Improve the solubility of cefpodoxime proxetil by amorphous solid dispersion technique

Ghaidaa Hameed

Makale detayları

Improve the solubility of cefpodoxime proxetil by amorphous solid dispersion technique

Yazarlar:

Ghaidaa Hameed

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1437-1450

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342437

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This research aimed to improve the solubility and stabilize cefpodoxime proxetil CP, a class IV drug, by amorphous solid dispersion ASD technique. Four formulations were prepared by dispersing amorphous CP in soluplus, polyvinylpyrrolidone PVP K30, and ethyl cellulose EC blends in different compositions and ratios. The optimum formulation was stored in accelerated conditions at 40 C and 75 relative humidity for six months. The drugs solubility and dissolution rate in different systems were explored. Furthermore, Differential Scanning Calorimetry DSC, X-ray Powder Diffractometry PXRD, Fourier Transform Infrared spectroscopy FTIR, and Field Emission Scanning Electron Microscopy FESEM were used to examine the physical state of the drug. The antibacterial activity of the drug was evaluated during the experiment. When mixing CP with soluplus and PVP K30 in a 1:1:1 ratio as ASD, the drug solubility at pH 1.2 enhanced about 28 folds than a pure drug, and the dissolution rate increment was observed. The DSC, FTIR, and PXRD data confirmed the drug is amorphous and miscible with these polymers. FESEM revealed particle size reduction. The antibacterial activity was raised. After storage in the accelerated condition, physical investigations indicated that no recrystallization occurred, and this condition had little effect on in vitro drug dissolution and antibacterial activity. This can be a good indicator of the drugs solubility enhancement and physical stability optimization that will make the possibility of preparing this drug in the future as an oral solid dosage form with the possibility of manufacturing with a drug company due to the promising results.

 This research aimed to improve the solubility and stabilize cefpodoxime proxetil CP, a class IV drug, by amorphous solid dispersion ASD technique. Four formulations were prepared by dispersing amorphous CP in soluplus, polyvinylpyrrolidone PVP K30, and ethyl cellulose EC blends in different compositions and ratios. The optimum formulation was stored in accelerated conditions at 40 C and 75 relative humidity for six months. The drugs solubility and dissolution rate in different systems were explored. Furthermore, Differential Scanning Calorimetry DSC, X-ray Powder Diffractometry PXRD, Fourier Transform Infrared spectroscopy FTIR, and Field Emission Scanning Electron Microscopy FESEM were used to examine the physical state of the drug. The antibacterial activity of the drug was evaluated during the experiment. When mixing CP with soluplus and PVP K30 in a 1:1:1 ratio as ASD, the drug solubility at pH 1.2 enhanced about 28 folds than a pure drug, and the dissolution rate increment was observed. The DSC, FTIR, and PXRD data confirmed the drug is amorphous and miscible with these polymers. FESEM revealed particle size reduction. The antibacterial activity was raised. After storage in the accelerated condition, physical investigations indicated that no recrystallization occurred, and this condition had little effect on in vitro drug dissolution and antibacterial activity. This can be a good indicator of the drugs solubility enhancement and physical stability optimization that will make the possibility of preparing this drug in the future as an oral solid dosage form with the possibility of manufacturing with a drug company due to the promising results.

 This research aimed to improve the solubility and stabilize cefpodoxime proxetil CP, a class IV drug, by amorphous solid dispersion ASD technique. Four formulations were prepared by dispersing amorphous CP in soluplus, polyvinylpyrrolidone PVP K30, and ethyl cellulose EC blends in different compositions and ratios. The optimum formulation was stored in accelerated conditions at 40 C and 75 relative humidity for six months. The drugs solubility and dissolution rate in different systems were explored. Furthermore, Differential Scanning Calorimetry DSC, X-ray Powder Diffractometry PXRD, Fourier Transform Infrared spectroscopy FTIR, and Field Emission Scanning Electron Microscopy FESEM were used to examine the physical state of the drug. The antibacterial activity of the drug was evaluated during the experiment. When mixing CP with soluplus and PVP K30 in a 1:1:1 ratio as ASD, the drug solubility at pH 1.2 enhanced about 28 folds than a pure drug, and the dissolution rate increment was observed. The DSC, FTIR, and PXRD data confirmed the drug is amorphous and miscible with these polymers. FESEM revealed particle size reduction. The antibacterial activity was raised. After storage in the accelerated condition, physical investigations indicated that no recrystallization occurred, and this condition had little effect on in vitro drug dissolution and antibacterial activity. This can be a good indicator of the drugs solubility enhancement and physical stability optimization that will make the possibility of preparing this drug in the future as an oral solid dosage form with the possibility of manufacturing with a drug company due to the promising results.

 This research aimed to improve the solubility and stabilize cefpodoxime proxetil CP, a class IV drug, by amorphous solid dispersion ASD technique. Four formulations were prepared by dispersing amorphous CP in soluplus, polyvinylpyrrolidone PVP K30, and ethyl cellulose EC blends in different compositions and ratios. The optimum formulation was stored in accelerated conditions at 40 C and 75 relative humidity for six months. The drugs solubility and dissolution rate in different systems were explored. Furthermore, Differential Scanning Calorimetry DSC, X-ray Powder Diffractometry PXRD, Fourier Transform Infrared spectroscopy FTIR, and Field Emission Scanning Electron Microscopy FESEM were used to examine the physical state of the drug. The antibacterial activity of the drug was evaluated during the experiment. When mixing CP with soluplus and PVP K30 in a 1:1:1 ratio as ASD, the drug solubility at pH 1.2 enhanced about 28 folds than a pure drug, and the dissolution rate increment was observed. The DSC, FTIR, and PXRD data confirmed the drug is amorphous and miscible with these polymers. FESEM revealed particle size reduction. The antibacterial activity was raised. After storage in the accelerated condition, physical investigations indicated that no recrystallization occurred, and this condition had little effect on in vitro drug dissolution and antibacterial activity. This can be a good indicator of the drugs solubility enhancement and physical stability optimization that will make the possibility of preparing this drug in the future as an oral solid dosage form with the possibility of manufacturing with a drug company due to the promising results.

Makale detayları

Improve the solubility of cefpodoxime proxetil by amorphous solid dispersion technique

Yazarlar:

Ghaidaa Hameed

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1437-1450

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342437

pISSN:

2630-6344

Amorphous solid dispersion (ASD) technique

cefpodoxime proxetil

physical stability

solubility

Sayı

Makale detayları

Improve the solubility of cefpodoxime proxetil by amorphous solid dispersion technique

Yazarlar: Ghaidaa Hameed

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 4, pp.1437-1450

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342437

pISSN: 2630-6344

Amorphous solid dispersion (ASD) technique

cefpodoxime proxetil

physical stability

solubility

Sayı

Yazarlar:

Ghaidaa Hameed

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1437-1450

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342437

pISSN:

2630-6344