Multicenter study of levodopa carbidopa intestinal gel in Parkinson's disease:  the Turkish experience

Murat GÜLTEKİN; Çağrı ULUKAN; Sabiha Tezcan AYDEMİR; Okan DOĞU; Haşmet Ayhan HANAĞASI; Başar BİLGİÇ; Ayşe Bora TOKÇAER; Raif ÇAKMUR; Bülent ELİBOL; Meral MİRZA; Dilek GÜNAL; Çiğdem Sevda Erer ÖZBEK; Gülay KENANGİL; Özge Yılmaz KÜSBECİ; Muhittin Cenk AKBOSTANCI

doi:https://doi.org/10.3906/sag-1904-150

Makale detayları

Multicenter study of levodopa carbidopa intestinal gel in Parkinson's disease: the Turkish experience

Yazarlar:

Murat GÜLTEKİN | Çağrı ULUKAN | Sabiha Tezcan AYDEMİR | Okan DOĞU | Haşmet Ayhan HANAĞASI | Başar BİLGİÇ | Ayşe Bora TOKÇAER | Raif ÇAKMUR | Bülent ELİBOL | Meral MİRZA | Dilek GÜNAL | Çiğdem Sevda Erer ÖZBEK | Gülay KENANGİL | Özge Yılmaz KÜSBECİ | Muhittin Cenk AKBOSTANCI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.66-85

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749661

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1904-150

Özet:

 

Background/aim: Our purpose was to determine the efficacy of levodopa carbidopa intestinal gel  LCIG  in a series of Turkish patients with Parkinson's disease  PD . Materials  and  methods:  We  had  telephone  calls  with  54  patients  from  11  neurology  centers  who  were  on  LCIG  treatment,  and  44  patients or their caregivers were included in an eight-item survey between September 2015 and June 2016. The reliability and validity of the survey were evaluated with intraclass correlation coefficients for every question separately.Results:  Average  age  of  the  patients  were  63.48  and  the  duration  of  PD  was  12.79  years.  Average  LCIG  treatment  period  was  15.63  months. Percentages of the patients who reported they were `better' after LCIG treatment were as follows: 80% for time spent off, 55% for dyskinesia, 65% for tremor, 85% for gait disorder, 50% for pain, 50% for sleep disorders, 42.5% for depression, 32.5% for incontinence, and 70% for activities of daily living. Cronbach's alpha was 0.795 and the intraclass correlation coefficient was reliable for the items.Conclusion: As detected by a survey performed by telephone calls with good interrater reliability, patients with PD improve with LCIG treatment in many aspects of the disease.

Makale detayları

Multicenter study of levodopa carbidopa intestinal gel in Parkinson's disease: the Turkish experience

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.66-85

Belge Tipi: Makale

Yayın Tarihi: 12/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749661

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1904-150

Sayı

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.66-85

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749661

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1904-150