The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients

Hamdi Afşin

Makale detayları

The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients

Yazarlar:

Hamdi Afşin

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Cardiology | Endocrinology | Nuclear Medicine

Dergi:

Abant Medical Journal Vol.12 Issue 2, pp.131-139

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293171

pISSN:

1305-4392

Anahtar kelimeler:

Özet:

 The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients Abstract Objective: Diabetes Mellitus DM is a significant risk factor for cardiovascular diseases, particularly myocardial ischemia. Both diabetes mellitus type 2 and cardiovascular conditions are characterized by a high burden of inflammation. The uric Acid to High-Density Lipoprotein cholesterol ratio UHR has been suggested as a novel marker of metabolic and inflammatory diseases. Hence, this study investigated the predictive role of the Uric Acid to High-Density Lipoprotein cholesterol ratio UHR in myocardial ischemia detected by Myocardial Perfusion Scintigraphy MPS in diabetic patients. Materials and Methods: This study included patients who underwent MPS between January 2022 and March 2023 at the Nuclear Medicine Department of Abant Izzet Baysal University Hospital. Based on the MPS results, the participants were divided into normal perfusion and myocardial ischemia. Variables such as age, sex, leukocyte count, hemoglobin, hematocrit, platelet count, serum uric acid, urea, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, transaminase, blood fasting glucose, C-reactive protein, and serum albumin were recorded and compared between the groups. Results: Among the 73 diabetic patients, 37 had myocardial ischemia, and 36 had normal MPS. Serum uric acid levels were higher in the ischemic group 6.3  1.5 mgdL than in the normal group 5.1  1.8 mgdL p0.05. The UHR in the ischemic group was significantly higher 0.15  0.05 than that in the normal MPS group 0.11  0.04. Serum UHR was significantly positively correlated with myocardial ischemia r0.36, p0.002 p0.05. With a cut-off value of  0.11, UHR exhibited 76 sensitivity and 58 specificity in detecting myocardial ischemia p0.05. Conclusions: High UHR is an independent predictor and diagnostic tool for myocardial ischemia in patients with diabetes and coronary artery disease. Routine use of UHR as an independent predictive marker is recommended for diabetic patients with myocardial ischemia who undergo MPS.

 The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients Abstract Objective: Diabetes Mellitus DM is a significant risk factor for cardiovascular diseases, particularly myocardial ischemia. Both diabetes mellitus type 2 and cardiovascular conditions are characterized by a high burden of inflammation. The uric Acid to High-Density Lipoprotein cholesterol ratio UHR has been suggested as a novel marker of metabolic and inflammatory diseases. Hence, this study investigated the predictive role of the Uric Acid to High-Density Lipoprotein cholesterol ratio UHR in myocardial ischemia detected by Myocardial Perfusion Scintigraphy MPS in diabetic patients. Materials and Methods: This study included patients who underwent MPS between January 2022 and March 2023 at the Nuclear Medicine Department of Abant Izzet Baysal University Hospital. Based on the MPS results, the participants were divided into normal perfusion and myocardial ischemia. Variables such as age, sex, leukocyte count, hemoglobin, hematocrit, platelet count, serum uric acid, urea, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, transaminase, blood fasting glucose, C-reactive protein, and serum albumin were recorded and compared between the groups. Results: Among the 73 diabetic patients, 37 had myocardial ischemia, and 36 had normal MPS. Serum uric acid levels were higher in the ischemic group 6.3  1.5 mgdL than in the normal group 5.1  1.8 mgdL p0.05. The UHR in the ischemic group was significantly higher 0.15  0.05 than that in the normal MPS group 0.11  0.04. Serum UHR was significantly positively correlated with myocardial ischemia r0.36, p0.002 p0.05. With a cut-off value of  0.11, UHR exhibited 76 sensitivity and 58 specificity in detecting myocardial ischemia p0.05. Conclusions: High UHR is an independent predictor and diagnostic tool for myocardial ischemia in patients with diabetes and coronary artery disease. Routine use of UHR as an independent predictive marker is recommended for diabetic patients with myocardial ischemia who undergo MPS.

 The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients Abstract Objective: Diabetes Mellitus DM is a significant risk factor for cardiovascular diseases, particularly myocardial ischemia. Both diabetes mellitus type 2 and cardiovascular conditions are characterized by a high burden of inflammation. The uric Acid to High-Density Lipoprotein cholesterol ratio UHR has been suggested as a novel marker of metabolic and inflammatory diseases. Hence, this study investigated the predictive role of the Uric Acid to High-Density Lipoprotein cholesterol ratio UHR in myocardial ischemia detected by Myocardial Perfusion Scintigraphy MPS in diabetic patients. Materials and Methods: This study included patients who underwent MPS between January 2022 and March 2023 at the Nuclear Medicine Department of Abant Izzet Baysal University Hospital. Based on the MPS results, the participants were divided into normal perfusion and myocardial ischemia. Variables such as age, sex, leukocyte count, hemoglobin, hematocrit, platelet count, serum uric acid, urea, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, transaminase, blood fasting glucose, C-reactive protein, and serum albumin were recorded and compared between the groups. Results: Among the 73 diabetic patients, 37 had myocardial ischemia, and 36 had normal MPS. Serum uric acid levels were higher in the ischemic group 6.3  1.5 mgdL than in the normal group 5.1  1.8 mgdL p0.05. The UHR in the ischemic group was significantly higher 0.15  0.05 than that in the normal MPS group 0.11  0.04. Serum UHR was significantly positively correlated with myocardial ischemia r0.36, p0.002 p0.05. With a cut-off value of  0.11, UHR exhibited 76 sensitivity and 58 specificity in detecting myocardial ischemia p0.05. Conclusions: High UHR is an independent predictor and diagnostic tool for myocardial ischemia in patients with diabetes and coronary artery disease. Routine use of UHR as an independent predictive marker is recommended for diabetic patients with myocardial ischemia who undergo MPS.

