Analysis of JAM-A T>C (rs790056) and LFA-1 2120 G>C (rs2230433) gene variations in uterine leiomyoma

Özge KÖMÜRCÜ KARUSERCİ; Esra GÜZEL TANOĞLU; Halime Hanım PENÇE; Mete Gürol UĞUR

doi:https://doi.org/10.38053/acmj.843786

Makale detayları

Analysis of JAM-A T>C (rs790056) and LFA-1 2120 G>C (rs2230433) gene variations in uterine leiomyoma

Yazarlar:

Özge KÖMÜRCÜ KARUSERCİ | Esra GÜZEL TANOĞLU | Halime Hanım PENÇE | Mete Gürol UĞUR

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Anatolian Current Medical Journal 2021 Vol.3 Issue 1, pp.48-52

Belge Tipi:

Makale

Yayın Tarihi:

1/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000881876

Sıklık:

Üç Aylık

eISSN:

2718-0115

DOI:

https://doi.org/10.38053/acmj.843786

Özet:

 

Aim: We aimed to investigate the effect of junctional adhesion molecule-A (JAM-A) and
lymphocyte function-associated antigen 1 (LFA-1) gene variants on the development of
leiomyoma in Turkish women.
Materials and methods: Retrospectively, leiomyoma tissues from 102 patients who were operated due to leiomyoma between May 2018 and April 2019 and healthy myometrium tissues from 70 control group patients without leiomyoma who underwent hysterectomy due to other reasons were included in the study. JAM-A rs790056 (T>C) and LFA-1 rs2230433 (G>C) gene variants in all tissues were examined by the quantitative real-time polymerase chain reaction (qRT-PCR) technique. Statistical analyses were performed using SPSS 16 software package.
Results: The frequency of JAM-A rs790056 CC genotype and C allele was significantly higher in the leiomyoma group compared to the control group (p=0.01, p=0.02), as well as the LFA-1
rs2230433 GG genotype which was also higher compared to the control group (p=0.01).
Conclusion: JAM-A rs790056 was found to be more effective than LFA-1 rs2230433 in
determining the risk of uterine leiomyoma. According to the results, it has been determined that
variations in JAM-A and LFA-1 genes may cause predisposition to uterine leiomyoma in Turkish women.

Makale detayları

Analysis of JAM-A T>C (rs790056) and LFA-1 2120 G>C (rs2230433) gene variations in uterine leiomyoma

Yazarlar: Özge KÖMÜRCÜ KARUSERCİ | Esra GÜZEL TANOĞLU | Halime Hanım PENÇE | Mete Gürol UĞUR

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık teşvikleri

Dergi: Anatolian Current Medical Journal 2021 Vol.3 Issue 1, pp.48-52

Belge Tipi: Makale

Yayın Tarihi: 1/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000881876

Sıklık: Üç Aylık

eISSN: 2718-0115

DOI: https://doi.org/10.38053/acmj.843786

Sayı

Yazarlar:

Özge KÖMÜRCÜ KARUSERCİ | Esra GÜZEL TANOĞLU | Halime Hanım PENÇE | Mete Gürol UĞUR

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Anatolian Current Medical Journal 2021 Vol.3 Issue 1, pp.48-52

Belge Tipi:

Makale

Yayın Tarihi:

1/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000881876

Sıklık:

Üç Aylık

eISSN:

2718-0115

DOI:

https://doi.org/10.38053/acmj.843786