The relationship between melatonin level, oxidative stress, fatigue and sleep disorders in multiple sclerosis patients

Yıldız Dağcı; Nuray Bilge; Mustafa Ceylan; Halil İbrahim Özkan

Makale detayları

The relationship between melatonin level, oxidative stress, fatigue and sleep disorders in multiple sclerosis patients

Yazarlar:

Yıldız Dağcı | Nuray Bilge | Mustafa Ceylan | Halil İbrahim Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hücresel Sinir Sistemi

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 2, pp.168-174

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312912

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aims: Our study aimed to investigate the relationship between oxidative stress and melatonin levels, sleep disturbances and fatigue in persons with MS pwMS. Methods: The study included 50 pwMS and 30 healthy controls. Levels of serum melatonin, glutathione peroxidase GPx, superoxide dismutase SOD, and malondialdehyde MDA were measured in both groups. Persons with MS pwMS were evaluated using the extended disability status scale EDDS while Pittsburgh sleep quality index PSQI, Epworth sleepiness scale, insomnia severity index, fatigue severity scale and Beck depression scale were used for both groups. Results: Persons with MS pwMS exhibited significantly higher sleep disturbances p0,001, PSQI score p0,001, sleep latency p0,014, insomnia severity p0,001, fatigue 0,001 and fatigue severity p0,001, and Beck depression scale scores p0,001 and SOD levels p0,001 compared to the control group, while exhibiting significantly lower levels of melatoninp0,004. In pwMS, patients who experienced difficulty sleeping had significantly lower melatonin levels compared to those who did not p0,049. In pwMS, the melatonin level showed a negative correlation with age r-0,341; p0,015 and EDSS r-0,386; p0,006. Persons with MS pwMS with fatigue had significantly higher EDSS p0,003, PUQI p0,001, Epworth sleepiness score p0,028 and insomnia scores p0,002, compared to those who didnt. Conclusion: Our results showed that the melatonin levels were lower, presence of fatigue, and fatigue severity were higher in pwMS with sleep disorders than in those without sleep disorders. The frequent occurrence of fatigueindirectly and sleep disturbances in pwMS can be attributed to low melatonin levels.

 Aims: Our study aimed to investigate the relationship between oxidative stress and melatonin levels, sleep disturbances and fatigue in persons with MS pwMS. Methods: The study included 50 pwMS and 30 healthy controls. Levels of serum melatonin, glutathione peroxidase GPx, superoxide dismutase SOD, and malondialdehyde MDA were measured in both groups. Persons with MS pwMS were evaluated using the extended disability status scale EDDS while Pittsburgh sleep quality index PSQI, Epworth sleepiness scale, insomnia severity index, fatigue severity scale and Beck depression scale were used for both groups. Results: Persons with MS pwMS exhibited significantly higher sleep disturbances p0,001, PSQI score p0,001, sleep latency p0,014, insomnia severity p0,001, fatigue 0,001 and fatigue severity p0,001, and Beck depression scale scores p0,001 and SOD levels p0,001 compared to the control group, while exhibiting significantly lower levels of melatoninp0,004. In pwMS, patients who experienced difficulty sleeping had significantly lower melatonin levels compared to those who did not p0,049. In pwMS, the melatonin level showed a negative correlation with age r-0,341; p0,015 and EDSS r-0,386; p0,006. Persons with MS pwMS with fatigue had significantly higher EDSS p0,003, PUQI p0,001, Epworth sleepiness score p0,028 and insomnia scores p0,002, compared to those who didnt. Conclusion: Our results showed that the melatonin levels were lower, presence of fatigue, and fatigue severity were higher in pwMS with sleep disorders than in those without sleep disorders. The frequent occurrence of fatigueindirectly and sleep disturbances in pwMS can be attributed to low melatonin levels.

