Investigation of Oxidative/Antioxidant Effects of Turmeric (Curcuma longa L.) Supplementation on Heart Tissue in Adult Rats

Şevkinaz Doğan; Aslıhan Cesur Turgut

Makale detayları

Investigation of Oxidative/Antioxidant Effects of Turmeric (Curcuma longa L.) Supplementation on Heart Tissue in Adult Rats

Yazarlar:

Şevkinaz Doğan | Aslıhan Cesur Turgut

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Health Care Administration

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.11 Issue 1, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289574

pISSN:

2148-2837

Anahtar kelimeler:

Özet:

 n present study, the effects of curcumin supplementation on oxidative stress and antioxidant defense system in heart tissue in adult rats were investigated. Sixteen rats 8-weeks-old were selected and divided into two groups. The first group is the experimental group and these rats n8 were gavaged with curcumin, dissolved in corn oil, at a dose of 300 mgkg per day for 28 days. The second group is the control group, rats in this group were given curcumin and equal amount of corn oil to eliminate the porter effect. Euthanasia was performed and total antioxidant capacity TAS, total oxidant capacity TOS, malondialdehyde MDA and glutathione GSH levels were analyzed from heart tissues. Curcumin supplementation resulted in significantly increased GSH levelsP0,05. However, curcumin supplementation decreased MDA levels although it was not statistically significant P0.05. The total antioxidant capacity TAS and total oxidant capacity TOS ratios were found to be statistically significant. In the other group supplemented with curcumin, MDA levels tended to decrease compared to the control group, and there was no statistically significant difference between the two groups. Curcumin supplementation protects the heart tissue against oxidative damage and strengthens the antioxidant defense system in adult rats.

 n present study, the effects of curcumin supplementation on oxidative stress and antioxidant defense system in heart tissue in adult rats were investigated. Sixteen rats 8-weeks-old were selected and divided into two groups. The first group is the experimental group and these rats n8 were gavaged with curcumin, dissolved in corn oil, at a dose of 300 mgkg per day for 28 days. The second group is the control group, rats in this group were given curcumin and equal amount of corn oil to eliminate the porter effect. Euthanasia was performed and total antioxidant capacity TAS, total oxidant capacity TOS, malondialdehyde MDA and glutathione GSH levels were analyzed from heart tissues. Curcumin supplementation resulted in significantly increased GSH levelsP0,05. However, curcumin supplementation decreased MDA levels although it was not statistically significant P0.05. The total antioxidant capacity TAS and total oxidant capacity TOS ratios were found to be statistically significant. In the other group supplemented with curcumin, MDA levels tended to decrease compared to the control group, and there was no statistically significant difference between the two groups. Curcumin supplementation protects the heart tissue against oxidative damage and strengthens the antioxidant defense system in adult rats.

 n present study, the effects of curcumin supplementation on oxidative stress and antioxidant defense system in heart tissue in adult rats were investigated. Sixteen rats 8-weeks-old were selected and divided into two groups. The first group is the experimental group and these rats n8 were gavaged with curcumin, dissolved in corn oil, at a dose of 300 mgkg per day for 28 days. The second group is the control group, rats in this group were given curcumin and equal amount of corn oil to eliminate the porter effect. Euthanasia was performed and total antioxidant capacity TAS, total oxidant capacity TOS, malondialdehyde MDA and glutathione GSH levels were analyzed from heart tissues. Curcumin supplementation resulted in significantly increased GSH levelsP0,05. However, curcumin supplementation decreased MDA levels although it was not statistically significant P0.05. The total antioxidant capacity TAS and total oxidant capacity TOS ratios were found to be statistically significant. In the other group supplemented with curcumin, MDA levels tended to decrease compared to the control group, and there was no statistically significant difference between the two groups. Curcumin supplementation protects the heart tissue against oxidative damage and strengthens the antioxidant defense system in adult rats.

 Bu çalışmada, erişkin ratlarda zerdaçal kurkumin takviyesinin kalp dokusundaki oksidatif stres ve antioksidan savunma sistemi üzerinde meydana getirdiği etkileri incelendi. Çalışmada 8 haftalık 16 adet rat kullanılmış ve bu ratlar iki gruba ayrılmıştır. İlk grup olan deney grubundaki ratlara n8 28 gün süresince günde 300 mgkg dozunda kurkumin C1386; Sigma Chemical, St. Louis, MO mısır yağı içinde çözdürülerek ağızdan gavaj yöntemi ile verildi. İkinci grup olan kontrol grubundaki ratlara ise portör etkisini yok etmek için kurkumin ile eşit miktarda mısır yağı verildi. Ötenazi gerçekleştirildikten sonra kalp dokuları alınarak total antioksidan kapasiteleri TAS, total oksidan kapasiteleri TOS, malondialdehit MDA ve glutatyon GSH seviyeleri analiz edildi. Kurkumin takviyesi GSH seviyelerini önemli ölçüde artırmıştır P0,05. Bununla birlikte, kurkumin takviyesi istatistiksel olarak anlamlı olamamasına rağmen MDA seviyelerini azaltmıştır P0,05. Total antioksidan kapasitesi TAS ve total oksidan kapasitesi TOS oranları istatistiksel olarak anlamlı bulundu. Kurkumin takviyeli diğer grupta MDA seviyeleri kontrol grubuna oranla azalma eğilimi göstermiş olup iki grup arasında anlamlı istatistiksel bir fark bulunmamıştır. Kurkumin takviyesi erişkin ratlarda kalp dokusunu oksidatif hasara karşı korumakta ve antioksidan savunma sistemini güçlendirmektedir.

Makale detayları

Investigation of Oxidative/Antioxidant Effects of Turmeric (Curcuma longa L.) Supplementation on Heart Tissue in Adult Rats

Yazarlar:

Şevkinaz Doğan | Aslıhan Cesur Turgut

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Health Care Administration

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.11 Issue 1, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289574

pISSN:

2148-2837

Curcumin

antioxidant

oxidative stress

heartKurkumin

antioksidan

oksidatif stres

kalp

Sayı

Makale detayları

Yazarlar: Şevkinaz Doğan | Aslıhan Cesur Turgut

Yayıncı: Burdur Mehmet Akif Ersoy University

Ana Başlıklar: Health Care Administration

Dergi: Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.11 Issue 1, pp.183-188

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289574

pISSN: 2148-2837

Sayı

Yazarlar:

Şevkinaz Doğan | Aslıhan Cesur Turgut

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Health Care Administration

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.11 Issue 1, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289574

pISSN:

2148-2837