AN UPDATE OF CLINICAL TRIALS LANDSCAPE IN TÜRKİYE

Ayşegül Özsoy; Selçuk Şen

Makale detayları

AN UPDATE OF CLINICAL TRIALS LANDSCAPE IN TÜRKİYE

Yazarlar:

Ayşegül Özsoy | Selçuk Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.99-106

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330845

pISSN:

2651-4060

Anahtar kelimeler:

Özet:

 Objective: Clinical research is essential to enhance scientific knowledge and provide better patient outcomes. This work evaluated clinical trials in Türkiye between 2019-2023 and compared them with previous research. Material and Method: Clinical trials in Türkiye registered in the ClinicalTrials.gov database between 01.01.2019 and 30.09.2023 were examined and evaluated. Trials were filtered by study type, study phase, recruitment status, funder type, location, condition, or disease. Comparative analyses were executed for different cities and countries. Results: The total number of registered clinical trials in Türkiye was 12,563. The number of trials registered between 2019 and 2023 was 8,851. Of these, 68.21 were interventional and 9.3 were industrysponsored. The majority of trials 61.13 were completed, while 18.78 were still recruiting patients. Leading cities in Türkiye were Istanbul and Ankara with the highest trial numbers. Despite a remarkable increase in the total number of clinical trials in Türkiye, no considerable change was detected in the number of industry-sponsored trials. The majority of trials with unknown status 85 were non-industry-sponsored in all countries in the comparative analysis. The highest numbers of trials were found in respiratory, painpain management and oncology in Türkiye among the evaluated fields including cardiovascular disease, genetic disorders, diabetes, and obesity. Conclusion: The total number of clinical trials in Türkiye showed a considerable increase when compared with developed countries including Germany, France, and the United Kingdom, however, the reasons behind the lower number and stability in the yearly increase rate of industrysponsored trials should be revisited by all stakeholders.

 Objective: Clinical research is essential to enhance scientific knowledge and provide better patient outcomes. This work evaluated clinical trials in Türkiye between 2019-2023 and compared them with previous research. Material and Method: Clinical trials in Türkiye registered in the ClinicalTrials.gov database between 01.01.2019 and 30.09.2023 were examined and evaluated. Trials were filtered by study type, study phase, recruitment status, funder type, location, condition, or disease. Comparative analyses were executed for different cities and countries. Results: The total number of registered clinical trials in Türkiye was 12,563. The number of trials registered between 2019 and 2023 was 8,851. Of these, 68.21 were interventional and 9.3 were industrysponsored. The majority of trials 61.13 were completed, while 18.78 were still recruiting patients. Leading cities in Türkiye were Istanbul and Ankara with the highest trial numbers. Despite a remarkable increase in the total number of clinical trials in Türkiye, no considerable change was detected in the number of industry-sponsored trials. The majority of trials with unknown status 85 were non-industry-sponsored in all countries in the comparative analysis. The highest numbers of trials were found in respiratory, painpain management and oncology in Türkiye among the evaluated fields including cardiovascular disease, genetic disorders, diabetes, and obesity. Conclusion: The total number of clinical trials in Türkiye showed a considerable increase when compared with developed countries including Germany, France, and the United Kingdom, however, the reasons behind the lower number and stability in the yearly increase rate of industrysponsored trials should be revisited by all stakeholders.

 Objective: Clinical research is essential to enhance scientific knowledge and provide better patient outcomes. This work evaluated clinical trials in Türkiye between 2019-2023 and compared them with previous research. Material and Method: Clinical trials in Türkiye registered in the ClinicalTrials.gov database between 01.01.2019 and 30.09.2023 were examined and evaluated. Trials were filtered by study type, study phase, recruitment status, funder type, location, condition, or disease. Comparative analyses were executed for different cities and countries. Results: The total number of registered clinical trials in Türkiye was 12,563. The number of trials registered between 2019 and 2023 was 8,851. Of these, 68.21 were interventional and 9.3 were industrysponsored. The majority of trials 61.13 were completed, while 18.78 were still recruiting patients. Leading cities in Türkiye were Istanbul and Ankara with the highest trial numbers. Despite a remarkable increase in the total number of clinical trials in Türkiye, no considerable change was detected in the number of industry-sponsored trials. The majority of trials with unknown status 85 were non-industry-sponsored in all countries in the comparative analysis. The highest numbers of trials were found in respiratory, painpain management and oncology in Türkiye among the evaluated fields including cardiovascular disease, genetic disorders, diabetes, and obesity. Conclusion: The total number of clinical trials in Türkiye showed a considerable increase when compared with developed countries including Germany, France, and the United Kingdom, however, the reasons behind the lower number and stability in the yearly increase rate of industrysponsored trials should be revisited by all stakeholders.