 Aims: Our study aimed to investigate the relationship between oxidative stress and melatonin levels, sleep disturbances and fatigue in persons with MS pwMS. Methods: The study included 50 pwMS and 30 healthy controls. Levels of serum melatonin, glutathione peroxidase GPx, superoxide dismutase SOD, and malondialdehyde MDA were measured in both groups. Persons with MS pwMS were evaluated using the extended disability status scale EDDS while Pittsburgh sleep quality index PSQI, Epworth sleepiness scale, insomnia severity index, fatigue severity scale and Beck depression scale were used for both groups. Results: Persons with MS pwMS exhibited significantly higher sleep disturbances p0,001, PSQI score p0,001, sleep latency p0,014, insomnia severity p0,001, fatigue 0,001 and fatigue severity p0,001, and Beck depression scale scores p0,001 and SOD levels p0,001 compared to the control group, while exhibiting significantly lower levels of melatoninp0,004. In pwMS, patients who experienced difficulty sleeping had significantly lower melatonin levels compared to those who did not p0,049. In pwMS, the melatonin level showed a negative correlation with age r-0,341; p0,015 and EDSS r-0,386; p0,006. Persons with MS pwMS with fatigue had significantly higher EDSS p0,003, PUQI p0,001, Epworth sleepiness score p0,028 and insomnia scores p0,002, compared to those who didnt. Conclusion: Our results showed that the melatonin levels were lower, presence of fatigue, and fatigue severity were higher in pwMS with sleep disorders than in those without sleep disorders. The frequent occurrence of fatigueindirectly and sleep disturbances in pwMS can be attributed to low melatonin levels.

 Aims: Our study aimed to investigate the relationship between oxidative stress and melatonin levels, sleep disturbances and fatigue in persons with MS pwMS. Methods: The study included 50 pwMS and 30 healthy controls. Levels of serum melatonin, glutathione peroxidase GPx, superoxide dismutase SOD, and malondialdehyde MDA were measured in both groups. Persons with MS pwMS were evaluated using the extended disability status scale EDDS while Pittsburgh sleep quality index PSQI, Epworth sleepiness scale, insomnia severity index, fatigue severity scale and Beck depression scale were used for both groups. Results: Persons with MS pwMS exhibited significantly higher sleep disturbances p0,001, PSQI score p0,001, sleep latency p0,014, insomnia severity p0,001, fatigue 0,001 and fatigue severity p0,001, and Beck depression scale scores p0,001 and SOD levels p0,001 compared to the control group, while exhibiting significantly lower levels of melatoninp0,004. In pwMS, patients who experienced difficulty sleeping had significantly lower melatonin levels compared to those who did not p0,049. In pwMS, the melatonin level showed a negative correlation with age r-0,341; p0,015 and EDSS r-0,386; p0,006. Persons with MS pwMS with fatigue had significantly higher EDSS p0,003, PUQI p0,001, Epworth sleepiness score p0,028 and insomnia scores p0,002, compared to those who didnt. Conclusion: Our results showed that the melatonin levels were lower, presence of fatigue, and fatigue severity were higher in pwMS with sleep disorders than in those without sleep disorders. The frequent occurrence of fatigueindirectly and sleep disturbances in pwMS can be attributed to low melatonin levels.

Makale detayları

The relationship between melatonin level, oxidative stress, fatigue and sleep disorders in multiple sclerosis patients

Yazarlar:

Yıldız Dağcı | Nuray Bilge | Mustafa Ceylan | Halil İbrahim Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hücresel Sinir Sistemi

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 2, pp.168-174

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312912

pISSN:

2718-0115

Multiple sclerosis

melatonin

sleep disturbances

oxidative stress

fatigue

Sayı

Makale detayları

The relationship between melatonin level, oxidative stress, fatigue and sleep disorders in multiple sclerosis patients

Yazarlar: Yıldız Dağcı | Nuray Bilge | Mustafa Ceylan | Halil İbrahim Özkan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Hücresel Sinir Sistemi

Dergi: Anatolian Current Medical Journal Vol.6 Issue 2, pp.168-174

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312912

pISSN: 2718-0115

Multiple sclerosis

melatonin

sleep disturbances

oxidative stress

fatigue

Sayı

Yazarlar:

Yıldız Dağcı | Nuray Bilge | Mustafa Ceylan | Halil İbrahim Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hücresel Sinir Sistemi

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 2, pp.168-174

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312912

pISSN:

2718-0115