Neutrophil-to-high-density lipoprotein ratio: an independent predictor of infarct-related artery patency in patients with acute myocardial infarction

Bekir Demirtaş; Zehra Güven Çetin

Makale detayları

Neutrophil-to-high-density lipoprotein ratio: an independent predictor of infarct-related artery patency in patients with acute myocardial infarction

Yazarlar:

Bekir Demirtaş | Zehra Güven Çetin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 5, pp.400-405

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302579

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: The definition of an infarct-related artery IRA is a coronary artery occluded by a thrombus or atheroma that causes ischemia during acute myocardial infarction AMI. Early patency of the IRA is the primary goal of treatment in patients with AMI. The neutrophil high-density lipoprotein cholesterol HDL-C ratio NHR has been recognized as a new inflammatory marker. We aimed to show the possible relationship between NHR and preprocedural IRA patency. Methods: Four hundred patients were screened, and 318 were included in the study after exclusion criteria. IRA flow rate before the coronary procedure was determined according to the previously described thrombolysis in myocardial infarction TIMI. TIMI current 0,1 and 2 patients were considered IRA non-patent, and TIMI-3 patients were considered IRA patent and were divided into two groups. Regression analysis was performed for possible parameters in predicting IRA patency, evaluated in univariable analysis, and those with p-value 0.05 were assessed in multivariable analysis. Results: The mean age was 62.3  11.9 years, and 73.4 were male. In multivariable logistic regression analysis, high peak troponin ngmL p0.001, Odds Ratio OR: 0.936, 95 Confidence Intervals CIs: 0.910 - 0.962 and NHR p 0.020, OR: 0.043, 95 CIs: 0.003 - 0.603 levels were found to be independent predictors of patent IRA. Conclusion: Our study investigated the relationship between IRA patency and NHR in AMI patients. The main finding of our research is that significantly higher NHR and peak troponin levels were associated with non-patent IRA patients and were independent predictors.

 Aims: The definition of an infarct-related artery IRA is a coronary artery occluded by a thrombus or atheroma that causes ischemia during acute myocardial infarction AMI. Early patency of the IRA is the primary goal of treatment in patients with AMI. The neutrophil high-density lipoprotein cholesterol HDL-C ratio NHR has been recognized as a new inflammatory marker. We aimed to show the possible relationship between NHR and preprocedural IRA patency. Methods: Four hundred patients were screened, and 318 were included in the study after exclusion criteria. IRA flow rate before the coronary procedure was determined according to the previously described thrombolysis in myocardial infarction TIMI. TIMI current 0,1 and 2 patients were considered IRA non-patent, and TIMI-3 patients were considered IRA patent and were divided into two groups. Regression analysis was performed for possible parameters in predicting IRA patency, evaluated in univariable analysis, and those with p-value 0.05 were assessed in multivariable analysis. Results: The mean age was 62.3  11.9 years, and 73.4 were male. In multivariable logistic regression analysis, high peak troponin ngmL p0.001, Odds Ratio OR: 0.936, 95 Confidence Intervals CIs: 0.910 - 0.962 and NHR p 0.020, OR: 0.043, 95 CIs: 0.003 - 0.603 levels were found to be independent predictors of patent IRA. Conclusion: Our study investigated the relationship between IRA patency and NHR in AMI patients. The main finding of our research is that significantly higher NHR and peak troponin levels were associated with non-patent IRA patients and were independent predictors.

