi, hastanın yaşadığı ülke endemik bir bölgedeyse, ayırıcı tanıda bruselloz mutlaka göz önünde bulundurulmalıdır. Tedavi yaklaşımı ise gelişen komplikasyonlara göre bireyselleştirilerek planlanmalıdır.

Makale detayları

Evaluation of Patients in a Region with Low Brucellosis Incidence

Yazarlar:

Melike Nur Özçelik | Esra Zerdali | İnci Yılmaz Nakir | Filiz Pehlivanoglu

Yayıncı:

Harran University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.462-467

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352407

pISSN:

1304-9623

Brucellosis

Zoonosis

Focal involvement

ComplicationBruselloz

Zoonoz

Fokal tutulum

Komplikasyon

Sayı

Makale detayları

Yazarlar: Melike Nur Özçelik | Esra Zerdali | İnci Yılmaz Nakir | Filiz Pehlivanoglu

Yayıncı: Harran University

Ana Başlıklar: Bulaşıcı Hastalıklar

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.462-467

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001352407

pISSN: 1304-9623

Sayı

Yazarlar:

Melike Nur Özçelik | Esra Zerdali | İnci Yılmaz Nakir | Filiz Pehlivanoglu

Yayıncı:

Harran University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.462-467

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352407

pISSN:

1304-9623