A letter in response to "Cancer stem cells: emerging actors in both basic and clinical cancer research" Turk J Biol (2014) 38: ©TÜBITAK - doi:10.3906/biy-1406-93 Cancer stem cells (CSCs): targets and strategies for intervention

SURESH PALAMADAI KRISHNAN

Makale detayları

A letter in response to "Cancer stem cells: emerging actors in both basic and clinical cancer research" Turk J Biol (2014) 38: ©TÜBITAK - doi:10.3906/biy-1406-93 Cancer stem cells (CSCs): targets and strategies for intervention

Yazarlar:

SURESH PALAMADAI KRISHNAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2015 Vol.39 Issue 3, pp.517-521

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000811951

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

This letter to the editor highlights the important aspects of cancer stem cells and provides a deeper insight into the origin and characterization of these cells as well as the mechanisms contributing to drug resistance and relapse. The two currently available models (CSC and the clonal evolution model) need not be mutually exclusive to explain the origin of CSCs. The identification of CSCs (based on surface markers, drug efflux, enzyme activity, and signal transduction molecules and proteins involved in EMT processes) can help in discriminating these cells from other cell types. Moreover, CSCs prefer a hypoxic environment. This microenvironmental cue can trigger certain metabolic alterations that can orchestrate a rewiring of the epigenome. Consequently, changes in transcription factors and signaling molecules can contribute to the plasticity/inter-convertibility of the CSCs and non-CSC cellular states. Hence, an improved understanding of the mechanisms involved also provides opportunities for pharmacological manipulations. This letter also underscores the presence of precancerous stem cells as well as very small embryonic-like stem cells (VSELs) (both considered to be precursors of CSCs). These reports warrant a thorough reanalysis of the source of CSCs (lineage tracing studies), subsequent to the development of better targeted intervention approaches.

 

This letter to the editor highlights the important aspects of cancer stem cells and provides a deeper insight into the origin and characterization of these cells as well as the mechanisms contributing to drug resistance and relapse. The two currently available models (CSC and the clonal evolution model) need not be mutually exclusive to explain the origin of CSCs. The identification of CSCs (based on surface markers, drug efflux, enzyme activity, and signal transduction molecules and proteins involved in EMT processes) can help in discriminating these cells from other cell types. Moreover, CSCs prefer a hypoxic environment. This microenvironmental cue can trigger certain metabolic alterations that can orchestrate a rewiring of the epigenome. Consequently, changes in transcription factors and signaling molecules can contribute to the plasticity/inter-convertibility of the CSCs and non-CSC cellular states. Hence, an improved understanding of the mechanisms involved also provides opportunities for pharmacological manipulations. This letter also underscores the presence of precancerous stem cells as well as very small embryonic-like stem cells (VSELs) (both considered to be precursors of CSCs). These reports warrant a thorough reanalysis of the source of CSCs (lineage tracing studies), subsequent to the development of better targeted intervention approaches.

Makale detayları

A letter in response to "Cancer stem cells: emerging actors in both basic and clinical cancer research" Turk J Biol (2014) 38: ©TÜBITAK - doi:10.3906/biy-1406-93 Cancer stem cells (CSCs): targets and strategies for intervention

Yazarlar:

SURESH PALAMADAI KRISHNAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2015 Vol.39 Issue 3, pp.517-521

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000811951

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Cancer stem cells

precancerous stem cells

very small embryonic-like stem cells

pharmacological strategies

drug resistance

Sayı

Makale detayları

A letter in response to "Cancer stem cells: emerging actors in both basic and clinical cancer research" Turk J Biol (2014) 38: ©TÜBITAK - doi:10.3906/biy-1406-93 Cancer stem cells (CSCs): targets and strategies for intervention

Yazarlar: SURESH PALAMADAI KRISHNAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2015 Vol.39 Issue 3, pp.517-521

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000811951

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Cancer stem cells

precancerous stem cells

very small embryonic-like stem cells

pharmacological strategies

drug resistance

Sayı

Yazarlar:

SURESH PALAMADAI KRISHNAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2015 Vol.39 Issue 3, pp.517-521

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000811951

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152