Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Büşra Ertaş; Rezzan Gülhan; Refiye Yanardağ; Özlem Saçan; Göksel Şener

Makale detayları

Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Yazarlar:

Büşra Ertaş | Rezzan Gülhan | Refiye Yanardağ | Özlem Saçan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.589-599

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346225

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Alzheimers disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla BV has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anticholinesterase and anti- inflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular ICV administration of streptozotocin STZ. STZ was administered bilaterally at a dose of 3 mgkg via ICV to rats, and BV treatment at a dose of 2 gkg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF- and IL-1 levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.

 Alzheimers disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla BV has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anticholinesterase and anti- inflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular ICV administration of streptozotocin STZ. STZ was administered bilaterally at a dose of 3 mgkg via ICV to rats, and BV treatment at a dose of 2 gkg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF- and IL-1 levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.

 Alzheimers disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla BV has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anticholinesterase and anti- inflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular ICV administration of streptozotocin STZ. STZ was administered bilaterally at a dose of 3 mgkg via ICV to rats, and BV treatment at a dose of 2 gkg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF- and IL-1 levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.

 Alzheimers disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla BV has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anticholinesterase and anti- inflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular ICV administration of streptozotocin STZ. STZ was administered bilaterally at a dose of 3 mgkg via ICV to rats, and BV treatment at a dose of 2 gkg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF- and IL-1 levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.

Makale detayları

Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Yazarlar:

Büşra Ertaş | Rezzan Gülhan | Refiye Yanardağ | Özlem Saçan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.589-599

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346225

pISSN:

2630-6344

Alzheimer’s disease

Beta vulgaris L. var. cicla

cholinergic dysfunction

neuroinflammation

cognitive function

Sayı

Makale detayları

Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Yazarlar: Büşra Ertaş | Rezzan Gülhan | Refiye Yanardağ | Özlem Saçan | Göksel Şener

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.25 Issue 5, pp.589-599

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346225

pISSN: 2630-6344

Alzheimer’s disease

Beta vulgaris L. var. cicla

cholinergic dysfunction

neuroinflammation

cognitive function

Sayı

Yazarlar:

Büşra Ertaş | Rezzan Gülhan | Refiye Yanardağ | Özlem Saçan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.589-599

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346225

pISSN:

2630-6344