The effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight

Ahmet GÜZEL; Serap KARASALİHOĞLU

Makale detayları

The effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight

Yazarlar:

Ahmet GÜZEL | Serap KARASALİHOĞLU

Yayıncı:

Duzce University

Ana Başlıklar:

Hastalıklar

Dergi:

Duzce Medical Journal 2009 Vol.11 Issue 1, pp.13-20

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000944800

Sıklık:

Üç Yıllık

eISSN:

1307-671X

Anahtar kelimeler:

Özet:

 

Objectives: This study aims to evaluate the effects of valproate (VPA) and carbamazepine (CBZ) intake on serum leptin, insulin, lipid profiles, C-reactive protein (CRP) levels, C-peptid and weight. Patients and methods: Twenty-nine using VPA (Group I), and 21 patients using CBZ (Group II) aged 1.5-15 years and 35 healthy children (Group III) were included. Results: The rates of weight intake according to body mass index percentile increaase were 6.9 %, (2 cases) in the Group I and 19 % (4 cases) in the Group II. In Group II, levels of only LDL-K and TK were significantly higher than in Group I, but increasing of these lipids were not statistically significant compared with the control group. However, no significant effect of serum levels of leptin, insulin, lipid profile, CRP, and C-peptide were observed on weight intake. Conclusion: The etiology of weight gain due to VPA and CBZ intake was not associated with hyperleptinemia, hyperinsulinemia and hyperlipidemia. Multifactorial associations among heredity, socioeconomic factors, dietary habits, enviromental factors and family education should be taken into consideration in the etiology of weight gain secondary to antiepileptics. Further new studies about this subject should be performed.

 

Objectives: This study aims to evaluate the effects of valproate (VPA) and carbamazepine (CBZ) intake onserum leptin, insulin, lipid profiles, C-reactive protein (CRP) levels, C-peptid and weight.Patients and methods: Twenty-nine using VPA (Group I), and 21 patients using CBZ (Group II) aged 1.5-15years and 35 healthy children (Group III) were included.Results: The rates of weight intake according to body mass index percentile increaase were 6.9 %, (2 cases) inthe Group I and 19 % (4 cases) in the Group II. In Group II, levels of only LDL-K and TK were significantlyhigher than in Group I, but increasing of these lipids were not statistically significant compared with the controlgroup. However, no significant effect of serum levels of leptin, insulin, lipid profile, CRP, and C-peptide wereobserved on weight intake.Conclusion: The etiology of weight gain due to VPA and CBZ intake was not associated with hyperleptinemia,hyperinsulinemia and hyperlipidemia. Multifactorial associations among heredity, socioeconomic factors,dietary habits, enviromental factors and family education should be taken into consideration in the etiology ofweight gain secondary to antiepileptics. Further new studies about this subject should be performed.

Makale detayları

The effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight

Yazarlar:

Ahmet GÜZEL | Serap KARASALİHOĞLU

Yayıncı:

Duzce University

Ana Başlıklar:

Hastalıklar

Dergi:

Duzce Medical Journal 2009 Vol.11 Issue 1, pp.13-20

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000944800

Sıklık:

Üç Yıllık

eISSN:

1307-671X

Valproic acid

carbamazepine

obesity

leptin

insulin

Sayı

Makale detayları

The effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight

Yazarlar: Ahmet GÜZEL | Serap KARASALİHOĞLU

Yayıncı: Duzce University

Ana Başlıklar: Hastalıklar

Dergi: Duzce Medical Journal 2009 Vol.11 Issue 1, pp.13-20

Belge Tipi: Makale

Yayın Tarihi: 2/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000944800

Sıklık: Üç Yıllık

eISSN: 1307-671X

Valproic acid

carbamazepine

obesity

leptin

insulin

Sayı

Yazarlar:

Ahmet GÜZEL | Serap KARASALİHOĞLU

Yayıncı:

Duzce University

Ana Başlıklar:

Hastalıklar

Dergi:

Duzce Medical Journal 2009 Vol.11 Issue 1, pp.13-20

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000944800

Sıklık:

Üç Yıllık

eISSN:

1307-671X