Cerebrospinal fluid and plasma lactate levels in human brain tumours

S. Yenice; G. GÜNER; Ü. ACAR; A. ERZURUM

Makale detayları

Cerebrospinal fluid and plasma lactate levels in human brain tumours

Yazarlar:

S. Yenice | G. GÜNER | Ü. ACAR | A. ERZURUM

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 1991 Vol.4 Issue 2, pp.60-64

Belge Tipi:

Makale

Yayın Tarihi:

3/1991

Belge Dili:

Türkçe

Document ID (Org No.):

2000528081

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

Özet:

 


Lactate is known to be formed from pyruvate in glycolysis in hypoxic conditions.

This study was carried out to investigate the possible change in lactate concentrations of cerebrospinal fluid and plasma in different types of brain tumours. Cerebrospinal fluid and plasma samples were obtained from patients admitted to Dokuz Eyliil University Neurosurgery Department and diagnosed to have brain tumours of various types. Twenty eight cases were divided into iwo distinct categories, as malignant (n=14) and benign (n=14) tumour groups. The control group consisted of fifteen neurologically normal subjects. Cerebrospinal fluid and plasma lactate levels were determined using the enzymatic UV method of Bergmeyer, employing lactate dehydrogenase. The mean cerebrospinal fluid and plasma lactate concentrations were found to be statistically elevated in two distinct type of brain tumour groups, when compared with the controls (p<0.05 and p<0.01, respectively).

These findings may reflect a generalized, or localized hypoxy in the tumoural state.

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Makale detayları

Cerebrospinal fluid and plasma lactate levels in human brain tumours

Yazarlar: S. Yenice | G. GÜNER | Ü. ACAR | A. ERZURUM

Yayıncı: Marmara University

Ana Başlıklar: Hastalıklar

Dergi: Marmara Medical Journal 1991 Vol.4 Issue 2, pp.60-64

Belge Tipi: Makale

Yayın Tarihi: 3/1991

Belge Dili: Türkçe

Document ID (Org No.): 2000528081

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

Sayı

Yazarlar:

S. Yenice | G. GÜNER | Ü. ACAR | A. ERZURUM

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 1991 Vol.4 Issue 2, pp.60-64

Belge Tipi:

Makale

Yayın Tarihi:

3/1991

Belge Dili:

Türkçe

Document ID (Org No.):

2000528081

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941