Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

Tekin GÜNEY; Murat ALIŞIK; Sema AKINCI; Salim NEŞELİOĞLU; İmdat DİLEK; Özcan EREL

Makale detayları

Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

Yazarlar:

Tekin GÜNEY | Murat ALIŞIK | Sema AKINCI | Salim NEŞELİOĞLU | İmdat DİLEK | Özcan EREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1280-1284

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752407

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background/aim: The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body.    Materials and methods: Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods.  Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients.   Conclusion: These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency.

 

Background/aim: The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body.    Materials and methods: Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods.  Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients.   Conclusion: These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency.

Makale detayları

Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

Yazarlar:

Tekin GÜNEY | Murat ALIŞIK | Sema AKINCI | Salim NEŞELİOĞLU | İmdat DİLEK | Özcan EREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1280-1284

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752407

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Vitamin B12

homocysteine

oxidative stress

total antioxidant status

total oxidant status

Sayı

Makale detayları

Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

Yazarlar: Tekin GÜNEY | Murat ALIŞIK | Sema AKINCI | Salim NEŞELİOĞLU | İmdat DİLEK | Özcan EREL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1280-1284

Belge Tipi: Makale

Yayın Tarihi: 12/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752407

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Vitamin B12

homocysteine

oxidative stress

total antioxidant status

total oxidant status

Sayı

Yazarlar:

Tekin GÜNEY | Murat ALIŞIK | Sema AKINCI | Salim NEŞELİOĞLU | İmdat DİLEK | Özcan EREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1280-1284

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752407

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144