Histopathological Diagnostic Correlation of Salivary Gland Fine Needle Aspiration Cytologies Evaluated According to the Milan Classification System

Özlem Saraydaroğlu; Selin Yirmibeş

Makale detayları

Histopathological Diagnostic Correlation of Salivary Gland Fine Needle Aspiration Cytologies Evaluated According to the Milan Classification System

Yazarlar:

Özlem Saraydaroğlu | Selin Yirmibeş

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Patoloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.49 Issue 3, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305791

pISSN:

1300-414X

Anahtar kelimeler:

Özet:

 The Milan Classification System has emerged with the purpose of using standart terminology and categorizing risk of malignancy for salivary gland lesions, when reporting fine needle aspiration cytology FNAC. This study aimed to evaluate the diagnostic compatibility of FNAC in salivary gland lesions and to determine the accuracy of cytological evaluation using the Milan System. A study group of 270 patients who underwent salivary gland FNAC and excisional biopsy in our center, between January 2011 and February 2023, was formed. FNAC diagnoses were compared to biopsy results. The sensitivity, specificity, positivenegative predictive values and accuracy of the test in detecting neoplasia and malignancy were calculated. Risk of malignancy was given as percentage for each diagnostic category. FNAC diagnoses of 270 cases were 9.6 non-diagnostic, 21.1 non-neoplastic, 2.2 atypia of undetermined significance, 48.5 benign, 2.6 uncertain malignant potential, 10.4 suspicious for malignancy, and 5.6 malignant. The histopathological diagnostic compatibility rate for non-neoplastic category was 40.4. Warthin tumor was the most frequently misdiagnosed entity as non-neoplastic. For benign cases, diagnostic compatibility was 87.8 and tumor subtype compatibility was 94.4. The most common diagnosis in the benign group was pleomorphic adenoma. For detecting malignancy, the sensitivity of FNAC was 64, specificity was 94.2, positive and negative predictive values were 74.4 and 90.8, and the accuracy of the method was 87.8. For detection of neoplasia, the sensitivity was 83.3, the specificity was 67.6, and the positive and negative predictive values were 93.9 and 40.3, respectively, and the accuracy rate of the method was 81.1. Reporting of FNAC in salivary gland lesions using the Milan System has been shown to provide high diagnostic accuracy in lesions with classical morphological features. This classification should be in all centers, especially in intermediate diagnoses and suspicious lesions, as it not only provides diagnostic standardization, but also indicates the risk of malignancy for each category.

 The Milan Classification System has emerged with the purpose of using standart terminology and categorizing risk of malignancy for salivary gland lesions, when reporting fine needle aspiration cytology FNAC. This study aimed to evaluate the diagnostic compatibility of FNAC in salivary gland lesions and to determine the accuracy of cytological evaluation using the Milan System. A study group of 270 patients who underwent salivary gland FNAC and excisional biopsy in our center, between January 2011 and February 2023, was formed. FNAC diagnoses were compared to biopsy results. The sensitivity, specificity, positivenegative predictive values and accuracy of the test in detecting neoplasia and malignancy were calculated. Risk of malignancy was given as percentage for each diagnostic category. FNAC diagnoses of 270 cases were 9.6 non-diagnostic, 21.1 non-neoplastic, 2.2 atypia of undetermined significance, 48.5 benign, 2.6 uncertain malignant potential, 10.4 suspicious for malignancy, and 5.6 malignant. The histopathological diagnostic compatibility rate for non-neoplastic category was 40.4. Warthin tumor was the most frequently misdiagnosed entity as non-neoplastic. For benign cases, diagnostic compatibility was 87.8 and tumor subtype compatibility was 94.4. The most common diagnosis in the benign group was pleomorphic adenoma. For detecting malignancy, the sensitivity of FNAC was 64, specificity was 94.2, positive and negative predictive values were 74.4 and 90.8, and the accuracy of the method was 87.8. For detection of neoplasia, the sensitivity was 83.3, the specificity was 67.6, and the positive and negative predictive values were 93.9 and 40.3, respectively, and the accuracy rate of the method was 81.1. Reporting of FNAC in salivary gland lesions using the Milan System has been shown to provide high diagnostic accuracy in lesions with classical morphological features. This classification should be in all centers, especially in intermediate diagnoses and suspicious lesions, as it not only provides diagnostic standardization, but also indicates the risk of malignancy for each category.

