Multidrug-resistant bacteria in hospitalized patients with cystic fibrosis: a retrospective cross-sectional study

Serkan Atıcı; Emine Atağ; Bülent Karadağ; Ahmet Soysal

Makale detayları

Multidrug-resistant bacteria in hospitalized patients with cystic fibrosis: a retrospective cross-sectional study

Yazarlar:

Serkan Atıcı | Emine Atağ | Bülent Karadağ | Ahmet Soysal

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Bulaşıcı Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 5, pp.630-634

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358260

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aims: The emergence of multidrug-resistant MDR bacterial pathogens has become a critical clinical challenge in cystic fibrosis CF patients. This study aimed to characterize MDR bacterial isolates in hospitalized CF patients experiencing pulmonary exacerbations. Methods: We defined MDR as resistance to three or more antimicrobial classes. The study included 45 acute exacerbation episodes with confirmed MDR bacterial growth among 32 CF pediatric patients hospitalized at Marmara University Pendik Training and Research Hospital. Results: Among 32 CF patients mean age: 114.762.1 months; 68.8 female, we analyzed 45 exacerbation episodes. The most common clinical manifestations were increased sputum production 73.3, cough 60, and fever 31. Pseudomonas aeruginosa colonization was previously documented in 55.6 of cases. Respiratory cultures revealed MDR bacteria in all patients, with P. aeruginosa 53.4, Staphylococcus aureus 17.8, and Acinetobacter baumannii 4.4 being the predominant isolates. Combination antibiotic therapy was required in 82 of cases 3745, while only 18 845 received monotherapy. The mean hospitalization duration was 17.38.4 days, with an overall mortality rate of 6.2 n2. Conclusion: MDR infections in CF patients demand a multifaceted approach. Rotating antibiotic regimens and avoiding carbapenem overuse may reduce resistance. Tailored antibiotic regimens and antimicrobial stewardship programme, robust infection controls such as enhanced screening for MDR colonization and isolation protocols are needed to curb transmission, and sustained research into emerging pathogens. Our data reinforce the urgent need for CF-specific antimicrobial protocols in Turkiye and similar countries.

 Aims: The emergence of multidrug-resistant MDR bacterial pathogens has become a critical clinical challenge in cystic fibrosis CF patients. This study aimed to characterize MDR bacterial isolates in hospitalized CF patients experiencing pulmonary exacerbations. Methods: We defined MDR as resistance to three or more antimicrobial classes. The study included 45 acute exacerbation episodes with confirmed MDR bacterial growth among 32 CF pediatric patients hospitalized at Marmara University Pendik Training and Research Hospital. Results: Among 32 CF patients mean age: 114.762.1 months; 68.8 female, we analyzed 45 exacerbation episodes. The most common clinical manifestations were increased sputum production 73.3, cough 60, and fever 31. Pseudomonas aeruginosa colonization was previously documented in 55.6 of cases. Respiratory cultures revealed MDR bacteria in all patients, with P. aeruginosa 53.4, Staphylococcus aureus 17.8, and Acinetobacter baumannii 4.4 being the predominant isolates. Combination antibiotic therapy was required in 82 of cases 3745, while only 18 845 received monotherapy. The mean hospitalization duration was 17.38.4 days, with an overall mortality rate of 6.2 n2. Conclusion: MDR infections in CF patients demand a multifaceted approach. Rotating antibiotic regimens and avoiding carbapenem overuse may reduce resistance. Tailored antibiotic regimens and antimicrobial stewardship programme, robust infection controls such as enhanced screening for MDR colonization and isolation protocols are needed to curb transmission, and sustained research into emerging pathogens. Our data reinforce the urgent need for CF-specific antimicrobial protocols in Turkiye and similar countries.

 Aims: The emergence of multidrug-resistant MDR bacterial pathogens has become a critical clinical challenge in cystic fibrosis CF patients. This study aimed to characterize MDR bacterial isolates in hospitalized CF patients experiencing pulmonary exacerbations. Methods: We defined MDR as resistance to three or more antimicrobial classes. The study included 45 acute exacerbation episodes with confirmed MDR bacterial growth among 32 CF pediatric patients hospitalized at Marmara University Pendik Training and Research Hospital. Results: Among 32 CF patients mean age: 114.762.1 months; 68.8 female, we analyzed 45 exacerbation episodes. The most common clinical manifestations were increased sputum production 73.3, cough 60, and fever 31. Pseudomonas aeruginosa colonization was previously documented in 55.6 of cases. Respiratory cultures revealed MDR bacteria in all patients, with P. aeruginosa 53.4, Staphylococcus aureus 17.8, and Acinetobacter baumannii 4.4 being the predominant isolates. Combination antibiotic therapy was required in 82 of cases 3745, while only 18 845 received monotherapy. The mean hospitalization duration was 17.38.4 days, with an overall mortality rate of 6.2 n2. Conclusion: MDR infections in CF patients demand a multifaceted approach. Rotating antibiotic regimens and avoiding carbapenem overuse may reduce resistance. Tailored antibiotic regimens and antimicrobial stewardship programme, robust infection controls such as enhanced screening for MDR colonization and isolation protocols are needed to curb transmission, and sustained research into emerging pathogens. Our data reinforce the urgent need for CF-specific antimicrobial protocols in Turkiye and similar countries.

