Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats

Hikmet Taner Teker; Taha Ceylani

Makale detayları

Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats

Yazarlar:

Hikmet Taner Teker | Taha Ceylani

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 3, pp.504-511

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292206

pISSN:

2147-835X

Anahtar kelimeler:

Özet:

 Intermittent fasting IF plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health.

 Intermittent fasting IF plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health.

 Intermittent fasting IF plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health.

 Intermittent fasting IF plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health.

Makale detayları

Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats

Yazarlar:

Hikmet Taner Teker | Taha Ceylani

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 3, pp.504-511

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292206

pISSN:

2147-835X

Intermittent fasting

aorta

ATR-FTIR

wistar rat

support vector machineIntermittent fasting

Aorta

ATR-FTIR

Wistar rat

Sayı

Makale detayları

Yazarlar: Hikmet Taner Teker | Taha Ceylani

Yayıncı: Sakarya University

Ana Başlıklar: Structural Biology

Dergi: Sakarya University Journal of Science Vol.27 Issue 3, pp.504-511

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292206

pISSN: 2147-835X

Sayı

Yazarlar:

Hikmet Taner Teker | Taha Ceylani

Yayıncı:

Sakarya University

Ana Başlıklar:

Structural Biology

Dergi:

Sakarya University Journal of Science Vol.27 Issue 3, pp.504-511

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292206

pISSN:

2147-835X