The Cuttlefish Backbone: A New Bone Xenograft Material?

Zafer OKUMUŞ

Makale detayları

The Cuttlefish Backbone: A New Bone Xenograft Material?

Yazarlar:

Zafer OKUMUŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 5, pp.1177-1184

Belge Tipi:

Makale

Yayın Tarihi:

4/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768712

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

This experiment was conducted to determine the feasibility of cuttlefish backbone as a new xenograft in the treatment of bone defects and its therapeutic effectiveness.  Following the administration of general anaesthesia to 20 one-year-old  male New Zealand rabbits, traumatic defective areas (5 mm in diameter) were experimentally induced at the proximal and distal metaphyses of both femurs. These defective areas (n = 80) were randomly assigned to be filled with cuttlefish backbone, spongious bovine graft (SBG), tricalcium phosphate (TCP) and demineralised bone matrix (DBM) in a complete randomised design. At the end of the 30-day postoperative experimental period, bone defects filled with various graft materials were evaluated using macroscopic, radiographic, MRI, and scintigraphic methods and then the rabbits were subjected to euthanasia for histological examination. In response to the application of these graft materials, callus formation was observed in a similar fashion across all defective areas. Moreover, cuttlefish backbone ranked second after spongious bovine graft with respect to osteogenic capacity and the bone repairing process. In conclusion, our preliminary data on callus formation, osteogenic capacity and bone repairing suggest that cuttlefish backbone could be considered an alternative xenograft material in orthopaedic applications.

 

This experiment was conducted to determine the feasibility of cuttlefish backbone as a new xenograft in the treatment of bone defects and its therapeutic effectiveness.  Following the administration of general anaesthesia to 20 one-year-old  male New Zealand rabbits, traumatic defective areas (5 mm in diameter) were experimentally induced at the proximal and distal metaphyses of both femurs. These defective areas (n = 80) were randomly assigned to be filled with cuttlefish backbone, spongious bovine graft (SBG), tricalcium phosphate (TCP) and demineralised bone matrix (DBM) in a complete randomised design. At the end of the 30-day postoperative experimental period, bone defects filled with various graft materials were evaluated using macroscopic, radiographic, MRI, and scintigraphic methods and then the rabbits were subjected to euthanasia for histological examination. In response to the application of these graft materials, callus formation was observed in a similar fashion across all defective areas. Moreover, cuttlefish backbone ranked second after spongious bovine graft with respect to osteogenic capacity and the bone repairing process. In conclusion, our preliminary data on callus formation, osteogenic capacity and bone repairing suggest that cuttlefish backbone could be considered an alternative xenograft material in orthopaedic applications.

Makale detayları

The Cuttlefish Backbone: A New Bone Xenograft Material?

Yazarlar:

Zafer OKUMUŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 5, pp.1177-1184

Belge Tipi:

Makale

Yayın Tarihi:

4/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768712

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Cuttlefish backbone

bone defect

bone xenograft

Sayı

Makale detayları

The Cuttlefish Backbone: A New Bone Xenograft Material?

Yazarlar: Zafer OKUMUŞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 5, pp.1177-1184

Belge Tipi: Makale

Yayın Tarihi: 4/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000768712

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Cuttlefish backbone

bone defect

bone xenograft

Sayı

Yazarlar:

Zafer OKUMUŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2005 Vol.29 Issue 5, pp.1177-1184

Belge Tipi:

Makale

Yayın Tarihi:

4/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000768712

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128