 The Milan Classification System has emerged with the purpose of using standart terminology and categorizing risk of malignancy for salivary gland lesions, when reporting fine needle aspiration cytology FNAC. This study aimed to evaluate the diagnostic compatibility of FNAC in salivary gland lesions and to determine the accuracy of cytological evaluation using the Milan System. A study group of 270 patients who underwent salivary gland FNAC and excisional biopsy in our center, between January 2011 and February 2023, was formed. FNAC diagnoses were compared to biopsy results. The sensitivity, specificity, positivenegative predictive values and accuracy of the test in detecting neoplasia and malignancy were calculated. Risk of malignancy was given as percentage for each diagnostic category. FNAC diagnoses of 270 cases were 9.6 non-diagnostic, 21.1 non-neoplastic, 2.2 atypia of undetermined significance, 48.5 benign, 2.6 uncertain malignant potential, 10.4 suspicious for malignancy, and 5.6 malignant. The histopathological diagnostic compatibility rate for non-neoplastic category was 40.4. Warthin tumor was the most frequently misdiagnosed entity as non-neoplastic. For benign cases, diagnostic compatibility was 87.8 and tumor subtype compatibility was 94.4. The most common diagnosis in the benign group was pleomorphic adenoma. For detecting malignancy, the sensitivity of FNAC was 64, specificity was 94.2, positive and negative predictive values were 74.4 and 90.8, and the accuracy of the method was 87.8. For detection of neoplasia, the sensitivity was 83.3, the specificity was 67.6, and the positive and negative predictive values were 93.9 and 40.3, respectively, and the accuracy rate of the method was 81.1. Reporting of FNAC in salivary gland lesions using the Milan System has been shown to provide high diagnostic accuracy in lesions with classical morphological features. This classification should be in all centers, especially in intermediate diagnoses and suspicious lesions, as it not only provides diagnostic standardization, but also indicates the risk of malignancy for each category.

 Tükürük bezi ince iğne aspirasyon sitolojisi İİAS raporlamasında, lezyonların malignite riskinin gruplandırılması ve standart terminolojinin kullanımı hedeflenerek Milan Sınıflandırma Sistemi ortaya çıkmıştır. Çalışmada, tükürük bezi lezyonlarında İİASnin tanı uyumluluğunun değerlendirilmesi ve Milan Sistemi kullanılarak sitolojik değerlendirmenin doğruluk oranının saptanması amaçlanmıştır. Ocak 2011- Şubat 2023 yılları arasında, merkezimizde tükürük bezi İİAS ve eksizyonel biyopsi uygulanmış olup histopatolojik tanısına ulaşılabilen 270 hastadan oluşan çalışma grubu oluşturuldu. İİAS tanıları biyopsi sonuçları ile karşılaştırıldı. Testin neoplaziyi ve maligniteyi saptamadaki duyarlılığı, özgüllüğü, pozitifnegatif belirleyicilik değerleri ve doğruluk oranı hesaplandı. Her tanı kategorisi için malignite riski değerleri yüzde olarak saptandı. 270 olgunun İİAS tanıları 9,6 tanısal olmayan, 21,1 non-neoplastik, 2,2 önemi belirsiz atipi, 48,5 benign, 2,6 malignite potansiyeli belirsiz, 10,4 malignite şüphesi ve 5,6 malign şeklindeydi. Non-neoplastik tanısı alan olguların histopatolojik tanı uyum oranı 40,4tü. Non-neoplastik tanısı alan olguların en sık karıştığı antite Warthin tümörü olarak belirlendi. Benign olgularda tanı uyumu 87,8, tümör alt tip uyum oranı ise 94,4tü. Benign grupta en sık saptanan tanı pleomorfik adenomdu. Malignitenin saptanmasında İİAS duyarlılığı 64, özgüllüğü 94,2, pozitif ve negatif belirleyicilik değerleri sırasıyla 74,4 ve 90,8, yöntemin doğruluk oranı ise 87,8 bulundu. Neoplazi saptanmasında ise duyarlılık 83,3, özgüllük 67,6, pozitif ve negatif belirleyicilik değerleri sırasıyla 93,9 ve 40,3, yöntemin doğruluk oranı 81,1 olarak saptandı. Tükürük bezi lezyonlarında İİASnin Milan Sistemi kullanılarak raporlanmasının, klasik morfolojik özellikler gösteren lezyonlarda yüksek tanısal doğruluk gösterdiği gösterilmiştir. Bu sınıflama, özellikle ara tanılarda ve şüpheli lezyonlarda, tanı standardizasyonunu sağlamanın yanı sıra her kategori için malignite riskini de belirttiğinden tüm merkezler tarafından kullanılmalıdır.

Makale detayları

Histopathological Diagnostic Correlation of Salivary Gland Fine Needle Aspiration Cytologies Evaluated According to the Milan Classification System

Yazarlar:

Özlem Saraydaroğlu | Selin Yirmibeş

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Patoloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.49 Issue 3, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305791

pISSN:

1300-414X

Cytology

Fine needle aspiration

Histopathology

Milan

Salivary glandİnce iğne aspirasyonu

Histopatoloji

Milan

Sitoloji

Tükürük bezi

Sayı

Makale detayları

Yazarlar: Özlem Saraydaroğlu | Selin Yirmibeş

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Patoloji

Dergi: Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.49 Issue 3, pp.285-290

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001305791

pISSN: 1300-414X

Sayı

Yazarlar:

Özlem Saraydaroğlu | Selin Yirmibeş

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Patoloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.49 Issue 3, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305791

pISSN:

1300-414X