Relationship between Plasma Levels of Homocysteine and Pro-Inflammatory  Cytokines in Patients with Rheumatoid Arthritis

Ayşe Balkarli

doi:https://doi.org/10.5799/ahinjs.01.2016.02.0590

Makale detayları

Relationship between Plasma Levels of Homocysteine and Pro-Inflammatory Cytokines in Patients with Rheumatoid Arthritis

Yazarlar:

Ayşe Balkarli

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.163-167

Belge Tipi:

Makale

Yayın Tarihi:

6/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000833213

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/ahinjs.01.2016.02.0590

Özet:

 


	Objective: The aim of the study was to investigate 
levels of homocysteine (Hcy), folate, vitamin B12, interleukin-6 (IL-6) 
and Tumor necrosis factor-alpha (TNF-α) and to assess relationship 
between Hcy levels and inflammatory mediators including IL-6 and TNF-α 
in untreated patients with rheumatoid arthritis (RA).

	Methods: The study included 55 women including 30 
newly diagnosed and untreated female RA patients and 25 age-matched 
healthy individuals as controls.

	Results: Erythrocyte sedimentation rate (ESH), 
C-reactive protein (CRP), IL-6 and TNF-α levels were significantly 
higher in RA patients than controls (p0.05). There 
were no significant correlations between Hcy levels and acute phase 
reactants or inflammatory mediators (p>0.05).

	Conclusion: Both mediators such as IL-6 and TNF-α and 
hyper-homocysteinemia are associated with atherosclerotic cardiovascular
 diseases. There was no significant correlation between Hcy levels and 
inflammatory mediators, although levels of these molecules were elevated
 in RA. Both inflammatory mediators and Hcy may cause an increase in 
atherosclerotic cardiovascular disorders through diverse pathways. J Clin Exp Invest 2016; 7 (2): 163-167


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Makale detayları

Relationship between Plasma Levels of Homocysteine and Pro-Inflammatory Cytokines in Patients with Rheumatoid Arthritis

Yazarlar: Ayşe Balkarli

Yayıncı: Sağlık Araştırmaları Derneği

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.163-167

Belge Tipi: Makale

Yayın Tarihi: 6/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000833213

Sıklık: Üç Aylık

eISSN: 1309-6621

pISSN: 1309-8578

DOI: https://doi.org/10.5799/ahinjs.01.2016.02.0590

Sayı

Yazarlar:

Ayşe Balkarli

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.163-167

Belge Tipi:

Makale

Yayın Tarihi:

6/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000833213

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/ahinjs.01.2016.02.0590