EVALUATION OF CARDIAC AUTONOMIC DYSFUNCTION AND THE RISK OF ARRHYTHMIA IN CHILDREN WITH MITRAL VALVE PROLAPSE

Abdullah Bindal; Murat Deveci

Makale detayları

EVALUATION OF CARDIAC AUTONOMIC DYSFUNCTION AND THE RISK OF ARRHYTHMIA IN CHILDREN WITH MITRAL VALVE PROLAPSE

Yazarlar:

Abdullah Bindal | Murat Deveci

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 2, pp.290-296

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292874

pISSN:

2717-8994

Anahtar kelimeler:

Özet:

 Objective: The occurrence of symptoms in patients with mitral valve prolapse MVP is linked to autonomic dysfunction and neuroendocrine causes rather than progressive mitral valve insufficiency. The goal was to assess the risk of autonomic dysfunction and arrhythmia in patients with MVP. Methods: The study included 63 patients with primary MVP and a control group of 64 children of similar age and gender. Following a physical examination, all patients histories were taken, and 12-lead ECGs, autonomic function tests, echocardiography, and 24-hour Holter rhythm studies were performed. Results: The patient group had a higher mean resting heart rate than the control group. Orthostatic hypotension was found in 8 patients 12.6 and 4 children 6.2 in the control group. When compared to the control group, patients with MVP had higher QTc dispersion, frontal QRS-T angle, Tp-e interval, and Tp-eQTc ratio. There was no significant difference between the two groups in terms of conventional measurements of heart rate variability in the Holter ECG, as well as no significant difference in HRDC. Conclusion: Although cases with pathological findings in the initial ECG were excluded from our study, we believe that the high frontal QRS-T angle observed in MVP patients is a novel and significant finding. Furthermore, it has been discovered that HRDC, a new and understudied parameter in children, does not show a significant difference in patients with MVP.

 Objective: The occurrence of symptoms in patients with mitral valve prolapse MVP is linked to autonomic dysfunction and neuroendocrine causes rather than progressive mitral valve insufficiency. The goal was to assess the risk of autonomic dysfunction and arrhythmia in patients with MVP. Methods: The study included 63 patients with primary MVP and a control group of 64 children of similar age and gender. Following a physical examination, all patients histories were taken, and 12-lead ECGs, autonomic function tests, echocardiography, and 24-hour Holter rhythm studies were performed. Results: The patient group had a higher mean resting heart rate than the control group. Orthostatic hypotension was found in 8 patients 12.6 and 4 children 6.2 in the control group. When compared to the control group, patients with MVP had higher QTc dispersion, frontal QRS-T angle, Tp-e interval, and Tp-eQTc ratio. There was no significant difference between the two groups in terms of conventional measurements of heart rate variability in the Holter ECG, as well as no significant difference in HRDC. Conclusion: Although cases with pathological findings in the initial ECG were excluded from our study, we believe that the high frontal QRS-T angle observed in MVP patients is a novel and significant finding. Furthermore, it has been discovered that HRDC, a new and understudied parameter in children, does not show a significant difference in patients with MVP.

 Objective: The occurrence of symptoms in patients with mitral valve prolapse MVP is linked to autonomic dysfunction and neuroendocrine causes rather than progressive mitral valve insufficiency. The goal was to assess the risk of autonomic dysfunction and arrhythmia in patients with MVP. Methods: The study included 63 patients with primary MVP and a control group of 64 children of similar age and gender. Following a physical examination, all patients histories were taken, and 12-lead ECGs, autonomic function tests, echocardiography, and 24-hour Holter rhythm studies were performed. Results: The patient group had a higher mean resting heart rate than the control group. Orthostatic hypotension was found in 8 patients 12.6 and 4 children 6.2 in the control group. When compared to the control group, patients with MVP had higher QTc dispersion, frontal QRS-T angle, Tp-e interval, and Tp-eQTc ratio. There was no significant difference between the two groups in terms of conventional measurements of heart rate variability in the Holter ECG, as well as no significant difference in HRDC. Conclusion: Although cases with pathological findings in the initial ECG were excluded from our study, we believe that the high frontal QRS-T angle observed in MVP patients is a novel and significant finding. Furthermore, it has been discovered that HRDC, a new and understudied parameter in children, does not show a significant difference in patients with MVP.

