Effects of quercetin on adipokine profile in fructose-induced metabolic syndrome

Melek Tunç Ata; Emine Kılıç Toprak; Mehmet Başeğmez; Ayşegül Çört; Vural Küçükatay

Makale detayları

Effects of quercetin on adipokine profile in fructose-induced metabolic syndrome

Yazarlar:

Melek Tunç Ata | Emine Kılıç Toprak | Mehmet Başeğmez | Ayşegül Çört | Vural Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.117-127

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318855

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: Metabolic syndrome MetS is a health condition characterized by obesity, insulin resistance, dyslipidemia and type 2 diabetes T2DM. This study aimed to assess the effects of quercetin, a natural flavonoid on MetS induced by fructose in Sprague Dawley rats. Materials and methods: The rats, aged 8-10 weeks, were divided into 4 groups: control C group, metabolic syndrome MetS group, controlquercetin CQ group, and metabolic syndromequercetin MetSQ group. The MetS groups received a 20 fructose solution in drinking water for a duration of 10 weeks. For the last 4 weeks of the study, rats in the Q groups were administered 50 mgkgbody weight quercetin. After 10 weeks, serum samples were tested using ELISA for Triglycerides TG, High-Density Lipoprotein HDL, fasting insulin, resistin, Interleukin 6 IL6, Tumor Necrosis Factor-alpha TNF-α, leptin, C-Reactive Protein CRP and, adiponectin ADP. The body weights, Lee index and HOMA-IR scores were also measured. Results: Fructose-fed rats showed significant increases in body weight, Lee index, HOMA-IR scores and, fasting insulin with significant decrease in HDL compared to controls. In MetS group, ADP levels were significantly lower compared to control group. In MetSQ group, there was a tendency for reduced levels of resistin, IL-6, and leptin compared to the untreated MetS group. Conclusion: These findings suggest that quercetin may be beneficial in managing MetS, though further research is needed to explore its mechanisms and effectiveness.

 Purpose: Metabolic syndrome MetS is a health condition characterized by obesity, insulin resistance, dyslipidemia and type 2 diabetes T2DM. This study aimed to assess the effects of quercetin, a natural flavonoid on MetS induced by fructose in Sprague Dawley rats. Materials and methods: The rats, aged 8-10 weeks, were divided into 4 groups: control C group, metabolic syndrome MetS group, controlquercetin CQ group, and metabolic syndromequercetin MetSQ group. The MetS groups received a 20 fructose solution in drinking water for a duration of 10 weeks. For the last 4 weeks of the study, rats in the Q groups were administered 50 mgkgbody weight quercetin. After 10 weeks, serum samples were tested using ELISA for Triglycerides TG, High-Density Lipoprotein HDL, fasting insulin, resistin, Interleukin 6 IL6, Tumor Necrosis Factor-alpha TNF-α, leptin, C-Reactive Protein CRP and, adiponectin ADP. The body weights, Lee index and HOMA-IR scores were also measured. Results: Fructose-fed rats showed significant increases in body weight, Lee index, HOMA-IR scores and, fasting insulin with significant decrease in HDL compared to controls. In MetS group, ADP levels were significantly lower compared to control group. In MetSQ group, there was a tendency for reduced levels of resistin, IL-6, and leptin compared to the untreated MetS group. Conclusion: These findings suggest that quercetin may be beneficial in managing MetS, though further research is needed to explore its mechanisms and effectiveness.

