DETERMINATION OF THE GENETIC PROFILE OF MCT1 (SLC16A1) GENE A/T POLYMORPHISM AND GDF5 GENE T/C POLYMORPHISM RELATED TO CONNECTIVE TISSUE AND MUSCLE INJURY RISK IN YOUNG ATHLETES

Merve Bektaş; Recep Sürhat Müniroğlu

Makale detayları

DETERMINATION OF THE GENETIC PROFILE OF MCT1 (SLC16A1) GENE A/T POLYMORPHISM AND GDF5 GENE T/C POLYMORPHISM RELATED TO CONNECTIVE TISSUE AND MUSCLE INJURY RISK IN YOUNG ATHLETES

Yazarlar:

Merve Bektaş | Recep Sürhat Müniroğlu

Yayıncı:

Ankara University

Ana Başlıklar:

Fiziksel Aktivite ve Sağlık

Dergi:

SPORMETRE Beden Eğitimi ve Spor Bilimleri Dergisi Vol.22 Issue 2, pp.16-24

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319958

pISSN:

1304-284X

Anahtar kelimeler:

Özet:

 In this study, MCT1 SLC16A1 gene AT polymorphism related to muscle injury and GDF5 TC polymorphism related to connective tissue damage in young athletes were studied and it was investigated whether there was a difference in allele distribution in the athlete group related to connective tissue and muscle injury compared to the control group. Whether the allele distributions of the experimental and control groups were in balance was tested using the Hardy-Weinberg equation. Differences between groups were analyzed with Chi square Test. The confidence interval was determined as 95 p0.05. As a result of the research, no significant difference was found between the control group and athletes in terms of SLC16A1 gene AT polymorphism rs1049434. A significant difference was found between the athletes and the control group in terms of GDF5 gene TC polymorphism rs143383. CC and TC genotypes in athletes were more common than TT genotypes in individuals in the control group. This situation is in favor of athletes. As a result of the genotypes determined by studying the SLC16A1 and GDF5 gene polymorphisms in elite athlete groups within the scope of the research, coaches and club sports physicians can be informed and strategies can be developed to plan training to prevent injuries and to intervene in case of possible injury.

 In this study, MCT1 SLC16A1 gene AT polymorphism related to muscle injury and GDF5 TC polymorphism related to connective tissue damage in young athletes were studied and it was investigated whether there was a difference in allele distribution in the athlete group related to connective tissue and muscle injury compared to the control group. Whether the allele distributions of the experimental and control groups were in balance was tested using the Hardy-Weinberg equation. Differences between groups were analyzed with Chi square Test. The confidence interval was determined as 95 p0.05. As a result of the research, no significant difference was found between the control group and athletes in terms of SLC16A1 gene AT polymorphism rs1049434. A significant difference was found between the athletes and the control group in terms of GDF5 gene TC polymorphism rs143383. CC and TC genotypes in athletes were more common than TT genotypes in individuals in the control group. This situation is in favor of athletes. As a result of the genotypes determined by studying the SLC16A1 and GDF5 gene polymorphisms in elite athlete groups within the scope of the research, coaches and club sports physicians can be informed and strategies can be developed to plan training to prevent injuries and to intervene in case of possible injury.

 In this study, MCT1 SLC16A1 gene AT polymorphism related to muscle injury and GDF5 TC polymorphism related to connective tissue damage in young athletes were studied and it was investigated whether there was a difference in allele distribution in the athlete group related to connective tissue and muscle injury compared to the control group. Whether the allele distributions of the experimental and control groups were in balance was tested using the Hardy-Weinberg equation. Differences between groups were analyzed with Chi square Test. The confidence interval was determined as 95 p0.05. As a result of the research, no significant difference was found between the control group and athletes in terms of SLC16A1 gene AT polymorphism rs1049434. A significant difference was found between the athletes and the control group in terms of GDF5 gene TC polymorphism rs143383. CC and TC genotypes in athletes were more common than TT genotypes in individuals in the control group. This situation is in favor of athletes. As a result of the genotypes determined by studying the SLC16A1 and GDF5 gene polymorphisms in elite athlete groups within the scope of the research, coaches and club sports physicians can be informed and strategies can be developed to plan training to prevent injuries and to intervene in case of possible injury.

 Bu araştırmada, genç atletlerde kas yaralanması ile ilgili MCT1 SLC16A1 geni AT polimorfizmi ve bağ doku hasarı ile ilgili GDF5 TC polimorfizmi çalışılarak bağ doku ve kas yaralanması ile ilgili sporcu grubunda kontrol grubuna göre alel dağılımında bir farklılık bulunup bulunmadığı araştırılmıştır. Deney ve kontrol grubuna ait alel dağılımlarının dengede olup olmadığı Hardy-Weinberg eşitliği kullanılarak test edilmiştir. Gruplar arasındaki farklılık Chi square Testi ile analiz edilmiştir. Güven aralığı 95 olarak belirlenmiştir p0,05. Araştırmanın sonucunda SLC16A1 geni AT polimorfizmi rs1049434 açısından kontrol grubu ve sporcular arasında anlamlı bir fark bulunmamıştır. GDF5 geni TC polimorfizmi rs143383 açısından sporcular ile kontrol grubu arasında anlamlı bir fark bulunmuştur. Sporculardaki CC ve TC genotipi kontrol grubunda bulunan bireylerdeki TT genotipinden daha sık görülmüştür. Bu durum sporcuların lehinedir. Araştırma kapsamında çalışılan SLC16A1 ve GDF5 gen polimorfizmleri elit sporcu gruplarında çalışılarak belirlenen genotipler sonucunda antrenörler ve kulüp spor hekimleri bilgilendirilip yaralanmanın engellenmesine yönelik antrenmanlar planlanılması ve olası yaralanma durumunda müdahale için stratejiler geliştirilebilir.

Makale detayları

DETERMINATION OF THE GENETIC PROFILE OF MCT1 (SLC16A1) GENE A/T POLYMORPHISM AND GDF5 GENE T/C POLYMORPHISM RELATED TO CONNECTIVE TISSUE AND MUSCLE INJURY RISK IN YOUNG ATHLETES

Yazarlar:

Merve Bektaş | Recep Sürhat Müniroğlu

Yayıncı:

Ankara University

Ana Başlıklar:

Fiziksel Aktivite ve Sağlık

Dergi:

SPORMETRE Beden Eğitimi ve Spor Bilimleri Dergisi Vol.22 Issue 2, pp.16-24

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319958

pISSN:

1304-284X

Gene

Polymorphism

Injury

SLC16A1 (MCT1)

GDF5Gen

Polimorfizm

Yaralanma

SLC16A1 (MCT1)

GDF5

Sayı

Makale detayları

Yazarlar: Merve Bektaş | Recep Sürhat Müniroğlu

Yayıncı: Ankara University

Ana Başlıklar: Fiziksel Aktivite ve Sağlık

Dergi: SPORMETRE Beden Eğitimi ve Spor Bilimleri Dergisi Vol.22 Issue 2, pp.16-24

Belge Tipi: Makale

Yayın Tarihi: 7/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001319958

pISSN: 1304-284X

Sayı

Yazarlar:

Merve Bektaş | Recep Sürhat Müniroğlu

Yayıncı:

Ankara University

Ana Başlıklar:

Fiziksel Aktivite ve Sağlık

Dergi:

SPORMETRE Beden Eğitimi ve Spor Bilimleri Dergisi Vol.22 Issue 2, pp.16-24

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319958

pISSN:

1304-284X