Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic  hepatitis and liver cirrhosis

Ramazan DERTLİ; Muharrem KESKİN; Murat BIYIK; Hüseyin ATASEVEN; Hakkı POLAT; Ali DEMİR; Pembe OLTULU; Salim NEŞELOĞLU; Özcan EREL; Mehmet ASIL

Makale detayları

Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis

Yazarlar:

Ramazan DERTLİ | Muharrem KESKİN | Murat BIYIK | Hüseyin ATASEVEN | Hakkı POLAT | Ali DEMİR | Pembe OLTULU | Salim NEŞELOĞLU | Özcan EREL | Mehmet ASIL

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.985-992

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750564

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 


 
                         Background/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigate
dynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.
Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated
liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serum
disulfide concentrations were measured using an automated method.
Results: Mean serum total thiol concentrations in the control, CHB, and cirrhosis groups were 481.64 ± 37.87 µmol/L, 438.50 ± 71.35
µmol/L, and 358.07 ± 80.47 µmol/L, respectively (P < 0.001), and mean serum native thiol concentrations in the control, CHB, and
cirrhosis groups were 452.92 ± 36.43 µmol/L, 400.16 ± 65.92 µmol/L, and 328.15 ± 74.91 µmol/L, respectively (P < 0.001). Mean serum
disulfide concentrations in the control, CHB, and cirrhosis groups were 14.38 ± 3.38 µmol/L, 19.19 ± 6.16 µmol/L, and 14.98 ± 5.53
µmol/L, respectively (P < 0.001). There was a progressive decrease in both mean serum native and total thiol concentrations parallel to
the liver fibrosis stage.
Conclusion: : Thiol-disulfide homeostasis is disturbed in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.
                    

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Makale detayları

Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis

Yazarlar: Ramazan DERTLİ | Muharrem KESKİN | Murat BIYIK | Hüseyin ATASEVEN | Hakkı POLAT | Ali DEMİR | Pembe OLTULU | Salim NEŞELOĞLU | Özcan EREL | Mehmet ASIL

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.985-992

Belge Tipi: Makale

Yayın Tarihi: 10/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750564

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Ramazan DERTLİ | Muharrem KESKİN | Murat BIYIK | Hüseyin ATASEVEN | Hakkı POLAT | Ali DEMİR | Pembe OLTULU | Salim NEŞELOĞLU | Özcan EREL | Mehmet ASIL

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.985-992

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750564

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144