Role of red cell dstribution width in colorectal cancer diagnosis and prognosis

Ahmet KARAYİĞİT; Dursun Burak ÖZDEMİR; Hayrettin DİZEN; Bülent ÜNAL; İlter OZER; Murat ULAŞ

doi:https://doi.org/10.32322/jhsm.1102938

Makale detayları

Role of red cell dstribution width in colorectal cancer diagnosis and prognosis

Yazarlar:

Ahmet KARAYİĞİT | Dursun Burak ÖZDEMİR | Hayrettin DİZEN | Bülent ÜNAL | İlter OZER | Murat ULAŞ

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences and Medicine 2022 Vol.5 Issue 3, pp.875-881

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000481478

Sıklık:

İki Aylık

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.1102938

Özet:

 

Objective: We aimed to assess whether red cell distribution width (RDW) was associated with pre-operative clinical features or post-operative clinicopathological outcomes in patients with colorectal cancer (CRC), and to determine the utility of RDW as a diagnostic or prognostic marker of CRC.
Material and Method: This retrospective cohort study was conducted between January 2018 and May 2021 at a university hospital in Turkey. A total of 188 patients histologically diagnosed with CRC who had undergone surgery were included in the study. 
Results: Our study included 118 (62.77%) male patients, and the mean age of the patients was 66.28±11.71 years. We found that RDW values were significantly higher in females compared to males (p=0.033), in patients with T3 or T4 tumors compared to those with T1 or T2 tumors (p<0.001), in patients with stage 2 and stage 3 tumors compared to stage 1 patients, those with early mortality (p=0.012), in patients with right or transverse colon tumors compared to those with descending colon or sigmoid colon or rectum tumors (p<0.001), and those that died during follow-up compared to survivors (p=0.001). Additionally, age (r=0.233, p<0.001), tumor size (r=0.229, p=0.002) and length of stay in hospital (r=0.167, p=0.022) were positively correlated with RDW values. RDW had 75.7% sensitivity and 67.5% specificity to predict mortality for the cut-off point of 15.7 (AUC: 0.704, 95.0%CI: 0.615-0.793, p<0.001).
Conclusion: These results show that RDW has a potential function as a biomarker for the diagnosis and prognosis of CRC.

Makale detayları

Role of red cell dstribution width in colorectal cancer diagnosis and prognosis

Yazarlar: Ahmet KARAYİĞİT | Dursun Burak ÖZDEMİR | Hayrettin DİZEN | Bülent ÜNAL | İlter OZER | Murat ULAŞ

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Health Sciences and Medicine 2022 Vol.5 Issue 3, pp.875-881

Belge Tipi: Makale

Yayın Tarihi: 5/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000481478

Sıklık: İki Aylık

eISSN: 2636-8579

DOI: https://doi.org/10.32322/jhsm.1102938

Sayı

Yazarlar:

Ahmet KARAYİĞİT | Dursun Burak ÖZDEMİR | Hayrettin DİZEN | Bülent ÜNAL | İlter OZER | Murat ULAŞ

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences and Medicine 2022 Vol.5 Issue 3, pp.875-881

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000481478

Sıklık:

İki Aylık

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.1102938