Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation

MUSTAFA CENGİZ; ADNAN AYHANCİ; HATİCE MEHTAP KUTLU; AHMET MUSMUL

Makale detayları

Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation

Yazarlar:

MUSTAFA CENGİZ | ADNAN AYHANCİ | HATİCE MEHTAP KUTLU | AHMET MUSMUL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 4, pp.807-814

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811615

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Özet:

 

Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this substance is poorly solved in water and tends to decompose in the intestine, its bioavailability decreasing before it can show real effect. With these limitations in mind, the present study aims to enhance the poor bioavailability of Sm by forming Sm-loaded solid lipid nanoparticles (Sm-SLNs) using the hot homogenization method. A characterization process was undertaken to determine possible impact of Sm on experimental kidney damage. Our biochemical and light microscopic results suggest that the group that received Sm-SLNs for the treatment of D-GalN/TNF-α-induced experimental kidney damage showed significantly more improvement than the group that received commercially available Sm. In conclusion, Sm-loaded SLN may be a useful system for the delivery of poorly water-soluble Sm and may also provide renoprotection.

Makale detayları

Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation

Yazarlar: MUSTAFA CENGİZ | ADNAN AYHANCİ | HATİCE MEHTAP KUTLU | AHMET MUSMUL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2016 Vol.40 Issue 4, pp.807-814

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000811615

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Sayı

Yazarlar:

MUSTAFA CENGİZ | ADNAN AYHANCİ | HATİCE MEHTAP KUTLU | AHMET MUSMUL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 4, pp.807-814

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811615

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152