The relationship of cathepsin-k level with some biochemical and hematogical variables in women with osteoporosis, pregnant and menopausal

Ali Al-khafaji; Rima Nour Elhouda Tiri; Ayşenur Aygün; Ebru Halvacı; Fatih Şen

Makale detayları

The relationship of cathepsin-k level with some biochemical and hematogical variables in women with osteoporosis, pregnant and menopausal

Yazarlar:

Ali Al-khafaji | Rima Nour Elhouda Tiri | Ayşenur Aygün | Ebru Halvacı | Fatih Şen

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Analytical Biochemistry | Medical Biochemistry - Nucleic Acids | Plant Protection (Other)

Dergi:

Journal of Scientific Reports-B Issue 011, pp.35-53

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326280

pISSN:

2717-8625

Anahtar kelimeler:

Özet:

 In this study, the biochemical and hematological variables in 180 patients women between 17 and 75 years old were hospitalized at Al-Sadr Teaching Hospital in Najaf Iraq between April and July 2023. The patients were devised in 4 different group studies with 180 patients in each group consisting of 45 women: female with osteoporosis in the range age 22-35, a pregnant female in range age 17-37, female menopause range age 45-75, and healthy females in range age 19-65 as the control group. The biochemical variables such as level of Cathepsin K Cath-k concentration, Estradiol E2 concentration, vitamin D Vit -D, and parathyroid hormone PTH concentration in women with osteoporosis, menopause, pregnant and healthy women were evaluated. In addition, the hematological variables: red blood cells RBCs, hemoglobin Hb, hematocrit HCT, number of platelets PLT, and number of white blood cells WBCs were evaluated in different study groups. Also, the concentration of phosphate P and Body Mass Index BMI was estimated. In the end, the correlation test with each variable in different group studies was calculated by the STATISTICA program. The obtained results showed that there was a significant increase in the numbers of WBCs, the concentration of Cath-k, PTH, and BMI for the study groups compared to the control group, as well as a significant decrease in the concentration of P and Vit -D for the study groups compared to the control group. There is a significant increase in the E2 hormone in the group of pregnant women and a significant decrease in women with osteoporosis who are in menopause compared to the control group, as well as the presence of a significant decrease in RBCs, and Hb in the group of pregnant women compared to the control group. There is a significant increase in the numbers of PLT in the group of women with osteoporosis and women in menopause compared to the control group, as it is concluded from the current study that there is a close correlation between some different variables, including a good correlation between BMI and PLT was found to be 0.83. This may confirm that BMI is associated with increased cardiovascular morbidity and mortality through various molecular mechanisms possibly linking metabolic syndrome to hemostatic and vascular abnormalities in addition, a good correlation was observed between PTH and Cat-k 0.89, which indicated there is a relation between these two parameters.

 In this study, the biochemical and hematological variables in 180 patients women between 17 and 75 years old were hospitalized at Al-Sadr Teaching Hospital in Najaf Iraq between April and July 2023. The patients were devised in 4 different group studies with 180 patients in each group consisting of 45 women: female with osteoporosis in the range age 22-35, a pregnant female in range age 17-37, female menopause range age 45-75, and healthy females in range age 19-65 as the control group. The biochemical variables such as level of Cathepsin K Cath-k concentration, Estradiol E2 concentration, vitamin D Vit -D, and parathyroid hormone PTH concentration in women with osteoporosis, menopause, pregnant and healthy women were evaluated. In addition, the hematological variables: red blood cells RBCs, hemoglobin Hb, hematocrit HCT, number of platelets PLT, and number of white blood cells WBCs were evaluated in different study groups. Also, the concentration of phosphate P and Body Mass Index BMI was estimated. In the end, the correlation test with each variable in different group studies was calculated by the STATISTICA program. The obtained results showed that there was a significant increase in the numbers of WBCs, the concentration of Cath-k, PTH, and BMI for the study groups compared to the control group, as well as a significant decrease in the concentration of P and Vit -D for the study groups compared to the control group. There is a significant increase in the E2 hormone in the group of pregnant women and a significant decrease in women with osteoporosis who are in menopause compared to the control group, as well as the presence of a significant decrease in RBCs, and Hb in the group of pregnant women compared to the control group. There is a significant increase in the numbers of PLT in the group of women with osteoporosis and women in menopause compared to the control group, as it is concluded from the current study that there is a close correlation between some different variables, including a good correlation between BMI and PLT was found to be 0.83. This may confirm that BMI is associated with increased cardiovascular morbidity and mortality through various molecular mechanisms possibly linking metabolic syndrome to hemostatic and vascular abnormalities in addition, a good correlation was observed between PTH and Cat-k 0.89, which indicated there is a relation between these two parameters.