 Purpose: Metabolic syndrome MetS is a health condition characterized by obesity, insulin resistance, dyslipidemia and type 2 diabetes T2DM. This study aimed to assess the effects of quercetin, a natural flavonoid on MetS induced by fructose in Sprague Dawley rats. Materials and methods: The rats, aged 8-10 weeks, were divided into 4 groups: control C group, metabolic syndrome MetS group, controlquercetin CQ group, and metabolic syndromequercetin MetSQ group. The MetS groups received a 20 fructose solution in drinking water for a duration of 10 weeks. For the last 4 weeks of the study, rats in the Q groups were administered 50 mgkgbody weight quercetin. After 10 weeks, serum samples were tested using ELISA for Triglycerides TG, High-Density Lipoprotein HDL, fasting insulin, resistin, Interleukin 6 IL6, Tumor Necrosis Factor-alpha TNF-α, leptin, C-Reactive Protein CRP and, adiponectin ADP. The body weights, Lee index and HOMA-IR scores were also measured. Results: Fructose-fed rats showed significant increases in body weight, Lee index, HOMA-IR scores and, fasting insulin with significant decrease in HDL compared to controls. In MetS group, ADP levels were significantly lower compared to control group. In MetSQ group, there was a tendency for reduced levels of resistin, IL-6, and leptin compared to the untreated MetS group. Conclusion: These findings suggest that quercetin may be beneficial in managing MetS, though further research is needed to explore its mechanisms and effectiveness.

 Amaç: Metabolik sendrom MetS obezite, insülin direnci, dislipidemi ve tip 2 diyabet T2DM ile karakterize bir sağlık durumudur. Bu çalışmada, Sprague Dawley sıçanlarında fruktoz ile indüklenen MetS üzerinde doğal bir flavonoid olan quercetinin etkilerinin değerlendirilmesi amaçlandı. Gereç ve yöntem: 8-10 haftalık sıçanlar 4 gruba ayrıldı: kontrol C grubu, metabolik sendrom MetS grubu, kontrolquercetin CQ grubu ve metabolik sendromquercetin MetSQ grubu. MetS gruplarına 10 hafta boyunca içme suyunda 20 fruktoz çözeltisi verildi. Çalışmanın son 4 haftasında Q verilen gruplardaki sıçanlara 50 mgkgvücut ağırlığı quercetin uygulandı. 10 hafta sonra, serum örnekleri Trigliserid TG, Yüksek Yoğunluklu Lipoprotein HDL, açlık insülini, resistin, Interleukin 6 IL6, Tümör Nekroz Faktörü-alfa TNF-α, leptin, C-Reaktif Protein CRP ve adiponektin ADP için ELISA kullanılarak test edildi. Vücut ağırlıkları, Lee indeksi ve HOMA-IR skorları da ölçüldü. Bulgular: Fruktozla beslenen sıçanların vücut ağırlığında, Lee indeksinde, HOMA-IR skorlarında ve açlık insülininde kontrol grubuna kıyasla anlamlı artışlar, HDLde ise anlamlı düşüşler görüldü. MetS grubunda ADP seviyeleri kontrol grubuna kıyasla anlamlı derecede düşüktü. MetSQ grubunda, tedavi edilmeyen MetS grubuna kıyasla resistin, IL-6 ve leptin seviyelerinde azalma eğilimi vardı. Sonuç: Bu bulgular, quercetinin MetS yönetiminde faydalı olabileceğini, ancak mekanizmalarını ve etkinliğini keşfetmek için daha fazla araştırmaya ihtiyaç olduğunu göstermektedir.

Makale detayları

Effects of quercetin on adipokine profile in fructose-induced metabolic syndrome

Yazarlar:

Melek Tunç Ata | Emine Kılıç Toprak | Mehmet Başeğmez | Ayşegül Çört | Vural Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.117-127

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318855

pISSN:

1308-0865

Adipokine

fructose

metabolic syndrome

quercetinAdipokin

fruktoz

metabolik sendrom

quercetin

Sayı

Makale detayları

Yazarlar: Melek Tunç Ata | Emine Kılıç Toprak | Mehmet Başeğmez | Ayşegül Çört | Vural Küçükatay

Yayıncı: Pamukkale University

Ana Başlıklar: Tıbbi Fizyoloji (Diğer)

Dergi: Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.117-127

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001318855

pISSN: 1308-0865

Sayı

Yazarlar:

Melek Tunç Ata | Emine Kılıç Toprak | Mehmet Başeğmez | Ayşegül Çört | Vural Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

Tıbbi Fizyoloji (Diğer)

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.117-127

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318855

pISSN:

1308-0865