Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Servet GÜREŞCİ; Özlem ÖZMEN; Metin UZMAN; Gülçin ŞİMŞEK; Ebru TATCI; Atila GÖKÇEK; Abdullah Özgür YENİOVA

Makale detayları

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Yazarlar:

Servet GÜREŞCİ | Özlem ÖZMEN | Metin UZMAN | Gülçin ŞİMŞEK | Ebru TATCI | Atila GÖKÇEK | Abdullah Özgür YENİOVA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1182-1187

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751978

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.  Materials and methods: SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.    Results: Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.   Conclusion: The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient.

Makale detayları

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Yazarlar: Servet GÜREŞCİ | Özlem ÖZMEN | Metin UZMAN | Gülçin ŞİMŞEK | Ebru TATCI | Atila GÖKÇEK | Abdullah Özgür YENİOVA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1182-1187

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000751978

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Servet GÜREŞCİ | Özlem ÖZMEN | Metin UZMAN | Gülçin ŞİMŞEK | Ebru TATCI | Atila GÖKÇEK | Abdullah Özgür YENİOVA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1182-1187

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751978

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144