 Aims: The definition of an infarct-related artery IRA is a coronary artery occluded by a thrombus or atheroma that causes ischemia during acute myocardial infarction AMI. Early patency of the IRA is the primary goal of treatment in patients with AMI. The neutrophil high-density lipoprotein cholesterol HDL-C ratio NHR has been recognized as a new inflammatory marker. We aimed to show the possible relationship between NHR and preprocedural IRA patency. Methods: Four hundred patients were screened, and 318 were included in the study after exclusion criteria. IRA flow rate before the coronary procedure was determined according to the previously described thrombolysis in myocardial infarction TIMI. TIMI current 0,1 and 2 patients were considered IRA non-patent, and TIMI-3 patients were considered IRA patent and were divided into two groups. Regression analysis was performed for possible parameters in predicting IRA patency, evaluated in univariable analysis, and those with p-value 0.05 were assessed in multivariable analysis. Results: The mean age was 62.3  11.9 years, and 73.4 were male. In multivariable logistic regression analysis, high peak troponin ngmL p0.001, Odds Ratio OR: 0.936, 95 Confidence Intervals CIs: 0.910 - 0.962 and NHR p 0.020, OR: 0.043, 95 CIs: 0.003 - 0.603 levels were found to be independent predictors of patent IRA. Conclusion: Our study investigated the relationship between IRA patency and NHR in AMI patients. The main finding of our research is that significantly higher NHR and peak troponin levels were associated with non-patent IRA patients and were independent predictors.

 Amaç: İnfarkt ilişkili arter İRA tanımı, akut miyokard infarktüsü AMI sırasında iskemiye neden olan bir trombüs veya aterom tarafından tıkanmış bir koroner arterdir. IRAnın erken açıklığı, AMIli hastalarında tedavinin birincil amacıdır. Nötrofilyüksek yoğunluklu lipoprotein kolesterol HDL-K oranı NHO yeni bir inflamatuar belirteç olarak kabul edilmiştir. NHO ile işlem öncesi İRA açıklığı arasındaki olası ilişkiyi göstermeyi amaçladık. Yöntem: 400 hasta tarandı ve 318 dışlama kriterlerinden sonra çalışmaya dahil edildi. Koroner prosedür öncesi İRA akış hızı, daha önce tarif edilen miyokard enfarktüsünde tromboliz sınıflamasına TIMI göre belirlendi. TIMI mevcut 0,1 ve 2 hastalar IRA non-patent, TIMI-3 hastalar IRA patent olarak kabul edildi ve iki gruba ayrıldı. IRA açıklığını tahmin etmede olası parametreler için regresyon analizi yapıldı, tek değişkenli analizde değerlendirildi ve p değeri 0,05 olanlar çok değişkenli analizde değerlendirildi. Bulgular: Ortalama yaş 62,3  11,9 ve 73,4ü erkekti. Çok değişkenli lojistik regresyon analizinde, yüksek pik troponin ngmL p0,001, Odds Ratio OR: 0,936, 95 Güven Aralıkları GA: 0,910 - 0,962 ve NHO p 0,020, OR: 0,043, 95 GA: 0.003 - 0.603 seviyeleri, patent IRAnın bağımsız belirleyicileri olarak bulunmuştur. Sonuç: Çalışmamız, AMİ hastalarında İRA açıklığı ile NHO arasındaki ilişkiyi araştırdık. Araştırmamızın ana bulgusu, yüksek NHR ve pik troponin düzeylerinin, patent olmayan IRA hastalarıyla ilişkili olduğu ve bağımsız belirleyicileri olduğudur.

Makale detayları

Neutrophil-to-high-density lipoprotein ratio: an independent predictor of infarct-related artery patency in patients with acute myocardial infarction

Yazarlar:

Bekir Demirtaş | Zehra Güven Çetin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 5, pp.400-405

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302579

pISSN:

2717-7505

acute myocardial infarction

vascular patency

high-density lipoprotein

neutrophilakut miyokart enfarktüsü

vasküler açıklık

yüksek dansiteli lipoprotein

nötrofil

Sayı

Makale detayları

Yazarlar: Bekir Demirtaş | Zehra Güven Çetin

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kardiyoloji

Dergi: Journal of Medicine and Palliative Care Vol.4 Issue 5, pp.400-405

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001302579

pISSN: 2717-7505

Sayı

Yazarlar:

Bekir Demirtaş | Zehra Güven Çetin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 5, pp.400-405

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302579

pISSN:

2717-7505