 Amaç: Çoklu ilaca dirençli ÇİD bakteriyel patojenlerin ortaya çıkışı, kistik fibroz KF hastalarında kritik bir klinik sorun haline gelmiştir. Bu çalışma, hastanede yatan ve alevlenmeler yaşayan KF hastalarında ÇİD bakteri izolatlarını karakterize etmeyi amaçlamıştır. Yöntemler: ÇİDyi, üç veya daha fazla antimikrobiyal sınıfa direnç olarak tanımladık. Çalışmaya, Marmara Üniversitesi Pedik Eğitim ve Araştırma Hastanesinde yatan 32 KF hastası arasında doğrulanmış ÇİD bakteri üremesi olan 45 akut alevlenme atağı dahil edildi. Sonuçlar: 32 KF hastası ortalama yaş: 114,7  62,1 ay; 68,8i kadın arasında, 45 alevlenme atağı tesbit edildi. En sık görülen klinik bulgular balgamda artış 73,3, öksürük 60 ve ateş 31 idi. Pseudomonas aeruginosa kolonizasyonu vakaların 55,6sında mevcuttu. Tüm hastaların solunum yolu kültürlerinde ÇİD bakteri üremesi vardı. P. aeruginosa 53,4, Staphylococcus aureus 17,8 ve Acinetobacter baumannii 4,4 baskın izolatlardı. Vakaların 82sinde 3745 kombine antibiyotik tedavisi gerekirken, sadece 18ine 845 monoterapi uygulandı. Ortalama hastanede kalış süresi 17,38,4 gündü ve genel mortalite oranı 6,2ydi n2. Sonuçlar: Kistik fibrozis hastalarında ÇİD enfeksiyonların takibi ve tedavisi multidisipliner yaklaşım gerektirir. Antibiyotik rejimlerinin dönüşümlü olarak uygulanması ve karbapenem aşırı kullanımından kaçınılması direnci azaltabilir. Bulaşmayı azaltmak için hasta özelinde antibiyotik rejimleri ve antimikrobiyal yönetim programları gereklidir. ÇİD kolonizasyonu için gelişmiş tarama ve izolasyon protokolleri gibi güçlü enfeksiyon kontrolleri ve yeni ortaya çıkan patojenler üzerinde sürekli araştırmalara ihtiyaç vardır. Verilerimiz, Türkiye ve benzeri ülkelerde KFye özgü antimikrobiyal tedavi protokollerine ihtiyaç olduğunu desteklemektedir.

Makale detayları

Multidrug-resistant bacteria in hospitalized patients with cystic fibrosis: a retrospective cross-sectional study

Yazarlar:

Serkan Atıcı | Emine Atağ | Bülent Karadağ | Ahmet Soysal

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Bulaşıcı Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 5, pp.630-634

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358260

pISSN:

2718-0115

Cystic fibrosis

multidrug-resistant

hospitalized patientsKistik fibroz

çoklu ilaç direnci

hastanede yatan hastalar

Sayı

Makale detayları

Multidrug-resistant bacteria in hospitalized patients with cystic fibrosis: a retrospective cross-sectional study

Yazarlar: Serkan Atıcı | Emine Atağ | Bülent Karadağ | Ahmet Soysal

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Bebek ve Çocuk Sağlığı | Çocuk Bulaşıcı Hastalıkları

Dergi: Anatolian Current Medical Journal Vol.7 Issue 5, pp.630-634

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358260

pISSN: 2718-0115

Cystic fibrosis

multidrug-resistant

hospitalized patientsKistik fibroz

çoklu ilaç direnci

hastanede yatan hastalar

Sayı

Yazarlar:

Serkan Atıcı | Emine Atağ | Bülent Karadağ | Ahmet Soysal

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Bulaşıcı Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 5, pp.630-634

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358260

pISSN:

2718-0115