Effect of parathyroidectomy on epicardial fat thickness as a cardiovascular risk factor in patients with primary hyperparathyroidism

Muhammed KIZILGÜL; Mustafa ÇALIŞKAN; Selvihan BEYSEL; Mustafa ÖZBEK; Erman ÇAKAL

Makale detayları

Effect of parathyroidectomy on epicardial fat thickness as a cardiovascular risk factor in patients with primary hyperparathyroidism

Yazarlar:

Muhammed KIZILGÜL | Mustafa ÇALIŞKAN | Selvihan BEYSEL | Mustafa ÖZBEK | Erman ÇAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1165-1169

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750021

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Several  studies  demonstrated  that  primary  hyperparathyroidism  is  related  to  increased  risk  for  cardiovascular  diseases (CVDs), and risk is decreased by parathyroidectomy. Epicardial fat thickness (EFT) has been postulated as a new marker of CVD risk. We evaluated the impact of parathyroidectomy on EFT in patients with primary hyperparathyroidism (PHPT).Materials  and  methods:  Thirty-four  PHPT  patients  (29  female,  5  male)  and  28  age-  and  sex-matched  controls  (19  female,  9  male)  were included in the study. Demographic, anthropometric, and biochemical data were recorded both before parathyroidectomy and 6 months after the procedure. Epicardial fat thickness was measured by transthoracic echocardiography.Results:  Mean  age  was  53.15  ±  8.44  years.  Mean  preoperative  EFT  was  higher  than  mean  EFT  in  the  control  group  (0.49  ±  0.07  cm  to  0.46  ±  0.08  cm,  P:  0.0005),  and  EFT  decreased  after  parathyroidectomy  (0.49  ±  0.07  cm  to  0.44  ±  0.08  cm,  P:  0.0005).  Systolic  blood pressure and calcium, parathormone, and hsCRP levels decreased after parathyroidectomy (P  0.05). Preoperatively, EFT was correlated with SBP (r: 0.360, P: 0.0285) and age (r: 0.466, P: 0.0036). Multiple linear regression used to identify independent predictors of change in epicardial fat did not find any predictor of change in epicardial fat (P > 0.05).Conclusion: EFT was decreased by parathyroidectomy in patients with primary hyperparathyroidism.However, the decrease in EFT was not correlated with any of the cardiovascular risk factors. More comprehensive studies evaluating the potential relation between PHPT and EFT need to be conducted.

Makale detayları

Effect of parathyroidectomy on epicardial fat thickness as a cardiovascular risk factor in patients with primary hyperparathyroidism

Yazarlar: Muhammed KIZILGÜL | Mustafa ÇALIŞKAN | Selvihan BEYSEL | Mustafa ÖZBEK | Erman ÇAKAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1165-1169

Belge Tipi: Makale

Yayın Tarihi: 7/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000750021

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Muhammed KIZILGÜL | Mustafa ÇALIŞKAN | Selvihan BEYSEL | Mustafa ÖZBEK | Erman ÇAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1165-1169

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750021

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144