INTERRELATIONS BETWEEN SERUM N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE (NT-PROBNP) LEVELS AND EARLY CARDIOVASCULAR RISK FACTORS AND ECHOCARDIOGRAPHIC PARAMETERS IN OBESE ADOLESCENTS

Mehmet BOYRAZ; Atilla ÇİFCİ

Makale detayları

INTERRELATIONS BETWEEN SERUM N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE (NT-PROBNP) LEVELS AND EARLY CARDIOVASCULAR RISK FACTORS AND ECHOCARDIOGRAPHIC PARAMETERS IN OBESE ADOLESCENTS

Yazarlar:

Mehmet BOYRAZ | Atilla ÇİFCİ

Yayıncı:

Ankara EAH

Dergi:

Medical Journal of Ankara Training and Research Hospital 2019 Vol.52 Issue 1, pp.20-27

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000672454

Sıklık:

Üç Yıllık

pISSN:

1304-6187

Özet:

 


Purpose:
This study aimed to evaluate the associations between the N-terminal pro-B-type
natriuretic peptide (NT-proBNP) levels and the metabolic, echocardiographic
parameters, carotid intima-media thickness (IMT) and epicardial adipose tissue
thickness (EATT) in adolescent obesity. 


Material
and Method: The study participants consisted of 138 obese
adolescents in the study group and 63 non-obese adolescents as control
subjects. All the subjects underwent transthoracic echocardiographic
examination for determination of left ventricular (LV) systolic function and
mass index, myocardial tissue rates, and myocardial performance index (MPI).
Epicardial adipose tissue thickness and carotid IMT were also measured during
echocardiography. Serum NT-proBNP levels were measured at the time of the
evaluation. 


Results:
The NT-proBNP values averaged 67.20 ± 64.40 pg/ml in mildly-moderately obese,
76.00 ± 49.70 pg/ml in the severely obese group and 44.30 ± 23.30 pg/ml in the
control group (p = 0.007, p = 0.002, respectively). The average carotid IMT was
0.91 ± 0.23 and 0.88 ± 0.18 mm in the obesity groups and 0.52 ± 0.08 mm in the
control group (p= 0.0001), but differences were not observed between obesity
groups and the EATT which averaged 7.38 ± 1.76 and 7.42 ± 1.55 mm in the
obesity groups and 4.28 ± 0.79 mm in the control group (p = 0.0001). The
NT-proBNP levels showed statistically significant positive correlations with
left ventricular systolic and diastolic functions, carotid IMT, or EATT values,
especially in severe obesity.









Conclusion:
The study showed higher measurements of serum NT-proBNP levels in
mildly-moderately and severely obese adolescents than control and NT-proBNP
might be a useful marker for predicting atherosclerosis and cardiac dysfunction
in the obese adolescent. 


.

 




 



 






 

SONUÇLAR:


Çalışmamızda,
hafif-orta ve şiddetli obez ergenlerde serum
NT- proBNP düzeylerinin kontrol grubuna göre daha yüksek olduğunu ve
NT- proBNP'nin obez ergenlerde ateroskleroz ve kardiyak
disfonksiyonu öngörmede yararlı bir belirteç olabileceğini gösterdi. 


.

Makale detayları

INTERRELATIONS BETWEEN SERUM N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE (NT-PROBNP) LEVELS AND EARLY CARDIOVASCULAR RISK FACTORS AND ECHOCARDIOGRAPHIC PARAMETERS IN OBESE ADOLESCENTS

Yazarlar: Mehmet BOYRAZ | Atilla ÇİFCİ

Yayıncı: Ankara EAH

Dergi: Medical Journal of Ankara Training and Research Hospital 2019 Vol.52 Issue 1, pp.20-27

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000672454

Sıklık: Üç Yıllık

pISSN: 1304-6187

Sayı

Yazarlar:

Mehmet BOYRAZ | Atilla ÇİFCİ

Yayıncı:

Ankara EAH

Dergi:

Medical Journal of Ankara Training and Research Hospital 2019 Vol.52 Issue 1, pp.20-27

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000672454

Sıklık:

Üç Yıllık

pISSN:

1304-6187