 Amaç: Mitral kapak prolapsusu MKP saptanan olgularda yakınmaların ortaya çıkışı ilerleyici mitral kapak yetersizliğinden çok otonomik işlev bozukluğu ve nöroendokrin nedenlere bağlıdır. Bu çalışmada MKP tanısı ile izlenen çocukların otonomik disfonksiyon ve aritmi riski açısından değerlendirilmesi amaçlanmıştır. Yöntem: Çalışmaya primer MKP tanılı 63 hasta ve benzer yaş ve cinsiyetteki 64 çocuktan oluşan kontrol grubu dahil edildi. Tüm hastaların öyküleri alındı, fizik muayeneleri yapıldıktan sonra; 12 derivasyonlu EKGleri, otonom işlev testleri, ekokardiyografi 24-saatlik ritim Holter incelemeleri gerçekleştirildi. Bulgular: Ortalama dinlenme kalp hızı, hasta grubunda kontrol grubuna göre daha yüksek bulundu. Ortostatik hipotansiyon hasta grubunda 8 çocukta 12,6, kontrol grubunda ise 4 çocukta 6,2 saptandı. Yüzeyel EKGde QTc dispersiyonu, frontal QRS-T açısı, Tp-e aralığı ve Tp-eQTc oranı MKPli hastalarda kontrol grubuna göre yüksek saptandı. Holter EKGde kalp hızı değişkenliğini gösteren konvansiyonel ölçümler açısından iki grup arasında anlamlı fark saptanmadığı gibi HRDC açısından da iki grup arasında anlamlı fark saptanmadı. Sonuç: Çalışmamıza başlangıç EKGsinde patolojik bulgusu olan olgular dâhil edilmemesine rağmen MKPli hastalarda yüksek frontal QRS-T açısının tespit edilmiş olmasının yeni ve önemli bir bulgu olduğunu düşünmekteyiz. Ayrıca yeni ve çocuklarda az çalışılmış bir parametre olan HRDCnin MKP li hastalarda anlamlı farklılık göstermediği ortaya çıkmış olup bununla ilgili daha fazla çalışmaya ihtiyaç vardır.

Makale detayları

EVALUATION OF CARDIAC AUTONOMIC DYSFUNCTION AND THE RISK OF ARRHYTHMIA IN CHILDREN WITH MITRAL VALVE PROLAPSE

Yazarlar:

Abdullah Bindal | Murat Deveci

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 2, pp.290-296

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292874

pISSN:

2717-8994

Mitral valve prolapse

autonomic dysfunction

arrhythmiaMitral kapak prolapsusu

otonom disfonksiyon

aritmi

çocuk

Sayı

Makale detayları

EVALUATION OF CARDIAC AUTONOMIC DYSFUNCTION AND THE RISK OF ARRHYTHMIA IN CHILDREN WITH MITRAL VALVE PROLAPSE

Yazarlar: Abdullah Bindal | Murat Deveci

Yayıncı: Kocaeli University

Ana Başlıklar: Çocuk Sağlığı ve Hastalıkları

Dergi: Acta Medica Nicomedia Vol.6 Issue 2, pp.290-296

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292874

pISSN: 2717-8994

Mitral valve prolapse

autonomic dysfunction

arrhythmiaMitral kapak prolapsusu

otonom disfonksiyon

aritmi

çocuk

Sayı

Yazarlar:

Abdullah Bindal | Murat Deveci

Yayıncı:

Kocaeli University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Acta Medica Nicomedia Vol.6 Issue 2, pp.290-296

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292874

pISSN:

2717-8994