Global trends and scientific networks in mesenchymal stem cell research in hematology: a 20-year bibliometric insight

Neslihan Mandacı Şanlı; Edanur Dilara Mandacı

Makale detayları

Global trends and scientific networks in mesenchymal stem cell research in hematology: a 20-year bibliometric insight

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.290-297

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357452

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: Mesenchymal stem cells MSCs are multipotent stromal cells that are differentiated due to their differentiation potential and immunomodulatory activities, which is highly relevant to regenerative medicine and hematological therapies. MSCs remain one of the most actively pursued research areas in bioengineering, however, their bibliometric structure in the context of hematology is MSCs has not been thoroughly investigated. In this particular case, we set out to assess MSCs in the field of hematology by evaluating scientific output, its thematic evolution, as well as patterns of global collaboration using bibliometric techniques. Methods: With the keyword MSCs in the title and restricted to the hematology category, a total of 1.656 publications from the years 2005 to 2024 were retrieved using Web of Science Core Collection. The data was analyzed using VOSviewer v1.6.11 and SPSS v25.0. Trends in annual publication activities, journal output per publication, citation rates of the most cited works, co authored keyword networks, institutional and author cooperation networks, and and citation activity by country was examined. Results: As noted, there was a significant increase in the publication rate from 2011-2015, followed by a decrease after this period. Over 65 of publications were contributed by two journalsStem Cells and Development and Stem Cells. Studies that received the most citations concentrated on the immunomodulatory mechanisms of MSCs and the specific properties of tissues. University of Genoa claimed the highest citation count per article, whereas Chinese higher education institutions published the most on the topic. Core themes such as differentiation, bone marrow, transplantation, and exosomes emerged from the analysis on keyword clustering. The most noteworthy research backbone on the topic was developed collaboratively between the US and China, who both possessed strong global network intercontinental links. Conclusion: Research on MSCs in the context of hematology showcases mature thematic development, intensive institutional collaboration, and regional collaboration clustering. The area of MSCs in hematology indicates foundational research exhaustion, but an expanding focus on exosomes and therapies that do not involve cells signals prospective, shift aimed at clinical. The work can strategically direct funding, policy, and interdisciplinary collaboration MSCs in policymaking guidance MSCs in hematology applications mean interdisciplinary MSCs guide policy.

 Aims: Mesenchymal stem cells MSCs are multipotent stromal cells that are differentiated due to their differentiation potential and immunomodulatory activities, which is highly relevant to regenerative medicine and hematological therapies. MSCs remain one of the most actively pursued research areas in bioengineering, however, their bibliometric structure in the context of hematology is MSCs has not been thoroughly investigated. In this particular case, we set out to assess MSCs in the field of hematology by evaluating scientific output, its thematic evolution, as well as patterns of global collaboration using bibliometric techniques. Methods: With the keyword MSCs in the title and restricted to the hematology category, a total of 1.656 publications from the years 2005 to 2024 were retrieved using Web of Science Core Collection. The data was analyzed using VOSviewer v1.6.11 and SPSS v25.0. Trends in annual publication activities, journal output per publication, citation rates of the most cited works, co authored keyword networks, institutional and author cooperation networks, and and citation activity by country was examined. Results: As noted, there was a significant increase in the publication rate from 2011-2015, followed by a decrease after this period. Over 65 of publications were contributed by two journalsStem Cells and Development and Stem Cells. Studies that received the most citations concentrated on the immunomodulatory mechanisms of MSCs and the specific properties of tissues. University of Genoa claimed the highest citation count per article, whereas Chinese higher education institutions published the most on the topic. Core themes such as differentiation, bone marrow, transplantation, and exosomes emerged from the analysis on keyword clustering. The most noteworthy research backbone on the topic was developed collaboratively between the US and China, who both possessed strong global network intercontinental links. Conclusion: Research on MSCs in the context of hematology showcases mature thematic development, intensive institutional collaboration, and regional collaboration clustering. The area of MSCs in hematology indicates foundational research exhaustion, but an expanding focus on exosomes and therapies that do not involve cells signals prospective, shift aimed at clinical. The work can strategically direct funding, policy, and interdisciplinary collaboration MSCs in policymaking guidance MSCs in hematology applications mean interdisciplinary MSCs guide policy.