 Amaç: Klinik araştırmalar bilimsel bilgiyi geliştirmek ve hastalar için daha iyi sonuçlar elde etmek adına gerekli araçlardır. Bu çalışma Türkiyede 2019-2023 yılları arasında yapılmış olan klinik çalışmaları değerlendirmeyi ve önceki analizle karşılaştırma yapmayı amaçlamaktadır . Gereç ve Yöntem: Türkiyede yapılmış olan klinik araştırmaları değerlendirmek için ClinicalTrials.gov veri tabanına 01.01.2019 ve 30.09.2023 tarihleri arasında kaydedilen klinik araştırmalar incelenmiştir. Araştırmalar çalışma türü, çalışma fazı, çalışmanın durumu, destekleyici türü, lokasyon, hastalık durumuna göre filtrelenmiştir. Türkiyedeki farklı şehirler ve farklı ülkeler için karşılaştırmalı analiz yapılmıştır. Bulgular: ClinicalTrials.gov veritabanında Türkiyede kayıtlı olan klinik araştırma toplam sayısı 12563tür. 2019-2023 yılları arasında kaydedilmiş olan çalışma sayısı ise 8851dir. Bu çalışmaların 68,21si girişimsel, 9,3ü endüstri tarafından desteklenen çalışmalardır. Çalışmaların çoğunluğu olan 61,13ü tamamlanmıştır, 18,78i ise hala hasta alımı yapmaktadır. En fazla klinik çalışma kayıtlı olan iller İstanbul ve Ankaradır. Türkiyede toplam klinik çalışma sayısında belirgin bir artış olmasına rağmen endüstri tarafından desteklenen çalışma sayısında anlamlı bir değişiklik saptanmamıştır. Karşılaştırmalı analize dahil edilen ülkelerin tamamında durumu bilinmeyen çalışmaların çoğunluğu 85 endüstri tarafından desteklenmeyen çalışmalardır. Kardiyovasküler hastalık, genetik hastalıklar, diyabet ve obezitenin de dahil olduğu farklı tıbbi alanlar değerlendirildiğinde Türkiyede klinik çalışma sayısının en fazla olduğu alanlar solunum hastalıkları, ağrıağrı yönetimi ve onkoloji olmuştur. Sonuç: Türkiyede klinik çalışma sayısı artmış ve Almanya, Fransa, Birleşik Krallık gibi gelişmiş ülkelerle karşılaştırıldığında benzer bir sayıya ulaşmıştır. Bununla birlikte, endüstri tarafından desteklenen çalışmaların sayısının daha düşük olması ve yıllık artışlarının sabit olmasının nedenleri tüm paydaşlar tarafından tekrar gözden geçirilmelidir.

Makale detayları

AN UPDATE OF CLINICAL TRIALS LANDSCAPE IN TÜRKİYE

Yazarlar:

Ayşegül Özsoy | Selçuk Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.99-106

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330845

pISSN:

2651-4060

Clinical trials

Türkiye

researchKlinik araştırmalar

Türkiye

araştırma

Sayı

Makale detayları

AN UPDATE OF CLINICAL TRIALS LANDSCAPE IN TÜRKİYE

Yazarlar: Ayşegül Özsoy | Selçuk Şen

Yayıncı: Istanbul University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.99-106

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330845

pISSN: 2651-4060

Clinical trials

Türkiye

researchKlinik araştırmalar

Türkiye

araştırma

Sayı

Yazarlar:

Ayşegül Özsoy | Selçuk Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Journal of Advanced Research in Health Sciences Vol.7 Issue 2, pp.99-106

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330845

pISSN:

2651-4060