Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model

N.A.

Makale detayları

Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1842-1856

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347794

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Dementia involves impairment in cognitive and behavioral abilities, which leads to disability and dependency, particularly among older people. Alzheimers disease is the most common form of dementia. Currently, available synthetic drugs against dementia have several side effects and only give symptomatic relief without curing or reversing the pathophysiology of the disease. So, herbal drugs can be good alternatives with a good safety profile. Curcuma longa CL and Withania somnifera WS have been reported for neurological activities with individual extracts and select phytoconstituents. However, their aqueous-ethanolic extracts have not been studied in dementia models. This study aimed to find the effect of aqueous-ethanol extracts of CL rhizomes and WS roots in scopolamine-induced dementia in Swiss albino mice using behavior models; Elevated Plus Maze EPM, Morris Water Maze MWM and Spontaneous Alternation Y Maze. Further, their antioxidant activity was also studied. The findings of the study revealed that both extracts effectively antagonized the detrimental effects of Scopolamine. Comparatively, WS in the dose of 40 mgkg exhibited more efficacy in EPM and MWM models, while CL at 40 mgkg was found to be more effective in the Y Maze. Furthermore, both extracts showed higher effects at the dose of 40 mgkg than 20 mgkg. They have also exhibited antioxidant activity. It is concluded that the aqueous-ethanolic extracts of CL and WS possess antidementia and antioxidant potential like other extracts earlier reported. Their pathophysiology, synergistic effects in different combinations, and influence on the neurotransmitters need further exploration.

 Dementia involves impairment in cognitive and behavioral abilities, which leads to disability and dependency, particularly among older people. Alzheimers disease is the most common form of dementia. Currently, available synthetic drugs against dementia have several side effects and only give symptomatic relief without curing or reversing the pathophysiology of the disease. So, herbal drugs can be good alternatives with a good safety profile. Curcuma longa CL and Withania somnifera WS have been reported for neurological activities with individual extracts and select phytoconstituents. However, their aqueous-ethanolic extracts have not been studied in dementia models. This study aimed to find the effect of aqueous-ethanol extracts of CL rhizomes and WS roots in scopolamine-induced dementia in Swiss albino mice using behavior models; Elevated Plus Maze EPM, Morris Water Maze MWM and Spontaneous Alternation Y Maze. Further, their antioxidant activity was also studied. The findings of the study revealed that both extracts effectively antagonized the detrimental effects of Scopolamine. Comparatively, WS in the dose of 40 mgkg exhibited more efficacy in EPM and MWM models, while CL at 40 mgkg was found to be more effective in the Y Maze. Furthermore, both extracts showed higher effects at the dose of 40 mgkg than 20 mgkg. They have also exhibited antioxidant activity. It is concluded that the aqueous-ethanolic extracts of CL and WS possess antidementia and antioxidant potential like other extracts earlier reported. Their pathophysiology, synergistic effects in different combinations, and influence on the neurotransmitters need further exploration.

 Dementia involves impairment in cognitive and behavioral abilities, which leads to disability and dependency, particularly among older people. Alzheimers disease is the most common form of dementia. Currently, available synthetic drugs against dementia have several side effects and only give symptomatic relief without curing or reversing the pathophysiology of the disease. So, herbal drugs can be good alternatives with a good safety profile. Curcuma longa CL and Withania somnifera WS have been reported for neurological activities with individual extracts and select phytoconstituents. However, their aqueous-ethanolic extracts have not been studied in dementia models. This study aimed to find the effect of aqueous-ethanol extracts of CL rhizomes and WS roots in scopolamine-induced dementia in Swiss albino mice using behavior models; Elevated Plus Maze EPM, Morris Water Maze MWM and Spontaneous Alternation Y Maze. Further, their antioxidant activity was also studied. The findings of the study revealed that both extracts effectively antagonized the detrimental effects of Scopolamine. Comparatively, WS in the dose of 40 mgkg exhibited more efficacy in EPM and MWM models, while CL at 40 mgkg was found to be more effective in the Y Maze. Furthermore, both extracts showed higher effects at the dose of 40 mgkg than 20 mgkg. They have also exhibited antioxidant activity. It is concluded that the aqueous-ethanolic extracts of CL and WS possess antidementia and antioxidant potential like other extracts earlier reported. Their pathophysiology, synergistic effects in different combinations, and influence on the neurotransmitters need further exploration.

 Dementia involves impairment in cognitive and behavioral abilities, which leads to disability and dependency, particularly among older people. Alzheimers disease is the most common form of dementia. Currently, available synthetic drugs against dementia have several side effects and only give symptomatic relief without curing or reversing the pathophysiology of the disease. So, herbal drugs can be good alternatives with a good safety profile. Curcuma longa CL and Withania somnifera WS have been reported for neurological activities with individual extracts and select phytoconstituents. However, their aqueous-ethanolic extracts have not been studied in dementia models. This study aimed to find the effect of aqueous-ethanol extracts of CL rhizomes and WS roots in scopolamine-induced dementia in Swiss albino mice using behavior models; Elevated Plus Maze EPM, Morris Water Maze MWM and Spontaneous Alternation Y Maze. Further, their antioxidant activity was also studied. The findings of the study revealed that both extracts effectively antagonized the detrimental effects of Scopolamine. Comparatively, WS in the dose of 40 mgkg exhibited more efficacy in EPM and MWM models, while CL at 40 mgkg was found to be more effective in the Y Maze. Furthermore, both extracts showed higher effects at the dose of 40 mgkg than 20 mgkg. They have also exhibited antioxidant activity. It is concluded that the aqueous-ethanolic extracts of CL and WS possess antidementia and antioxidant potential like other extracts earlier reported. Their pathophysiology, synergistic effects in different combinations, and influence on the neurotransmitters need further exploration.

Makale detayları

Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1842-1856

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347794

pISSN:

2630-6344

dementia

Alzheimer's disease

Curcuma longa

Curcumin

Withania somnifera

Withanolides

Sayı

Makale detayları

Aqueous-ethanolic extracts of Curcuma longa and Withania somnifera improve memory in the dementia model

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.26 Issue 6, pp.1842-1856

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347794

pISSN: 2630-6344

dementia

Alzheimer's disease

Curcuma longa

Curcumin

Withania somnifera

Withanolides

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1842-1856

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347794

pISSN:

2630-6344