 Aims: Mesenchymal stem cells MSCs are multipotent stromal cells that are differentiated due to their differentiation potential and immunomodulatory activities, which is highly relevant to regenerative medicine and hematological therapies. MSCs remain one of the most actively pursued research areas in bioengineering, however, their bibliometric structure in the context of hematology is MSCs has not been thoroughly investigated. In this particular case, we set out to assess MSCs in the field of hematology by evaluating scientific output, its thematic evolution, as well as patterns of global collaboration using bibliometric techniques. Methods: With the keyword MSCs in the title and restricted to the hematology category, a total of 1.656 publications from the years 2005 to 2024 were retrieved using Web of Science Core Collection. The data was analyzed using VOSviewer v1.6.11 and SPSS v25.0. Trends in annual publication activities, journal output per publication, citation rates of the most cited works, co authored keyword networks, institutional and author cooperation networks, and and citation activity by country was examined. Results: As noted, there was a significant increase in the publication rate from 2011-2015, followed by a decrease after this period. Over 65 of publications were contributed by two journalsStem Cells and Development and Stem Cells. Studies that received the most citations concentrated on the immunomodulatory mechanisms of MSCs and the specific properties of tissues. University of Genoa claimed the highest citation count per article, whereas Chinese higher education institutions published the most on the topic. Core themes such as differentiation, bone marrow, transplantation, and exosomes emerged from the analysis on keyword clustering. The most noteworthy research backbone on the topic was developed collaboratively between the US and China, who both possessed strong global network intercontinental links. Conclusion: Research on MSCs in the context of hematology showcases mature thematic development, intensive institutional collaboration, and regional collaboration clustering. The area of MSCs in hematology indicates foundational research exhaustion, but an expanding focus on exosomes and therapies that do not involve cells signals prospective, shift aimed at clinical. The work can strategically direct funding, policy, and interdisciplinary collaboration MSCs in policymaking guidance MSCs in hematology applications mean interdisciplinary MSCs guide policy.

 Amaç: Mezenkimal kök hücreler MSCler, farklılaşma potansiyelleri ve immünmodülatör aktiviteleri sayesinde rejeneratif tıp ve hematolojik tedavilerle yakından ilişkili olan multipotent stromal hücrelerdir. MSCler, biyomühendislik alanında en yoğun çalışılan konulardan biri olmaya devam etmektedir. Ancak hematoloji bağlamındaki bibliyometrik yapıları yeterince incelenmemiştir. Bu çalışmada, hematoloji alanındaki MSC araştırmaları; bilimsel çıktı hacmi, tematik evrimi ve küresel iş birliği ağları bağlamında bibliyometrik yöntemlerle değerlendirilmiştir. Yöntem: Mesenchymal stem cells anahtar kelimesi başlık alanında aranmış ve konu kategorisi olarak sadece Hematology sınırlaması getirilmiştir. Web of Science Core Collection veri tabanından 20052024 yılları arasındaki toplam 1.656 yayın elde edilmiştir. Veriler VOSviewer v1.6.11 ve SPSS v25.0 yazılımları ile analiz edilmiştir. Yıllara göre yayın eğilimleri, dergi bazında dağılımlar, en çok atıf alan yayınlar, anahtar kelime ağ yapıları, kurumsal ve yazarlara ait iş birliği ağları ve ülke bazlı atıf dağılımları değerlendirilmiştir. Bulgular: 20112015 döneminde belirgin bir yayın artışı gözlenmiş, bu dönemi takiben azalma eğilimi yaşanmıştır. Tüm yayınların 65inden fazlası yalnızca iki dergiye Stem Cells and Development ile Stem Cells aittir. En çok atıf alan çalışmalar, MSClerin immünmodülatör mekanizmaları ve dokuya özgü özelliklerine odaklanmıştır. University of Genoa, makale başına en yüksek atıfı alırken, Çindeki yükseköğretim kurumları en fazla yayını gerçekleştirmiştir. Anahtar kelime kümelerinde differentiation, bone marrow, transplantation ve exosomes gibi çekirdek temalar öne çıkmıştır. ABD ve Çin arasındaki güçlü kıtalararası bağlantılar, bu konudaki en önemli bilimsel ağların temellerini oluşturmuştur. Sonuç: MSClerin hematoloji bağlamındaki araştırmaları, tematik olgunluk, yoğun kurumsal iş birlikleri ve bölgesel kümelenme örüntüleri sergilemektedir. Alan, temel biyolojik araştırmalarda doygunluğa ulaşmış görünse de, hücresiz tedavi yaklaşımları ve ekzomlara yönelik yönelimin artması, daha klinik odaklı yeni bir araştırma evresine işaret etmektedir. Bu çalışma, MSClerin hematolojik uygulamalarındaki politika oluşturma süreçlerinde kaynak yönlendirmesi, fon stratejileri ve disiplinlerarası iş birlikleri açısından stratejik rehberlik sunmaktadır.

Makale detayları

Global trends and scientific networks in mesenchymal stem cell research in hematology: a 20-year bibliometric insight

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.290-297

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357452

pISSN:

2717-7505

Mesenchymal stem cells

hematology

bibliometric analysis

scientific collaborationMezenkimal kök hücreler

hematoloji

bibliyometrik analiz

bilimsel iş birliği

bilimsel ağ haritalama

Sayı

Makale detayları

Yazarlar: Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Hematoloji

Dergi: Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.290-297

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357452

pISSN: 2717-7505

Sayı

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.290-297

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357452

pISSN:

2717-7505