Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer

Awat Hamad Awla Ibraım; Dursun Özer; Fikret Karataş; Sinan Saydam

Makale detayları

Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer

Yazarlar:

Awat Hamad Awla Ibraım | Dursun Özer | Fikret Karataş | Sinan Saydam

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 2, pp.464-480

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287176

pISSN:

2147-835X

Anahtar kelimeler:

Özet:

 Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals control group were used. The amounts of vitamins A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12, glutathione GSH, GSSG stress biomarkers 4-HNE, MDA were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index BMI p0.05. In the breast cancer group, fat-soluble vitamins, A, E and β-carotene decreasing highly significant p0.001, decreasing water-soluble vitamins was found to be significant p0.05. No statistically significant difference was observed between the groups that received and did not receive treatment except vitamin B2 p 0.05 with in the cancer patients. Likewise, no significant difference was observed between the serum vitamin levels of breast cancer patients who breastfeed and not breastfeed, except for vitamins B2 and B3 p0.05. A high level of significant difference was observed between GSH, GSSG, MDA and 4-HNE in the breast cancer patient and control groups p0.001. There was no significant difference found in GSSG, MDA and HNE values according to the treatment status of breast cancer patients, on the other hand, a significant difference was observed in GSH and GSHGSSG values p0.05. While there was no significant difference in GSH, GSSG, MDA and 4-HNE values according to the breastfeeding status of patients, a significant difference was observed in GSHGSSG values p0.05.

 Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals control group were used. The amounts of vitamins A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12, glutathione GSH, GSSG stress biomarkers 4-HNE, MDA were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index BMI p0.05. In the breast cancer group, fat-soluble vitamins, A, E and β-carotene decreasing highly significant p0.001, decreasing water-soluble vitamins was found to be significant p0.05. No statistically significant difference was observed between the groups that received and did not receive treatment except vitamin B2 p 0.05 with in the cancer patients. Likewise, no significant difference was observed between the serum vitamin levels of breast cancer patients who breastfeed and not breastfeed, except for vitamins B2 and B3 p0.05. A high level of significant difference was observed between GSH, GSSG, MDA and 4-HNE in the breast cancer patient and control groups p0.001. There was no significant difference found in GSSG, MDA and HNE values according to the treatment status of breast cancer patients, on the other hand, a significant difference was observed in GSH and GSHGSSG values p0.05. While there was no significant difference in GSH, GSSG, MDA and 4-HNE values according to the breastfeeding status of patients, a significant difference was observed in GSHGSSG values p0.05.

 Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals control group were used. The amounts of vitamins A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12, glutathione GSH, GSSG stress biomarkers 4-HNE, MDA were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index BMI p0.05. In the breast cancer group, fat-soluble vitamins, A, E and β-carotene decreasing highly significant p0.001, decreasing water-soluble vitamins was found to be significant p0.05. No statistically significant difference was observed between the groups that received and did not receive treatment except vitamin B2 p 0.05 with in the cancer patients. Likewise, no significant difference was observed between the serum vitamin levels of breast cancer patients who breastfeed and not breastfeed, except for vitamins B2 and B3 p0.05. A high level of significant difference was observed between GSH, GSSG, MDA and 4-HNE in the breast cancer patient and control groups p0.001. There was no significant difference found in GSSG, MDA and HNE values according to the treatment status of breast cancer patients, on the other hand, a significant difference was observed in GSH and GSHGSSG values p0.05. While there was no significant difference in GSH, GSSG, MDA and 4-HNE values according to the breastfeeding status of patients, a significant difference was observed in GSHGSSG values p0.05.

 Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals control group were used. The amounts of vitamins A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12, glutathione GSH, GSSG stress biomarkers 4-HNE, MDA were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index BMI p0.05. In the breast cancer group, fat-soluble vitamins, A, E and β-carotene decreasing highly significant p0.001, decreasing water-soluble vitamins was found to be significant p0.05. No statistically significant difference was observed between the groups that received and did not receive treatment except vitamin B2 p 0.05 with in the cancer patients. Likewise, no significant difference was observed between the serum vitamin levels of breast cancer patients who breastfeed and not breastfeed, except for vitamins B2 and B3 p0.05. A high level of significant difference was observed between GSH, GSSG, MDA and 4-HNE in the breast cancer patient and control groups p0.001. There was no significant difference found in GSSG, MDA and HNE values according to the treatment status of breast cancer patients, on the other hand, a significant difference was observed in GSH and GSHGSSG values p0.05. While there was no significant difference in GSH, GSSG, MDA and 4-HNE values according to the breastfeeding status of patients, a significant difference was observed in GSHGSSG values p0.05.

Makale detayları

Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer

Yazarlar:

Awat Hamad Awla Ibraım | Dursun Özer | Fikret Karataş | Sinan Saydam

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 2, pp.464-480

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287176

pISSN:

2147-835X

Breast Cancer

Vitamins

Reduced glutation

oxidised glutation

4-hydroxy neoneal

malondealdehyde.

Sayı

Makale detayları

Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer

Yazarlar: Awat Hamad Awla Ibraım | Dursun Özer | Fikret Karataş | Sinan Saydam

Yayıncı: Sakarya University

Ana Başlıklar: Structural Biology

Dergi: Sakarya University Journal of Science Vol.27 Issue 2, pp.464-480

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001287176

pISSN: 2147-835X

Breast Cancer

Vitamins

Reduced glutation

oxidised glutation

4-hydroxy neoneal

malondealdehyde.

Sayı

Yazarlar:

Awat Hamad Awla Ibraım | Dursun Özer | Fikret Karataş | Sinan Saydam

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 2, pp.464-480

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287176

pISSN:

2147-835X