Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Dilek Özbeyli; Büşra Ertaş; Ali Şen; Göksel Şener

Makale detayları

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Yazarlar:

Dilek Özbeyli | Büşra Ertaş | Ali Şen | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.865-873

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348010

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract MC has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet HFD, using behavioral and biochemical parameters. Twenty four Wistar albino rats 200250 g were divided into three groups. The control group C received a standard diet, while HFD groups were received HFD for 16 weeks. MC 100 mgkg, oral was given to the HFD  MC group for the last 4 weeks. At the end of the study, the novel object recognition test NORT was performed and the hippocampus and blood samples were collected. Acetylcholinesterase AChE and NaK ATPase activities, malondialdehyde MDA, 8-hydroxy-2-deoxyguanosine 8-OHdG and reduced glutathione GSH levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na K -ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

 Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract MC has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet HFD, using behavioral and biochemical parameters. Twenty four Wistar albino rats 200250 g were divided into three groups. The control group C received a standard diet, while HFD groups were received HFD for 16 weeks. MC 100 mgkg, oral was given to the HFD  MC group for the last 4 weeks. At the end of the study, the novel object recognition test NORT was performed and the hippocampus and blood samples were collected. Acetylcholinesterase AChE and NaK ATPase activities, malondialdehyde MDA, 8-hydroxy-2-deoxyguanosine 8-OHdG and reduced glutathione GSH levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na K -ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

 Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract MC has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet HFD, using behavioral and biochemical parameters. Twenty four Wistar albino rats 200250 g were divided into three groups. The control group C received a standard diet, while HFD groups were received HFD for 16 weeks. MC 100 mgkg, oral was given to the HFD  MC group for the last 4 weeks. At the end of the study, the novel object recognition test NORT was performed and the hippocampus and blood samples were collected. Acetylcholinesterase AChE and NaK ATPase activities, malondialdehyde MDA, 8-hydroxy-2-deoxyguanosine 8-OHdG and reduced glutathione GSH levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na K -ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

 Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract MC has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet HFD, using behavioral and biochemical parameters. Twenty four Wistar albino rats 200250 g were divided into three groups. The control group C received a standard diet, while HFD groups were received HFD for 16 weeks. MC 100 mgkg, oral was given to the HFD  MC group for the last 4 weeks. At the end of the study, the novel object recognition test NORT was performed and the hippocampus and blood samples were collected. Acetylcholinesterase AChE and NaK ATPase activities, malondialdehyde MDA, 8-hydroxy-2-deoxyguanosine 8-OHdG and reduced glutathione GSH levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na K -ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

Makale detayları

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Yazarlar:

Dilek Özbeyli | Büşra Ertaş | Ali Şen | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.865-873

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348010

pISSN:

2630-6344

Obesity

oxidative stress

Myrtus communis

acetylcholinesterase

Sayı

Makale detayları

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Yazarlar: Dilek Özbeyli | Büşra Ertaş | Ali Şen | Göksel Şener

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 6, pp.865-873

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348010

pISSN: 2630-6344

Obesity

oxidative stress

Myrtus communis

acetylcholinesterase

Sayı

Yazarlar:

Dilek Özbeyli | Büşra Ertaş | Ali Şen | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.865-873

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348010

pISSN:

2630-6344