Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Sj Hosseinimehr

Makale detayları

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Yazarlar:

Sj Hosseinimehr

Yayıncı:

Marmara University

Ana Başlıklar:

Radiopharmacy

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.307-313

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346184

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation IR still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles CNPs on non-small lung cancer A-549 cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

 Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation IR still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles CNPs on non-small lung cancer A-549 cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

 Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation IR still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles CNPs on non-small lung cancer A-549 cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

 Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation IR still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles CNPs on non-small lung cancer A-549 cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

Makale detayları

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Yazarlar:

Sj Hosseinimehr

Yayıncı:

Marmara University

Ana Başlıklar:

Radiopharmacy

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.307-313

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346184

pISSN:

2630-6344

Cerium oxide nanoparticle

nanoceria

radiosensitizing

apoptosis

ionizing radiation

radiosensitizer

Sayı

Makale detayları

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Yazarlar: Sj Hosseinimehr

Yayıncı: Marmara University

Ana Başlıklar: Radiopharmacy

Dergi: Journal of Research in Pharmacy Vol.22 Issue 2, pp.307-313

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346184

pISSN: 2630-6344

Cerium oxide nanoparticle

nanoceria

radiosensitizing

apoptosis

ionizing radiation

radiosensitizer

Sayı

Yazarlar:

Sj Hosseinimehr

Yayıncı:

Marmara University

Ana Başlıklar:

Radiopharmacy

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.307-313

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346184

pISSN:

2630-6344