Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

Shaymaa Fadhel ABBAS ALBAAYİT; Mariam KHAN; Rasedee ABDULLAH

doi:https://doi.org/10.37929/nveo.927770

Makale detayları

Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

Yazarlar:

Shaymaa Fadhel ABBAS ALBAAYİT | Mariam KHAN | Rasedee ABDULLAH

Yayıncı:

Badebio Biotechnology Ltd.

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Natural Volatiles and Essential Oils 2021 Vol.8 Issue 3, pp.56-63

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000829173

Sıklık:

Üç Aylık

eISSN:

2148-9637

DOI:

https://doi.org/10.37929/nveo.927770

Özet:

 

Zerumbone (ZER), a natural compound has been extracted from Zingiber zerumbet with known pharmacological activities. The aim was to determine the anti-human Burkitt’s lymphoma (Raji) cell effect of ZER. The 3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyltetrazolium bromide (MTT) assay was used to determine cytotoxic effect while the Annexin-V-fluorescein isothiocyanate/propidium iodide-PI flow cytometric assays was used to determine apoptotic effect of ZER on the human Burkitt’s lymphoma (Raji) cell (ATCC CCL-86) cell line. The expressions of Bax, Bcl-2, and c-Myc genes were determined via real-time PCR. ZER suppressed the proliferation of Raji cells with a 48 h IC50 value of 5.1 μg/mL. Treated Raji cells also underwent late apoptosis especially after treatment with 100 μg/mL ZER. The apoptotic effect of ZER is associated with increase in Bax and decrease in Bcl-2 and c-Myc gene expressions. These results suggest that ZER inhibited the proliferation of Raji cells through the modification of apoptosis-related gene expressions. Therefore, ZER has potential as a candidate for the treatment of Burkitt’s lymphoma.

Makale detayları

Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

Yazarlar: Shaymaa Fadhel ABBAS ALBAAYİT | Mariam KHAN | Rasedee ABDULLAH

Yayıncı: Badebio Biotechnology Ltd.

Ana Başlıklar: Sağlık teşvikleri

Dergi: Natural Volatiles and Essential Oils 2021 Vol.8 Issue 3, pp.56-63

Belge Tipi: Makale

Yayın Tarihi: 9/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000829173

Sıklık: Üç Aylık

eISSN: 2148-9637

DOI: https://doi.org/10.37929/nveo.927770

Sayı

Yazarlar:

Shaymaa Fadhel ABBAS ALBAAYİT | Mariam KHAN | Rasedee ABDULLAH

Yayıncı:

Badebio Biotechnology Ltd.

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Natural Volatiles and Essential Oils 2021 Vol.8 Issue 3, pp.56-63

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000829173

Sıklık:

Üç Aylık

eISSN:

2148-9637

DOI:

https://doi.org/10.37929/nveo.927770