 In this study, the biochemical and hematological variables in 180 patients women between 17 and 75 years old were hospitalized at Al-Sadr Teaching Hospital in Najaf Iraq between April and July 2023. The patients were devised in 4 different group studies with 180 patients in each group consisting of 45 women: female with osteoporosis in the range age 22-35, a pregnant female in range age 17-37, female menopause range age 45-75, and healthy females in range age 19-65 as the control group. The biochemical variables such as level of Cathepsin K Cath-k concentration, Estradiol E2 concentration, vitamin D Vit -D, and parathyroid hormone PTH concentration in women with osteoporosis, menopause, pregnant and healthy women were evaluated. In addition, the hematological variables: red blood cells RBCs, hemoglobin Hb, hematocrit HCT, number of platelets PLT, and number of white blood cells WBCs were evaluated in different study groups. Also, the concentration of phosphate P and Body Mass Index BMI was estimated. In the end, the correlation test with each variable in different group studies was calculated by the STATISTICA program. The obtained results showed that there was a significant increase in the numbers of WBCs, the concentration of Cath-k, PTH, and BMI for the study groups compared to the control group, as well as a significant decrease in the concentration of P and Vit -D for the study groups compared to the control group. There is a significant increase in the E2 hormone in the group of pregnant women and a significant decrease in women with osteoporosis who are in menopause compared to the control group, as well as the presence of a significant decrease in RBCs, and Hb in the group of pregnant women compared to the control group. There is a significant increase in the numbers of PLT in the group of women with osteoporosis and women in menopause compared to the control group, as it is concluded from the current study that there is a close correlation between some different variables, including a good correlation between BMI and PLT was found to be 0.83. This may confirm that BMI is associated with increased cardiovascular morbidity and mortality through various molecular mechanisms possibly linking metabolic syndrome to hemostatic and vascular abnormalities in addition, a good correlation was observed between PTH and Cat-k 0.89, which indicated there is a relation between these two parameters.

 In this study, the biochemical and hematological variables in 180 patients women between 17 and 75 years old were hospitalized at Al-Sadr Teaching Hospital in Najaf Iraq between April and July 2023. The patients were devised in 4 different group studies with 180 patients in each group consisting of 45 women: female with osteoporosis in the range age 22-35, a pregnant female in range age 17-37, female menopause range age 45-75, and healthy females in range age 19-65 as the control group. The biochemical variables such as level of Cathepsin K Cath-k concentration, Estradiol E2 concentration, vitamin D Vit -D, and parathyroid hormone PTH concentration in women with osteoporosis, menopause, pregnant and healthy women were evaluated. In addition, the hematological variables: red blood cells RBCs, hemoglobin Hb, hematocrit HCT, number of platelets PLT, and number of white blood cells WBCs were evaluated in different study groups. Also, the concentration of phosphate P and Body Mass Index BMI was estimated. In the end, the correlation test with each variable in different group studies was calculated by the STATISTICA program. The obtained results showed that there was a significant increase in the numbers of WBCs, the concentration of Cath-k, PTH, and BMI for the study groups compared to the control group, as well as a significant decrease in the concentration of P and Vit -D for the study groups compared to the control group. There is a significant increase in the E2 hormone in the group of pregnant women and a significant decrease in women with osteoporosis who are in menopause compared to the control group, as well as the presence of a significant decrease in RBCs, and Hb in the group of pregnant women compared to the control group. There is a significant increase in the numbers of PLT in the group of women with osteoporosis and women in menopause compared to the control group, as it is concluded from the current study that there is a close correlation between some different variables, including a good correlation between BMI and PLT was found to be 0.83. This may confirm that BMI is associated with increased cardiovascular morbidity and mortality through various molecular mechanisms possibly linking metabolic syndrome to hemostatic and vascular abnormalities in addition, a good correlation was observed between PTH and Cat-k 0.89, which indicated there is a relation between these two parameters.

Makale detayları

The relationship of cathepsin-k level with some biochemical and hematogical variables in women with osteoporosis, pregnant and menopausal

Yazarlar:

Ali Al-khafaji | Rima Nour Elhouda Tiri | Ayşenur Aygün | Ebru Halvacı | Fatih Şen

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Analytical Biochemistry | Medical Biochemistry - Nucleic Acids | Plant Protection (Other)

Dergi:

Journal of Scientific Reports-B Issue 011, pp.35-53

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326280

pISSN:

2717-8625

Cat-k

Vit-D

Osteoporosis

Correlation

STATISTICA program

Hematological variables

Biochemical variables

Sayı

Makale detayları

Yazarlar: Ali Al-khafaji | Rima Nour Elhouda Tiri | Ayşenur Aygün | Ebru Halvacı | Fatih Şen

Yayıncı: Kütahya Dumlupinar University

Ana Başlıklar: Analytical Biochemistry | Medical Biochemistry - Nucleic Acids | Plant Protection (Other)

Dergi: Journal of Scientific Reports-B Issue 011, pp.35-53

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326280

pISSN: 2717-8625

Sayı

Yazarlar:

Ali Al-khafaji | Rima Nour Elhouda Tiri | Ayşenur Aygün | Ebru Halvacı | Fatih Şen

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Analytical Biochemistry | Medical Biochemistry - Nucleic Acids | Plant Protection (Other)

Dergi:

Journal of Scientific Reports-B Issue 011, pp.35-53

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326280

pISSN:

2717-8625