QSARs of Some 5- or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles against Candida albicans

Özlem Temiz ARPACI

Makale detayları

QSARs of Some 5- or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles against Candida albicans

Yazarlar:

Özlem Temiz ARPACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.493-498

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757129

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

QSAR analysis of some 5- or 6-methyl-2-substituted benzoxazoles/ benzimidazoles was studied for the antifungal activity against C. albicans using Hansch analysis. Prediction for the lead optimization in this QSAR analysis was described by the description of various hydrophobic, electronic, steric and structural parameters related to positions R1, R2, R5, R6, X, Y. The cross-validation method was also applied to the data set in order to prove the predictive power by using the BILIN statistical software. The resulting QSAR revealed that substitution at position Y with the CH2 group was significant for the improved antifungal activity. Moreover, hydrophobic properties of the substituents at position R2 are indicative for the antifungal activity against C. albicans.

 

QSAR analysis of some 5- or 6-methyl-2-substituted benzoxazoles/ benzimidazoles was studied for the antifungal activity against C. albicans using Hansch analysis. Prediction for the lead optimization in this QSAR analysis was described by the description of various hydrophobic, electronic, steric and structural parameters related to positions R1, R2, R5, R6, X, Y. The cross-validation method was also applied to the data set in order to prove the predictive power by using the BILIN statistical software. The resulting QSAR revealed that substitution at position Y with the CH2 group was significant for the improved antifungal activity. Moreover, hydrophobic properties of the substituents at position R2 are indicative for the antifungal activity against C. albicans.

Makale detayları

QSARs of Some 5- or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles against Candida albicans

Yazarlar:

Özlem Temiz ARPACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.493-498

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757129

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Benzoxazole

Benzimidazole

Antifungal activity

QSAR

Hansch analysis

Sayı

Makale detayları

QSARs of Some 5- or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles against Candida albicans

Yazarlar: Özlem Temiz ARPACI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.493-498

Belge Tipi: Makale

Yayın Tarihi: 5/2001

Belge Dili: Türkçe

Document ID (Org No.): 2000757129

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Benzoxazole

Benzimidazole

Antifungal activity

QSAR

Hansch analysis

Sayı

Yazarlar:

Özlem Temiz ARPACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.493-498

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757129

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144