Preparation and Characterization of Montmorillonite/Polycaprolactone Composite Scaffold Containing Strontium for Bone Tissue Engineering Studies

Aysel KOC DEMİR

doi:https://doi.org/10.18596/jotcsa.287302

Makale detayları

Preparation and Characterization of Montmorillonite/Polycaprolactone Composite Scaffold Containing Strontium for Bone Tissue Engineering Studies

Yazarlar:

Aysel KOC DEMİR

Yayıncı:

Turkish Chemical Society

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2016 Vol.3 Issue 3, pp.669-682

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000503896

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.287302

Özet:

 


Montmorillonite (MMT) has attracted much attention due to its intrinsic ability to incorporate cations. In this study, we developed scaffold combining strontium-modified MMT and polycaprolactone (SrMMT-PCL) to further utilise the osteoconductive properties of strontium. For this purpose, MMT was modified with strontium, and then blended with polycaprolactone (PCL) in specific ratios by using particulate leaching technique to obtain bone tissue-like biocomposite scaffold. The macrostructure and morphology were characterized by X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The release of Sr2+ from scaffolds into cell culture medium was determined by inductive coupled plasma optical emission spectrometer (ICP-OES). The pore size distrubition of scaffolds was determined by mercury intrusion porosimetry. The mechanical properties were also evaluated. The results of FTIR and XRD confirmed intercalation of PCL into MMT layers. TGA studies concluded that the MMT in PCL promoted the thermal degradation of the matrix. ICP results showed that Sr2+ was released from composite scaffolds. The majority of pore volume seems to be occupied by pores around 250-350 mm. SEM observations demonstrated the macroporous structure of the MMT-PCL sponges obtained by using the particulate leaching method. As a result, gained data suggests that obtained tissue-engineered scaffold has the potential to serve as a suitable templete for bone tissue engineering applications.

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Makale detayları

Preparation and Characterization of Montmorillonite/Polycaprolactone Composite Scaffold Containing Strontium for Bone Tissue Engineering Studies

Yazarlar: Aysel KOC DEMİR

Yayıncı: Turkish Chemical Society

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2016 Vol.3 Issue 3, pp.669-682

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000503896

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.287302

Sayı

Yazarlar:

Aysel KOC DEMİR

Yayıncı:

Turkish Chemical Society

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2016 Vol.3 Issue 3, pp.669-682

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000503896

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.287302