May Nesfatin-1 is a New Marker of Inflammation in Varicose Veins?

Mehmet Kirişci; Sezen Koçarslan

Makale detayları

May Nesfatin-1 is a New Marker of Inflammation in Varicose Veins?

Yazarlar:

Mehmet Kirişci | Sezen Koçarslan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.58-64

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343477

pISSN:

1303-6610

Anahtar kelimeler:

Özet:

 Objective: The expression of nesfatin-1, an anti-inflammatory peptide, in varicose saphenous veins, may indicate the inflammation process in these veins. For this purpose, we aimed to determine the presence nesfatin-1 in varicose veins. Materials and methods: In this study, varicose vein samples have been taken from 50 patients with varicose veins. For the control group, vena saphena magna tissue samples taken out for coronary bypass were obtained from 50 patients. Immunohistochemical staining was performed by staining tissues with nesfatin-1 antibody and two groups were compared. Results: In the immunostaining of nesfatin-1 on varicose vein samples, 38 76 patients were determined to be positive, and no staining was observed in 12 24 patients. In saphenous tissue samples taken from the control group, 10 samples 20 were stained positive with nesfatin immunostaining, while 40 samples 80 were not stained. Staining of varicose veins with nesfatin immunostaining showed a statistically significant difference compared to the staining of samples taken from the control group p0.0001. Conclusion: When compared to healthy veins, it was demonstrated that the varicose etiopathogenesis. It is concluded that the expression of nesfatin-1, which is an anti-inflammatory peptide, in varicose veins may be a response to the inflammatory process.

 Objective: The expression of nesfatin-1, an anti-inflammatory peptide, in varicose saphenous veins, may indicate the inflammation process in these veins. For this purpose, we aimed to determine the presence nesfatin-1 in varicose veins. Materials and methods: In this study, varicose vein samples have been taken from 50 patients with varicose veins. For the control group, vena saphena magna tissue samples taken out for coronary bypass were obtained from 50 patients. Immunohistochemical staining was performed by staining tissues with nesfatin-1 antibody and two groups were compared. Results: In the immunostaining of nesfatin-1 on varicose vein samples, 38 76 patients were determined to be positive, and no staining was observed in 12 24 patients. In saphenous tissue samples taken from the control group, 10 samples 20 were stained positive with nesfatin immunostaining, while 40 samples 80 were not stained. Staining of varicose veins with nesfatin immunostaining showed a statistically significant difference compared to the staining of samples taken from the control group p0.0001. Conclusion: When compared to healthy veins, it was demonstrated that the varicose etiopathogenesis. It is concluded that the expression of nesfatin-1, which is an anti-inflammatory peptide, in varicose veins may be a response to the inflammatory process.

 Objective: The expression of nesfatin-1, an anti-inflammatory peptide, in varicose saphenous veins, may indicate the inflammation process in these veins. For this purpose, we aimed to determine the presence nesfatin-1 in varicose veins. Materials and methods: In this study, varicose vein samples have been taken from 50 patients with varicose veins. For the control group, vena saphena magna tissue samples taken out for coronary bypass were obtained from 50 patients. Immunohistochemical staining was performed by staining tissues with nesfatin-1 antibody and two groups were compared. Results: In the immunostaining of nesfatin-1 on varicose vein samples, 38 76 patients were determined to be positive, and no staining was observed in 12 24 patients. In saphenous tissue samples taken from the control group, 10 samples 20 were stained positive with nesfatin immunostaining, while 40 samples 80 were not stained. Staining of varicose veins with nesfatin immunostaining showed a statistically significant difference compared to the staining of samples taken from the control group p0.0001. Conclusion: When compared to healthy veins, it was demonstrated that the varicose etiopathogenesis. It is concluded that the expression of nesfatin-1, which is an anti-inflammatory peptide, in varicose veins may be a response to the inflammatory process.

 Amaç: Varisli safen venlerinde bir anti-inflamatuar peptid olan nesfatin-1in ekspresyonu, bu damarlarındaki inflamasyon sürecinin bir göstergesi olabilir. Bu amaçla, varisli venlerde nesfatin-1in varlığını belirlemeyi hedefledik. Gereç ve yöntemler: Bu çalışmada, varisli ven örnekleri 50 varis hastasından alındı. Kontrol grubu için, koroner bypass amacıyla alınan vena safena magna doku örnekleri 50 hastadan elde edildi. Nesfatin-1 antikoru ile immünohistokimyasal boyama yapıldı ve iki grup karşılaştırıldı. Bulgular: Varisli ven örneklerinde nesfatin-1 immünohistokimyası yapıldığında, 38 76 hastada pozitif boyama saptandı, 12 24 hastada ise boyama gözlemlenmedi. Kontrol grubundan alınan safen ven dokusu örneklerinde ise 10 örnek 20 nesfatin ile pozitif boyandı, 40 örnek 80 ise boyanmadı. Varisli venlerde nesfatin immünohistokimyası ile yapılan boyama, kontrol grubundaki örneklerin boyama sonuçları ile istatistiksel olarak anlamlı bir fark gösterdi p0,0001. Sonuç: Sağlıklı venlerle karşılaştırıldığında, varisli venlerin nesfatin-1 ile güçlü bir şekilde boyandığı gösterilmiştir. Nesfatin-1in varisli venlerdeki ekspresyonu, inflamasyon sürecine bir yanıt olabilir ve varisli venlerin etiyopatogenezi açısından önemli bir rol oynayabilir. Nesfatin-1in bir anti-inflamatuar peptid olarak varisli venlerdeki ifadesi, inflamasyon sürecine bir yanıt olabilir.

Makale detayları

May Nesfatin-1 is a New Marker of Inflammation in Varicose Veins?

Yazarlar:

Mehmet Kirişci | Sezen Koçarslan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.58-64

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343477

pISSN:

1303-6610

Nesfatin 1

Varicose vein

Inflammation

Coronary bypassNesfatin 1

Varisli ven

İnflamasyon

Koroner bypass

Sayı

Makale detayları

Yazarlar: Mehmet Kirişci | Sezen Koçarslan

Yayıncı: Kahramanmaras Sutcu Imam University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.58-64

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343477

pISSN: 1303-6610

Sayı

Yazarlar:

Mehmet Kirişci | Sezen Koçarslan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 1, pp.58-64

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343477

pISSN:

1303-6610