Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

Cemal ORHAN; Nurhan ŞAHİN; Zeynep TUZCU; James R. KOMOROWSKI; Kazim ŞAHİN

Makale detayları

Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

Yazarlar:

Cemal ORHAN | Nurhan ŞAHİN | Zeynep TUZCU | James R. KOMOROWSKI | Kazim ŞAHİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 5, pp.1616-1625

Belge Tipi:

Makale

Yayın Tarihi:

9/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751167

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the serum and brain and lower Cr concentrations in serum, kidney, brain, and liver (P < 0.0001). CDB complex supplementation reversed all the effects, and the reversal effect was more pronounced with HFD for some parameters. Latency was less (P < 0.05) but probe was greater (P < 0.0001) for rats fed a regular diet. Increasing CDB complex levels in the diets resulted in a linear decrease in latency (P < 0.0002) but a linear increase in probe (P < 0.0002). Conclusion: Findings of the present work indicate that the CDB complex could be considered as an alternative treatment for preventing certain metabolic diseases and improving neurological functions, such as learning and memory.

Makale detayları

Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

Yazarlar: Cemal ORHAN | Nurhan ŞAHİN | Zeynep TUZCU | James R. KOMOROWSKI | Kazim ŞAHİN

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 5, pp.1616-1625

Belge Tipi: Makale

Yayın Tarihi: 9/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000751167

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Cemal ORHAN | Nurhan ŞAHİN | Zeynep TUZCU | James R. KOMOROWSKI | Kazim ŞAHİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 5, pp.1616-1625

Belge Tipi:

Makale

Yayın Tarihi:

9/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751167

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144