Efficacy of a modified albendazole and ivermectin formulation on treatment and the seasonal dynamics of sheep helminthosis

Victor Marchenko; Ivan Biryukov; Dmitry Kurinov; Marat Khalikov; Salavat Khalikov; Alireza Sazmand

Makale detayları

Efficacy of a modified albendazole and ivermectin formulation on treatment and the seasonal dynamics of sheep helminthosis

Yazarlar:

Victor Marchenko | Ivan Biryukov | Dmitry Kurinov | Marat Khalikov | Salavat Khalikov | Alireza Sazmand

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Medicine

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 4, pp.433-443

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359903

pISSN:

1300-0861

Anahtar kelimeler:

Özet:

 The aim of this study was to develop a complex antiparasitic compound containing albendazole ABZ and ivermectin IVM based on solid dispersion to increase the bioavailability of the active substances, to evaluate the efficacy of the formulation, and to monitor the effect of its use on the seasonal dynamics of sheep helminthosis for one year. To obtain the complex, a mechanochemical technology with joint grinding of ABZ, IVM, and polymer polyvinylpyrrolidone, PVP was used. The formulation was then used to study its efficacy in sheep helminthosis using coprological methods. Additionally, the sheep were treated both in spring and autumn to study the seasonal dynamics of infection with nematodes, cestodes, and trematodes. The suspension, administered at a rate of 0.2 mg IVM and 3 mg ABZkg body weight, showed 100 efficacy against the entire complex of helminths in both spring and autumn treatments. Furthermore, sheep admitted to winter stall maintenance presented fairly low rates of extensiveness 10.013.7 and intensity 9.514.7 EPG of infection with all types of helminths. The present study showed that administrations of the newly formulated anthelminthic CAPS-AI twice in the year, i.e., in the spring before going out to pasture and in the fall before placing them in stalls, ensured a relatively low level of sheep helminthoses, making it possible to prevent the clinical manifestation of helminthosis and subsequently economic losses.

 The aim of this study was to develop a complex antiparasitic compound containing albendazole ABZ and ivermectin IVM based on solid dispersion to increase the bioavailability of the active substances, to evaluate the efficacy of the formulation, and to monitor the effect of its use on the seasonal dynamics of sheep helminthosis for one year. To obtain the complex, a mechanochemical technology with joint grinding of ABZ, IVM, and polymer polyvinylpyrrolidone, PVP was used. The formulation was then used to study its efficacy in sheep helminthosis using coprological methods. Additionally, the sheep were treated both in spring and autumn to study the seasonal dynamics of infection with nematodes, cestodes, and trematodes. The suspension, administered at a rate of 0.2 mg IVM and 3 mg ABZkg body weight, showed 100 efficacy against the entire complex of helminths in both spring and autumn treatments. Furthermore, sheep admitted to winter stall maintenance presented fairly low rates of extensiveness 10.013.7 and intensity 9.514.7 EPG of infection with all types of helminths. The present study showed that administrations of the newly formulated anthelminthic CAPS-AI twice in the year, i.e., in the spring before going out to pasture and in the fall before placing them in stalls, ensured a relatively low level of sheep helminthoses, making it possible to prevent the clinical manifestation of helminthosis and subsequently economic losses.

 The aim of this study was to develop a complex antiparasitic compound containing albendazole ABZ and ivermectin IVM based on solid dispersion to increase the bioavailability of the active substances, to evaluate the efficacy of the formulation, and to monitor the effect of its use on the seasonal dynamics of sheep helminthosis for one year. To obtain the complex, a mechanochemical technology with joint grinding of ABZ, IVM, and polymer polyvinylpyrrolidone, PVP was used. The formulation was then used to study its efficacy in sheep helminthosis using coprological methods. Additionally, the sheep were treated both in spring and autumn to study the seasonal dynamics of infection with nematodes, cestodes, and trematodes. The suspension, administered at a rate of 0.2 mg IVM and 3 mg ABZkg body weight, showed 100 efficacy against the entire complex of helminths in both spring and autumn treatments. Furthermore, sheep admitted to winter stall maintenance presented fairly low rates of extensiveness 10.013.7 and intensity 9.514.7 EPG of infection with all types of helminths. The present study showed that administrations of the newly formulated anthelminthic CAPS-AI twice in the year, i.e., in the spring before going out to pasture and in the fall before placing them in stalls, ensured a relatively low level of sheep helminthoses, making it possible to prevent the clinical manifestation of helminthosis and subsequently economic losses.

 The aim of this study was to develop a complex antiparasitic compound containing albendazole ABZ and ivermectin IVM based on solid dispersion to increase the bioavailability of the active substances, to evaluate the efficacy of the formulation, and to monitor the effect of its use on the seasonal dynamics of sheep helminthosis for one year. To obtain the complex, a mechanochemical technology with joint grinding of ABZ, IVM, and polymer polyvinylpyrrolidone, PVP was used. The formulation was then used to study its efficacy in sheep helminthosis using coprological methods. Additionally, the sheep were treated both in spring and autumn to study the seasonal dynamics of infection with nematodes, cestodes, and trematodes. The suspension, administered at a rate of 0.2 mg IVM and 3 mg ABZkg body weight, showed 100 efficacy against the entire complex of helminths in both spring and autumn treatments. Furthermore, sheep admitted to winter stall maintenance presented fairly low rates of extensiveness 10.013.7 and intensity 9.514.7 EPG of infection with all types of helminths. The present study showed that administrations of the newly formulated anthelminthic CAPS-AI twice in the year, i.e., in the spring before going out to pasture and in the fall before placing them in stalls, ensured a relatively low level of sheep helminthoses, making it possible to prevent the clinical manifestation of helminthosis and subsequently economic losses.

Makale detayları

Efficacy of a modified albendazole and ivermectin formulation on treatment and the seasonal dynamics of sheep helminthosis

Yazarlar:

Victor Marchenko | Ivan Biryukov | Dmitry Kurinov | Marat Khalikov | Salavat Khalikov | Alireza Sazmand

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Medicine

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 4, pp.433-443

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359903

pISSN:

1300-0861

Anthelminthic

Mechanochemical modification

Novel formulation

Parasiticidal activity

Solid dispersion

Sayı

Makale detayları

Efficacy of a modified albendazole and ivermectin formulation on treatment and the seasonal dynamics of sheep helminthosis

Yazarlar: Victor Marchenko | Ivan Biryukov | Dmitry Kurinov | Marat Khalikov | Salavat Khalikov | Alireza Sazmand

Yayıncı: Ankara University

Ana Başlıklar: Veterinary Medicine

Dergi: Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 4, pp.433-443

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359903

pISSN: 1300-0861

Anthelminthic

Mechanochemical modification

Novel formulation

Parasiticidal activity

Solid dispersion

Sayı

Yazarlar:

Victor Marchenko | Ivan Biryukov | Dmitry Kurinov | Marat Khalikov | Salavat Khalikov | Alireza Sazmand

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Medicine

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.72 Issue 4, pp.433-443

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359903

pISSN:

1300-0861