Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

Ayşegül GÜMÜŞ; Veysi OKUMUŞ; Selçuk GÜMÜŞ

Makale detayları

Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

Yazarlar:

Ayşegül GÜMÜŞ | Veysi OKUMUŞ | Selçuk GÜMÜŞ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1358-1369

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000726007

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 


 
                         2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 
2-substituted-8-hydroxyquinolines by O-propargylation method (30%-98% 
yields). The newly synthesized compounds were tested for in vitro 
antioxidant activities such as DPPH radical scavenging, ferrous chelating, 
and reducing power activities. The maximum radical scavenging (46.5%) and 
reducing power activities were obtained from 1 and maximum ferrous 
chelating effect was obtained from 6 (72.1%) at the 
concentration of 500 μμg/mL. To indicate DNA binding activity of the 
complexes calf thymus DNA was used. The compounds were also evaluated for 
their antimicrobial activity against three gram-positive and three 
gram-negative bacteria. Compounds 3 and 5 exhibited 
antibacterial activity against all tested gram-positive bacteria.
                    

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Makale detayları

Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

Yazarlar: Ayşegül GÜMÜŞ | Veysi OKUMUŞ | Selçuk GÜMÜŞ

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1358-1369

Belge Tipi: Makale

Yayın Tarihi: 10/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000726007

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Ayşegül GÜMÜŞ | Veysi OKUMUŞ | Selçuk GÜMÜŞ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1358-1369

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000726007

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527