Investigation and Quantification of Electrochemical Properties of the  Anti-Cancer Drug Vinblastine on the Pencil Graphite Electrode Surface

Günay Önal

Makale detayları

Investigation and Quantification of Electrochemical Properties of the Anti-Cancer Drug Vinblastine on the Pencil Graphite Electrode Surface

Yazarlar:

Günay Önal

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Elektrokimya

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.344-354

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001288781

pISSN:

2149-3367

Anahtar kelimeler:

Özet:

 Vinblastine VNB is an antineoplastic drug used in cancer chemotherapy. In this presented study, the electrochemical properties of VNB were investigated in a wide pH range with disposable pencil graphite PG electrode and different supporting electrolytes BrittonRobinson 0.04 M BR, pH 2.0-12.0, phosphate 0.04 M PBS, pH. 2.0, 3.0, 4.0, 7.4 and acetate 0.04 M ABS, pH 4.8 were studied by cyclic voltammetry CV and Square Wave Voltammetry SWV techniques. VNB gave an irreversible oxidation peak with CV in BR pH 2.0 at 0.993 V potential and 3.844 µA current. With the SWV technique, the anodic current signal showed a linear correlation with the concentration between 11 nM and 495 nM in BR pH 2.0  Ip µA  0.0087 C nM - 0.3448 r  0.993, n  12  . At a concentration level of 11 nM, a limit of detection LOD of 2.4 nM and a relative standard deviation of 2.93 were calculated. The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.

 Vinblastine VNB is an antineoplastic drug used in cancer chemotherapy. In this presented study, the electrochemical properties of VNB were investigated in a wide pH range with disposable pencil graphite PG electrode and different supporting electrolytes BrittonRobinson 0.04 M BR, pH 2.0-12.0, phosphate 0.04 M PBS, pH. 2.0, 3.0, 4.0, 7.4 and acetate 0.04 M ABS, pH 4.8 were studied by cyclic voltammetry CV and Square Wave Voltammetry SWV techniques. VNB gave an irreversible oxidation peak with CV in BR pH 2.0 at 0.993 V potential and 3.844 µA current. With the SWV technique, the anodic current signal showed a linear correlation with the concentration between 11 nM and 495 nM in BR pH 2.0  Ip µA  0.0087 C nM - 0.3448 r  0.993, n  12  . At a concentration level of 11 nM, a limit of detection LOD of 2.4 nM and a relative standard deviation of 2.93 were calculated. The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.

 Vinblastine VNB is an antineoplastic drug used in cancer chemotherapy. In this presented study, the electrochemical properties of VNB were investigated in a wide pH range with disposable pencil graphite PG electrode and different supporting electrolytes BrittonRobinson 0.04 M BR, pH 2.0-12.0, phosphate 0.04 M PBS, pH. 2.0, 3.0, 4.0, 7.4 and acetate 0.04 M ABS, pH 4.8 were studied by cyclic voltammetry CV and Square Wave Voltammetry SWV techniques. VNB gave an irreversible oxidation peak with CV in BR pH 2.0 at 0.993 V potential and 3.844 µA current. With the SWV technique, the anodic current signal showed a linear correlation with the concentration between 11 nM and 495 nM in BR pH 2.0  Ip µA  0.0087 C nM - 0.3448 r  0.993, n  12  . At a concentration level of 11 nM, a limit of detection LOD of 2.4 nM and a relative standard deviation of 2.93 were calculated. The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.

 Kanser kemoterapisinde kullanılan vinblastin VNB antineoplastik bir ilaçtır. Sunulan bu çalışmada, VNBnin elektrokimyasal özellikleri tek kullanımlık kalem grafit PG elektrot ile geniş bir pH aralığında ve farklı destek elektrolitler BrittonRobinson 0.04 M BR, pH 2.0-12.0, fosfat 0.04 M PBS, pH 2.0, 3.0, 4.0, 7.4 ve asetat  0.04 M ABS, pH 4.8 içinde döngüsel voltametri CV ve Kare Dalga Voltametri SWV teknikleriyle incelenmiştir. VNB, 0.993 V gerilim ve 3.844 µA akım değerinde BR pH 2.0 içinde CV ile tersinmez bir yükseltgenme piki vermiştir. SWV tekniği ile anodik akım sinyali, BR pH 2.0 içerisinde 11 nM ile 495 nM arasında derişim ile doğrusal bir korelasyon gösterdi Ip µA  0.0087 C nM - 0.3448 r  0.993, n  12 . 11 nM derişim seviyesinde, 2.4 nM gözlenebilme sınırı LOD ve  2.93 göreli standart sapma hesaplandı. Önerilen yöntemin analitik uygulaması ilaç ve idrar örneklerinde pratik edilmiş ve geri kazanımlarla gösterilmiştir.

Makale detayları

Investigation and Quantification of Electrochemical Properties of the Anti-Cancer Drug Vinblastine on the Pencil Graphite Electrode Surface

Yazarlar:

Günay Önal

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Elektrokimya

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.344-354

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001288781

pISSN:

2149-3367

Vinblastine

Pencil Graphite Electrode

Voltammetry

Vial

urineVinblastin;

kalem grafit elektrot

voltametri

Flakon

idrar

Sayı

Makale detayları

Yazarlar: Günay Önal

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: Elektrokimya

Dergi: Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.344-354

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001288781

pISSN: 2149-3367

Sayı

Yazarlar:

Günay Önal

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Elektrokimya

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.344-354

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001288781

pISSN:

2149-3367