 Diyabetli Hastalarda Miyokard Perfüzyon Sintigrafisinde Miyokard İskemisini Öngörmede Ürik Asit-HDL Kolesterol Oranının Rolü Öz Amaç: Diabetes Mellitus DM başta miyokardiyal iskemi olmak üzere kardiyovasküler hastalıklar için önemli bir risk faktörüdür. Hem diabetes mellitus tip 2 hem de kardiyovasküler durumlar, yüksek bir inflamatuar yük ile karakterizedir. Ürik Asit -Yüksek Yoğunluklu Lipoprotein kolesterol oranı UHR, metabolik ve enflamatuar hastalıkların yeni bir belirteci olarak önerilmiştir. Bu nedenle, bu çalışma diyabetik hastalarda Miyokard Perfüzyon Sintigrafisi MPS ile saptanan miyokard iskemisinde Ürik Asidin Yüksek Yoğunluklu Lipoprotein kolesterol oranının UHR öngörmedeki rolünü araştırmıştır. Gereç ve Yöntemler: Bu çalışmaya Ocak 2022 ile Mart 2023 tarihleri arasında Abant İzzet Baysal Üniversitesi Hastanesi Nükleer Tıp Anabilim Dalında MPS uygulanan hastalar dahil edildi. MPS sonuçlarına göre katılımcılar normal perfüzyon ve miyokard iskemisi olarak iki gruba ayrıldı. Gruplar arasında yaş, cinsiyet, lökosit sayısı, hemoglobin, hematokrit, trombosit sayısı, serum ürik asit, üre, kreatinin, total kolesterol, LDL-kolesterol, HDL-kolesterol, trigliserit, transaminaz, kan açlık glikozu, C-reaktif protein ve serum albümini gibi değişkenler kaydedildi ve karşılaştırıldı. Bulgular: Diyabetli 73 hastanın 37sinde miyokardiyal iskemi, 36sında normal MPS mevcuttu. Serum ürik asit düzeyleri iskemik grupta 6.3  1.5 mgdL normal gruba 5.1  1.8 mgdL göre daha yüksekti p0.05. İskemik gruptaki UHR, normal MPS grubundakinden 0.11  0.04 anlamlı derecede yüksekti 0.15  0.05. Serum UHR, miyokard iskemisi ile anlamlı olarak pozitif korelasyon gösterdi r0.36, p0.002 p0.05. Cut off değeri  0.11 olan UHR, miyokard iskemisini saptamada  76 duyarlılık ve  58 özgüllük sergiledi p0.05. Sonuç: Yüksek UHR, diyabetli ve koroner arter hastalığı olan hastalarda miyokard iskemisi için bağımsız bir prediktör ve tanı aracıdır. Keywords: Uric Acid to High-Density Lipoprotein cholesterol ratio, Myocardial Ischemia, Myocardial Perfusion Scintigraphy, Diabetes Mellitus, Biomarkers.

Makale detayları

The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients

Yazarlar:

Hamdi Afşin

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Cardiology | Endocrinology | Nuclear Medicine

Dergi:

Abant Medical Journal Vol.12 Issue 2, pp.131-139

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293171

pISSN:

1305-4392

Uric Acid to High-Density Lipoprotein cholesterol ratio

Myocardial Ischemia

Myocardial Perfusion Scintigraphy

Diabetes Mellitus

BiomarkersUric Acid to High-Density Lipoprotein cholesterol ratio

Myocardial Ischemia

Myocardial Perfusion Scintigraphy

Diabetes Mellitus

Biomarkers

Sayı

Makale detayları

Yazarlar: Hamdi Afşin

Yayıncı: Bolu Abant Izzet Baysal University

Ana Başlıklar: Cardiology | Endocrinology | Nuclear Medicine

Dergi: Abant Medical Journal Vol.12 Issue 2, pp.131-139

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293171

pISSN: 1305-4392

Sayı

Yazarlar:

Hamdi Afşin

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Cardiology | Endocrinology | Nuclear Medicine

Dergi:

Abant Medical Journal Vol.12 Issue 2, pp.131-139

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293171

pISSN:

1305-4392