Global Ischemia and Turn Preference; A  Comparative Study of the Effects of Global  Ischemic Insult in Rats

Akçahan GEPDİREMEN

Makale detayları

Global Ischemia and Turn Preference; A Comparative Study of the Effects of Global Ischemic Insult in Rats

Yazarlar:

Akçahan GEPDİREMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.355-362

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758299

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

We examined the effect of global  cerebral ischemia (Two vessel occlusion plus  systemic hypotension method) for 15  minutes on the hippocampal CA1 and CA3  neurones in rats, and compared with turn  prefence scores. 14 of 27 animals were  ambidexter while 9 had left and 4 had right  turn preference. The left turns were  significantly different from rights (t:2,26  df:26 p:0,032). Male rats prefered 62,73%  and females 56,88% left turns. Forty-eight  hours following the global cerebral ischemic  insult, animals were sacrificed and brains  were examined by using light microscope.  Hippocampal neurones of the right  hemisphere were survived more in males  while left side neurones did it in female rats.  Most impressive result in this study was that  the CA1 hippocampal neurones were better  protected than CA3 neurones in cerebral  ischemic insult (t:4,69 df:53 p:0.000). This  significance was especially originated from  right hemisphere (t:4,55 df:26 p:0,000). In  ambidexter rat group, left CA3 was better  protected than right CA3 (t:2,17 df:13  p:0,049). Right CA3 neurones were  significantly survived better in right turn  prefence dominant than ambidexter rats  (t:2,22 df:16 p:0,041).

 

We examined the effect of global  cerebral ischemia (Two vessel occlusion plus  systemic hypotension method) for 15  minutes on the hippocampal CA1 and CA3  neurones in rats, and compared with turn  prefence scores. 14 of 27 animals were  ambidexter while 9 had left and 4 had right  turn preference. The left turns were  significantly different from rights (t:2,26  df:26 p:0,032). Male rats prefered 62,73%  and females 56,88% left turns. Forty-eight  hours following the global cerebral ischemic  insult, animals were sacrificed and brains  were examined by using light microscope.  Hippocampal neurones of the right  hemisphere were survived more in males  while left side neurones did it in female rats.  Most impressive result in this study was that  the CA1 hippocampal neurones were better  protected than CA3 neurones in cerebral  ischemic insult (t:4,69 df:53 p:0.000). This  significance was especially originated from  right hemisphere (t:4,55 df:26 p:0,000). In  ambidexter rat group, left CA3 was better  protected than right CA3 (t:2,17 df:13  p:0,049). Right CA3 neurones were  significantly survived better in right turn  prefence dominant than ambidexter rats  (t:2,22 df:16 p:0,041).

Makale detayları

Global Ischemia and Turn Preference; A Comparative Study of the Effects of Global Ischemic Insult in Rats

Yazarlar:

Akçahan GEPDİREMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.355-362

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758299

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Hippocampus

Global ischemia

Neuronal death

Turn preference

CA1

CA3.

Sayı

Makale detayları

Global Ischemia and Turn Preference; A Comparative Study of the Effects of Global Ischemic Insult in Rats

Yazarlar: Akçahan GEPDİREMEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.355-362

Belge Tipi: Makale

Yayın Tarihi: 3/1998

Belge Dili: Türkçe

Document ID (Org No.): 2000758299

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Hippocampus

Global ischemia

Neuronal death

Turn preference

CA1

CA3.

Sayı

Yazarlar:

Akçahan GEPDİREMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.355-362

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758299

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144