Formulation and characterization of puerarin loaded  nanoparticles encapsulated in PDLG employing solvent  evaporation method

N.A.

Makale detayları

Formulation and characterization of puerarin loaded nanoparticles encapsulated in PDLG employing solvent evaporation method

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.295-309

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339616

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Puerarin PU nanoparticles were prepared by solvent evaporation method using PDLG polymer, followed by lyophilization, in order to improve water solubility, systemic adsorption, and dissolution rate. PU pre formulation parameters were studied, and optimization study of PU nanoparticles PU-NPs was carried out by employing BoxBehnken design BBD, a response surface methodology. Under optimal conditions PU nanoparticles PU-NPs with mean particle size MPS 120.6 0.03 nm and particle size distribution PDI 0.22 were prepared. The entrapment efficiency, drug loading and drug content in the PU-NPs were found to be, 90.21, 14.56 and 98 respectively. The zeta potential at 25 was found to be -16.3 mV. PU-NPs were characterized by SEM, FTIR, XRD, TEM, stability, in-vitro release study and cytotoxicity. These results demonstrated that PU-NPs are non-cytotoxic and of smaller particle size than PU. Complete characterization of PU-NPs has shed light on their exceptional characteristics, thus making them a significant asset for subsequent research endeavors.

 Puerarin PU nanoparticles were prepared by solvent evaporation method using PDLG polymer, followed by lyophilization, in order to improve water solubility, systemic adsorption, and dissolution rate. PU pre formulation parameters were studied, and optimization study of PU nanoparticles PU-NPs was carried out by employing BoxBehnken design BBD, a response surface methodology. Under optimal conditions PU nanoparticles PU-NPs with mean particle size MPS 120.6 0.03 nm and particle size distribution PDI 0.22 were prepared. The entrapment efficiency, drug loading and drug content in the PU-NPs were found to be, 90.21, 14.56 and 98 respectively. The zeta potential at 25 was found to be -16.3 mV. PU-NPs were characterized by SEM, FTIR, XRD, TEM, stability, in-vitro release study and cytotoxicity. These results demonstrated that PU-NPs are non-cytotoxic and of smaller particle size than PU. Complete characterization of PU-NPs has shed light on their exceptional characteristics, thus making them a significant asset for subsequent research endeavors.

 Puerarin PU nanoparticles were prepared by solvent evaporation method using PDLG polymer, followed by lyophilization, in order to improve water solubility, systemic adsorption, and dissolution rate. PU pre formulation parameters were studied, and optimization study of PU nanoparticles PU-NPs was carried out by employing BoxBehnken design BBD, a response surface methodology. Under optimal conditions PU nanoparticles PU-NPs with mean particle size MPS 120.6 0.03 nm and particle size distribution PDI 0.22 were prepared. The entrapment efficiency, drug loading and drug content in the PU-NPs were found to be, 90.21, 14.56 and 98 respectively. The zeta potential at 25 was found to be -16.3 mV. PU-NPs were characterized by SEM, FTIR, XRD, TEM, stability, in-vitro release study and cytotoxicity. These results demonstrated that PU-NPs are non-cytotoxic and of smaller particle size than PU. Complete characterization of PU-NPs has shed light on their exceptional characteristics, thus making them a significant asset for subsequent research endeavors.

 Puerarin PU nanoparticles were prepared by solvent evaporation method using PDLG polymer, followed by lyophilization, in order to improve water solubility, systemic adsorption, and dissolution rate. PU pre formulation parameters were studied, and optimization study of PU nanoparticles PU-NPs was carried out by employing BoxBehnken design BBD, a response surface methodology. Under optimal conditions PU nanoparticles PU-NPs with mean particle size MPS 120.6 0.03 nm and particle size distribution PDI 0.22 were prepared. The entrapment efficiency, drug loading and drug content in the PU-NPs were found to be, 90.21, 14.56 and 98 respectively. The zeta potential at 25 was found to be -16.3 mV. PU-NPs were characterized by SEM, FTIR, XRD, TEM, stability, in-vitro release study and cytotoxicity. These results demonstrated that PU-NPs are non-cytotoxic and of smaller particle size than PU. Complete characterization of PU-NPs has shed light on their exceptional characteristics, thus making them a significant asset for subsequent research endeavors.

Makale detayları

Formulation and characterization of puerarin loaded nanoparticles encapsulated in PDLG employing solvent evaporation method

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.295-309

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339616

pISSN:

2630-6344

Puerarin

PDLG

Cytotoxicity

Solvent evaporation method

Puerarin nanoparticles

Novel formulation

Sayı

Makale detayları

Formulation and characterization of puerarin loaded nanoparticles encapsulated in PDLG employing solvent evaporation method

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.29 Issue 1, pp.295-309

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001339616

pISSN: 2630-6344

Puerarin

PDLG

Cytotoxicity

Solvent evaporation method

Puerarin nanoparticles

Novel formulation

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.295-309

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339616

pISSN:

2630-6344