miR-1267 Induces Tumorigenicity and Contributes to Risk of Clear Cell Renal Cell Carcinoma

Sercan ERGÜN; Kalbiye KONANÇ

doi:https://doi.org/10.19127/mbsjohs.569404

Makale detayları

miR-1267 Induces Tumorigenicity and Contributes to Risk of Clear Cell Renal Cell Carcinoma

Yazarlar:

Sercan ERGÜN | Kalbiye KONANÇ

Yayıncı:

Ordu University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Middle Black Sea Journal of Health Science 2019 Vol.5 Issue 2, pp.100-105

Belge Tipi:

Makale

Yayın Tarihi:

8/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000564311

Sıklık:

Üç Yıllık

eISSN:

2149-7796

DOI:

https://doi.org/10.19127/mbsjohs.569404

Özet:

 





Objective: Dysregulated microRNA signatures in different cancer
types are being uncovered continually implying their significance in cancer
pathogenesis. miR-1267 was not previously associated with RCC. In this
study, it is aimed to obtain the expression profile of miR-1267 in patients
with ccRCC and its correlation with patient parameters. 




Methods:
Kidney Cancer cDNA Array consisting of cDNA samples obtained from healthy
kidney tissues of 4 healthy individuals and tumoral kidney tissues of 5 Stage
I, 5 Stage II, 3 Stage III and 2 Stage IV ccRCC patients was used. Hsa-miR-1267
and SNORD48 (as housekeeping gene) expressions were analyzed. miR-1267
expression was statistically correlated with the clinical parameters of
patients. miRGator 3.0 database was used to compare miR-1267 expression
patterns of different urological cancer types. 




Results:
The expression of miR-1267 was significantly higher in male than female
(p=0.027). Also, there were statistically significant increase in miR-1267
expression in stage IV when compared to stage I (p0.05). 




Conclusion: miR-1267 could have
oncogenic function, have predictive value for RCC development and be predictive
about aggressiveness in ccRCC. 




.

Makale detayları

miR-1267 Induces Tumorigenicity and Contributes to Risk of Clear Cell Renal Cell Carcinoma

Yazarlar: Sercan ERGÜN | Kalbiye KONANÇ

Yayıncı: Ordu University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Middle Black Sea Journal of Health Science 2019 Vol.5 Issue 2, pp.100-105

Belge Tipi: Makale

Yayın Tarihi: 8/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000564311

Sıklık: Üç Yıllık

eISSN: 2149-7796

DOI: https://doi.org/10.19127/mbsjohs.569404

Sayı

Yazarlar:

Sercan ERGÜN | Kalbiye KONANÇ

Yayıncı:

Ordu University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Middle Black Sea Journal of Health Science 2019 Vol.5 Issue 2, pp.100-105

Belge Tipi:

Makale

Yayın Tarihi:

8/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000564311

Sıklık:

Üç Yıllık

eISSN:

2149-7796

DOI:

https://doi.org/10.19127/mbsjohs.569404